Navigation Links
New eye treatment effective in laboratory tests
Date:10/23/2013

LA JOLLA, CA October 23, 2013 A promising technique for treating human eye disease has proven effective in preclinical studies and may lead to new treatments to prevent blindness, according to experiments conducted at The Scripps Research Institute (TSRI) in La Jolla, California.

The studies involved controlling the actions of microRNAs, tiny pieces of RNA that were once considered to be "junk" but are now known to fine-tune gene activation and expression. The researchers showed that treating mice with short RNA strands that precisely target and inhibit microRNAs ("antimicroRNAs") can stop the aberrant growth of blood vessels ("neovascularization").

It is this abnormal proliferation of vessels that exacerbates vision loss in neovascular eye diseases like "wet" macular degeneration and diabetic retinopathy, two of the leading causes of blindness.

Described in the cover story of the November issue of the Journal of Clinical Investigation, the microRNA treatments blocked aberrant vessel growth without damaging existing vasculature or neurons in three separate models of neovascular eye diseasea proof-of-principle that suggests future treatment based on the same approach may be effective in humans.

"We believe that targeting and inhibiting the action of microRNAs involved could represent a novel and effective way to treat a broad range of neovascular eye diseases such as diabetic retinopathy, macular degeneration and macular telangiectasia," said TSRI Professor Martin Friedlander, MD, PhD, who was senior author of the study. "We are excited about this approach to halting abnormal blood vessel growth without inducing off-target side effects."

