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New eye treatment effective in laboratory tests
Date:10/23/2013

author of the new study. "We have now shown that microRNAs can inhibit the actions of multiple pro-angiogenic compounds including, but not limited to, VEGF. Blocking these 'downstream' targets would stop the aberrant blood vessel sprouting while maintaining the health of the normal blood vessels in the eye."

In the new study, the team focused on microRNA-132, blocking it in the eye and preventing Ras activation using a tiny 22-base anti-microRNA. This work was the first to test its effect for neovascular eye diseases, showing that the new approach inhibited angiogenesis in three different models of neovascular eye disease.

The researchers believe this work is especially promising, as other anti-microRNA-based therapies for different diseases are already in clinical trials.


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Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

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