Navigation Links
New evidence of how high glucose damages blood vessels could lead to new treatments
Date:5/11/2009

called nitric oxide synthase, so that it makes more of the blood vessel dilator. But add more O-GlcNAc to the mix and it seems to beat phosphorylation to the punch so there is the opposite result. The longer O-GlcNAc levels were high, the worse the resulting problem, says Victor Lima, a graduate student at the University of Sao Paulo working with Dr. Tostes.

An animal model of hypertension seemed to confirm the finding that the more O-GlcNAc, the more blood vessels contract because these animals had higher O-GlcNAc levels. "Now we are trying to see why this is happening and what comes first. Is increased blood pressure leading to changed O-GlcNAc or are augmented levels of O-GlcNAc contributing to the change we see in the vasculature of hypertensives?" Dr. Tostes says. "If we know how this changes vascular function, we can understand some of the dysfunction that we see in diabetes."

To make sure they were targeting the O-GlcNAc sugar and not dealing with other effects of glucose on blood vessels, the researchers blocked the enzyme OGA, an enzyme that normally removes O-GlcNAc from proteins so they can revert to their normal state.

If the findings continue to hold true, drugs similar to those they use in the lab to inhibit OGA or OGT, the enzyme that adds O-GlcNAc to the protein, could one day help reduce the significant cardiovascular risk associated with diabetes, Mr. Lima says. "I think it looks very promising," Dr. Tostes adds.

Future studies will include blocking the pathway for adding O-GlcNAc in hypertensive animals to study the impact on blood pressure and vascular function.