The work is the first published result of a five-year, $10.2 million grant awarded last year by the National Eye Institute of the National Institutes of Health. The grant aims to harness the potential of microRNAs to stop abnormal blood vessel sprouting in the back of the
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Breakthroughs in Chikungunya research from A*STAR spell new hope for better treatment and protection
2. Collaborative preclinical efficacy studies suggest a new target for drug addiction treatment
3. Genetic research develops tools for studying diseases, improving regenerative treatment
4. Step forward in research into new treatments for brain edema
5. Marshall University study may lead to new treatments for prostate cancer
6. New discoveries about brain-hand connection sought to improve therapies, treatments, prosthetics
7. Minimally invasive treatment for ruptured aneurysm: Safe, reduces mortality
8. Penn research points to new way of preserving fertility for boys undergoing cancer treatment
9. Researcher who identifed genetic cause and possible treatment for Marfan syndrome honored
10. New discovery may lead to effective prevention and treatment of graft-versus-host dsease
11. Antipsychotic drug may be helpful treatment for anorexia nervosa
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New eye treatment effective in laboratory tests
(Date:6/10/2015)... According to a new ... (Ultrasound, TOF, Structured Light, Stereo Vision), Type(Image, Position, ... by Geography - Trends & Forecast to 2014 ... expected to reach $3,319.71 Million by 2020, growing ... 2020. Browse 71 market data tables ...
(Date:6/9/2015)... June 09, 2015 Research and Markets ... the "Gesture Recognition & Touchless Sensing Market ... Automotive, & Others), Product (Biometric & Sanitary Equipment) ... report to their offering. The ... expected to reach $ 23.55 Billion by 2020 ...
(Date:6/8/2015)... , June 8, 2015  The ... today their selection of Troy Potter ... effective immediately. SIBA is a non-profit association that ... responsible policy, education and implementation of solutions that ... platforms. ...
Breaking Biology News(10 mins):3D Sensor Market Worth $3,319.71 Million by 2020 23D Sensor Market Worth $3,319.71 Million by 2020 33D Sensor Market Worth $3,319.71 Million by 2020 4Global Gesture Recognition & Touchless Sensing (Technology, Application & Products) Market 2015-2020 2Secure Identity & Biometrics Association (SIBA) Names Troy Potter of L-3 National Security Solutions as Chairman 2Secure Identity & Biometrics Association (SIBA) Names Troy Potter of L-3 National Security Solutions as Chairman 3Secure Identity & Biometrics Association (SIBA) Names Troy Potter of L-3 National Security Solutions as Chairman 4Secure Identity & Biometrics Association (SIBA) Names Troy Potter of L-3 National Security Solutions as Chairman 5
... FL (Jan 3, 2012) Immune system abnormalities that mimic ... the amyloid precursor protein (APP), reports a research team from ... Silver Child Development Center. The study, conducted with ... APP fragment circulating in the blood could explain the aberrations ...
... Jeanne Baret disguised herself as a man to ... the first French circumnavigation of the globe. The expedition ... Antoine de Bougainville and was expected to take three ... French naval vessels; prejudice and custom prevented their participation ...
... 3 For the first time, a joint ... the American Society of Echocardiography have issued recommendations ... EAE/ASE Recommendations for Image Acquisition and Display Using ... issue of the Journal of the American ...
Cached Biology News:Autism may be linked to abnormal immune system characteristics and novel protein fragment 2Jeanne Baret, botanist and first female circumnavigator, finally commemorated in name of new species 2EAE/ASE 3D echocardiography image acquisition recommendations 2
(Date:6/26/2015)... June 26, 2015  SeraCare Life Sciences, a ... today announced that it has signed a Cooperative ... Cancer Institute (NCI), part of the National Institutes ... controls for cancer assays.  The CRADA will investigate ... quantitate control DNA biosynthetics spiked into a genomic ...
(Date:6/26/2015)... 26, 2015 /PRNewswire/ - iCo Therapeutics ("iCo" or "the ... all nominees listed in the management information circular ... 2015 Annual Meeting of Shareholders, held earlier today, ... the following 5 nominees proposed by management were ... until the Company,s next Annual Meeting of Shareholders ...
(Date:6/26/2015)... STRASBURG, Va. , June 26, 2015  A ... release two products made with synthetic rhino horn: beer ... in Vietnam . In response to ... oppose the manufacture, marketing and sale of synthetic rhino ... (IRF) and Save the Rhino International ...
(Date:6/26/2015)... ... June 26, 2015 , ... Claremont BioSolutions, ... technologies have been integrated into a sample prep module intended to enable real-time ... part of the NASA’s WetLab-2 Project. , On June 28, 2015, SpaceX CRS-7 ...
Breaking Biology Technology:SeraCare Life Sciences Signs CRADA with NCI to Advance Cancer Diagnostics 2SeraCare Life Sciences Signs CRADA with NCI to Advance Cancer Diagnostics 3iCo Therapeutics Announces Voting & Election Results from Annual Meeting of Shareholders 2iCo Therapeutics Announces Voting & Election Results from Annual Meeting of Shareholders 3Rhino Experts Oppose Synthetic Rhino Horn as Solution to Poaching Crisis 2Claremont BioSolutions’ SimplePrep™ Products Deployed in NASA Wetlab-2 Project Slated for June 28th Flight to International Space Station aboard SpaceX CRS-7 2Claremont BioSolutions’ SimplePrep™ Products Deployed in NASA Wetlab-2 Project Slated for June 28th Flight to International Space Station aboard SpaceX CRS-7 3
... MedTrust Online, announced today a strategic partnership with Scottsdale ... Arizona oncologists with cutting edge knowledge discovery and collaboration ... collaboration will enable more access to the latest therapies ... physicians to find and communicate with each other about ...
... Demonstrated at HIMSS 2009BERKELEY HEIGHTS, N.J., April 6 ... ADAT ), a worldwide provider of secure ... announced that it has integrated Authentidate,s Inscrybe(TM) Healthcare ... hospital patient discharges. "Hospitals are looking to automate ...
... PXS;,Nasdaq: PXSL ) will release its March 2009 ... 2009. Dr Alan Robertson will host an,investor teleconference the ... The teleconference will be on Thursday ... East Coast, 3.00pm U.S. West Coast). , , ...
Cached Biology Technology:MedTrust Online and Scottsdale Clinical Research Institute at Scottsdale Healthcare Announce Collaboration to Provide Cutting Edge Technology to Improve Patient Care 2Authentidate Teams with Nortel to Enhance Hospital Patient Discharge and Placement Processes 2Authentidate Teams with Nortel to Enhance Hospital Patient Discharge and Placement Processes 3Authentidate Teams with Nortel to Enhance Hospital Patient Discharge and Placement Processes 4