'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Princeton geoscientist offers new evidence that meteorite did not wipe out dinosaurs
2. Evidence of the Lost World -- did dinosaurs survive the end Cretaceous extinctions?
3. Fossil evidence of missing link in the origin of seals, sea lions, walruses found in Canadian Arctic
4. New evidence explains poor infant immune response to certain vaccines, says MU researcher
5. New research reveals the earliest evidence for corn in the New World
6. Researchers find the earliest evidence of domesticated maize
7. Evidence of earliest known domestic horses found in Kazakhstan
8. Polar research reveals new evidence of global environmental change
9. DNA evidence is in, newly discovered species of fish dubbed H. psychedelica
10. New lab evidence suggests preventive effect of herbal supplement in prostate cancer
11. New study provides further evidence that apple juice can delay onset of Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New evidence of how high glucose damages blood vessels could lead to new treatments
(Date:7/24/2014)... A sake brewery has its own microbial terroir, meaning ... resemble those found in the product, creating the final ... the journal Applied and Environmental Microbiology . This ... census of a sake brewery. , Many sake ... author David A. Mills of the University of California, ...
(Date:7/24/2014)... College of Medicine of Yeshiva University have received ... Parkinson,s Research to translate a basic science finding into ... will test chemical compounds on a newly identified target ... on an underlying cause of the disease. , ... their symptoms, we are eager to stop or even ...
(Date:7/24/2014)... counterparts in humans, affect the connections between nerve cells ... hippocampus, an area of the brain that plays a ... memories. The results of the study have been published ... depends on the active communication between nerve cells, known ... into a dense network where they constantly relay signals ...
Breaking Biology News(10 mins):The microbes make the sake brewery 2Albert Einstein College of Medicine receives grant from the Michael J. Fox Foundation to fund drug discovery project targeting Parkinson's 2Albert Einstein College of Medicine receives grant from the Michael J. Fox Foundation to fund drug discovery project targeting Parkinson's 3A protein couple controls flow of information into the brain's memory center 2A protein couple controls flow of information into the brain's memory center 3A protein couple controls flow of information into the brain's memory center 4
... found that a protein that initiates a "quality control ... those cells damaged during duplication. This knowledge represents a ... appear in the current issue of Science. , The ... which works as a "quality control inspector." As normal ...
... years of remotely sensed imagery from the 1950s to 2002 ... more than 10,000 ponds in Alaska. The analysis, by University ... Journal of Geophysical Research, indicates that these landscape-level changes in ... and may have profound effects on climate and wildlife. , ...
... Chris Austin, assistant curator of herpetology at LSU's Museum ... biological sciences, recently discovered a new species of lizard ... along with colleague Indraneil Das from the Institute of ... will publish their findings and photos of the new ...
Cached Biology News:Mayo discovers protein as potential tactic to prevent tumors 2Shrinking ponds signal warmer, dryer Alaska 2LSU professor discovers new species 2
(Date:7/24/2014)... 24, 2014 SRI International has been awarded ... Institute of Allergy and Infectious Diseases (NIAID), part of ... of potential therapies for HIV infection and AIDS. The ... and AIDS and the complications and opportunistic infections associated ... sexual transmission of HIV. According to ...
(Date:7/24/2014)... 2014 Deep Research Report on Global ... and in-depth research report on Potassium Sulphate ... information, including its definition, classification, application, and industry ... the international market analysis, including China’s domestic market ... environment & economic situation analysis, the influence of ...
(Date:7/24/2014)... July 24, 2014 1000 balances – ... input on customers’ weighing needs and expertly narrows down ... of balances, scales or even terminals. , First, ... smallest weight (or select readability instead) and define the ... additional selection criteria narrows down the list to models ...
(Date:7/24/2014)... July 24, 2014  Spherix Incorporated (SPEX) -- an ... monetization of intellectual property, today announced that the Company ... June 30, 2014 on Monday, August 18, 2014 for ... a.m. ET on Monday, August 18, 2014 to discuss ... the company,s CEO, Anthony Hayes . ...
Breaking Biology Technology:National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 3Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 2Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 3Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 4Spherix Schedules Shareholder Update Call 2
... , , ... ("the Company"), a late-stage drug development company specialized in oncology and endocrinology, today reported financial ... . , , , ... - January 25, 2010: Updated results of a Phase 2 study related to the use, ...
... steel and triple that of the currently best synthetic ... one has thus far succeeded in producing the super ... and elastic fibers from the spider silk proteins stored ... the Technische Universitaet Muenchen (TUM) and the University of ...
... , May 12 /PRNewswire-Asia-FirstCall/ -- Yongye International,Inc. (Nasdaq: ... of Shengmingsu brand plant and animal nutrient,products in the People,s ... quarter ended March 31, 2010 . , , ... 100.5% to $24.9 million from the first quarter of, ...
Cached Biology Technology:Aeterna Zentaris Reports First Quarter 2010 Financial and Operating Results 2Aeterna Zentaris Reports First Quarter 2010 Financial and Operating Results 3Aeterna Zentaris Reports First Quarter 2010 Financial and Operating Results 4Aeterna Zentaris Reports First Quarter 2010 Financial and Operating Results 5Aeterna Zentaris Reports First Quarter 2010 Financial and Operating Results 6Aeterna Zentaris Reports First Quarter 2010 Financial and Operating Results 7Aeterna Zentaris Reports First Quarter 2010 Financial and Operating Results 8Investigating how spiders spin their silk, researchers unravel a key step 2Investigating how spiders spin their silk, researchers unravel a key step 3Yongye International Announces First Quarter 2010 Results 2Yongye International Announces First Quarter 2010 Results 3Yongye International Announces First Quarter 2010 Results 4Yongye International Announces First Quarter 2010 Results 5Yongye International Announces First Quarter 2010 Results 6Yongye International Announces First Quarter 2010 Results 7Yongye International Announces First Quarter 2010 Results 8Yongye International Announces First Quarter 2010 Results 9Yongye International Announces First Quarter 2010 Results 10Yongye International Announces First Quarter 2010 Results 11Yongye International Announces First Quarter 2010 Results 12Yongye International Announces First Quarter 2010 Results 13Yongye International Announces First Quarter 2010 Results 14
... GCpro Taq DNA Polymerase is a ... advantages for all PCR applications. GCpro Taq ... clone expressed in E. coli, containing the ... The enzyme includes a highly processive 5'-3' ...
Ps-Aeruginosa (IgG) -Ab EIA Sample Size: 100 l...
...
Automated -80° C sample library for microplates and cryotube racks in SBS format; for integration into automated processes....
Biology Products: