Navigation Links
'New' estrogen receptor found to be key player in tamoxifen resistance
Date:10/29/2008

d biophysics and director of GUMC's Biomedical Graduate Research Organization. "It identifies a new player and shows some of its downstream signaling and how this affects responsiveness to tamoxifen in these breast cancers."

The findings came about after the research team developed the first cell culture model of tamoxifen-resistant, invasive lobular carcinoma. To do this, they took cells of this subtype and exposed them to low amounts of tamoxifen and allowed the cells to adapt to the agent. The researchers slowly increased the tamoxifen to match the dosage that a woman taking the drug would be exposed, and during this 10-month process, watched the cells develop resistance to the drug.

"Initially the cells were sensitive to tamoxifen, but as the dose increased, the sensitive cells died off, and the tumor repopulated itself with resistant cells," Riggins says.

During the experiment, the investigators measured gene expression, and were able to track higher and higher expression of the gamma estrogen-related receptor subtype.

"Clearly, the gamma estrogen-related receptors, which have a role in cell metabolism, are stimulating cancer growth, and it is possible that tamoxifen is activating this receptor, " Riggins says.

If alpha estrogen receptors can be used as a drug target, then perhaps the gamma estrogen-related receptor subtype can as well, she adds.


'/>"/>

Contact: Karen Mallet
km463@georgetown.edu
215-514-9751
Georgetown University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New, more direct pathways from outside the cell-to-cell nuclei discovered
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. New molecular regulators of hyperthyroidism and goiter
4. Newly created cancer stem cells could aid breast cancer research
5. Adding up renewable energy
6. Unravelling new complexity in the genome
7. New study warns limited carbon market puts 20 percent of tropical forest at risk
8. New study examines how rearing environment can alter navigation
9. News tips from the Journal of Neuroscience
10. Dominant cholesterol-metabolism ideas challenged by new research
11. Researchers identify proteins involved in new neurodegenerative syndrome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2015)... , March 23, 2015   HOYOS Labs ... management company, today announced that the Company will demonstrate ... both enterprise and consumers at Connect:ID on March 23 ... HOYOS Labs will highlight the IEEE Biometric Open ... ; and enterprise access control system. BOPS was ...
(Date:3/20/2015)... Mar. 20, 2015 Research and Markets ... of the "India Sensors Market Forecast and ... The sensor market is projected to grow ... Consumer electronics, automotive, industrial and healthcare sectors ... the country. In addition, adoption of MEMS technology ...
(Date:3/20/2015)... , Mar. 19, 2015 Research and Markets ... "Iris Biometrics - Global Strategic Business Report" report ... markets for Iris Biometrics in US$ Thousands. The report provides ... , Japan , Europe ... , and Latin America . ...
Breaking Biology News(10 mins):HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 2Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 4Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 5
... wounds could identify the superbug quickly and help prevent infection ... whether wounds or lesions are infected with bacteria and if ... of Edinburgh in collaboration with NHS Lothian, works by taking ... using a strip with electrical sensors that can detect MRSA. ...
... This press release is available in German ... vessels, is a complex process during which different signalling proteins ... growth factor VEGF and the Notch signalling pathway both play ... binding to its receptor, VEGFR2, while the Notch signalling pathway ...
... with a deadly form of brain cancer is linked ... The University of Nottingham have discovered. The study ... Centre as part of a European collaboration could potentially ... to identify youngsters who are at the highest risk ...
Cached Biology News:Tiny electrical sensors could signal faster MRSA diagnosis 2Culprit behind unchecked angiogenesis identified 2Genetic abnormality offers diagnostic hope for children's cancer 2Genetic abnormality offers diagnostic hope for children's cancer 3
(Date:5/5/2015)... Psyche Systems Corporation and Luminate Health have ... platform that helps labs comply with new federal HHS ... way patients engage with these results, and improves provider ... a HIPAA-compliant digital platform that gives labs an easy ... lab results, and uniquely connects labs, physicians, and patients ...
(Date:5/5/2015)... NEW YORK , May 5, 2015 /PRNewswire/ ... today announced that Andrew Gengos , President and ... on May 7, 2015. DATE:  Thursday, May ... LINK:  http://VirtualInvestorConferences.com > click the ... will be a live, interactive online event where ...
(Date:5/5/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/4r95kr/clinical ) ... Laboratory, Molecular Diagnostics and Genomic Testing Services Market ... Version" report to their offering. ... molecular diagnostics and pharmacogenics hold the promise of ... is moving out of the national and regional ...
(Date:5/5/2015)... (PRWEB) May 05, 2015 GEA ... last week as recipients of the INTERPHEX Exhibitor ... recognition of their Portable, Continuous, Miniature and Modular ... a small footprint, continuous processing equipment, smart control ... process API powders and inactive ingredients into bulk ...
Breaking Biology Technology:Psyche Systems Corporation Forms Strategic Alliance with Luminate Health to Provide First-of-its-kind Patient Access Solution 2Psyche Systems Corporation Forms Strategic Alliance with Luminate Health to Provide First-of-its-kind Patient Access Solution 3ImmunoCellular Therapeutics to Webcast Live at VirtualInvestorConferences.com on May 7 2European Clinical Laboratory, Molecular Diagnostics and Genomic Testing Services Market 2015-2019 2GEA Pharma Systems, G-CON Manufacturing and Pfizer Consortium Receives Best Technology Innovation Award at INTERPHEX 2015 2GEA Pharma Systems, G-CON Manufacturing and Pfizer Consortium Receives Best Technology Innovation Award at INTERPHEX 2015 3
... Pharmaceutical Inc. (Nasdaq: BMRN ) today announced that ... company update at the Deutsche Bank 34th Annual Health Care ... p.m. ET. Interested parties may access a live audio ... the BioMarin website, www.BMRN.com . A ...
... platform for treatment of Spinal Muscular Atrophy SOUTH PLAINFIELD, ... Inc. (PTC) and the Spinal Muscular Atrophy (SMA) Foundation ... which the SMA Foundation will provide up to $8.5 ... second continuation of the collaboration to fund a series ...
... AND STRENGTHENS ITS SENIOR MANAGEMENT TEAM , ... Systems, Inc. (OTC Bulletin Board: OMCM.OB), a leader in ... today announced that it has strengthened its European presence ... Summa. As Executive Vice President, Europe & Asia/Pacific based ...
Cached Biology Technology:BioMarin to Present at the Deutsche Bank Health Care Conference 2PTC Therapeutics and Spinal Muscular Atrophy Foundation Announce $8.5 Million Small Molecule Development Collaboration 2PTC Therapeutics and Spinal Muscular Atrophy Foundation Announce $8.5 Million Small Molecule Development Collaboration 3OmniComm Systems Appoints EDC Veteran Dr. Wolfgang Summa to Executive Vice President, Europe & Asia/Pacific 2OmniComm Systems Appoints EDC Veteran Dr. Wolfgang Summa to Executive Vice President, Europe & Asia/Pacific 3
100 ug affinity purified rabbit anti-JIP-1 polyclonal antibody. Reacts with mouse and rat. Perform well in Western blotting. Other applications have not been tested. Storage Temperature: -20C Shi...
Melanoma Antigen, Family C, 1 (MAGEC1) Rabbit anti-Human Polyclonal Antibody Immunogen: Synthetic peptide - KLH conjugated Family: New Recommended Storage: Long term: -20C; Short term: +4...
X box-binding protein 1...
Mouse monoclonal [AE3] to Cytokeratin 1 - 8, prediluted ( Abpromise for all tested applications). Antigen: Tissue / cell preparation - Human epidermal cells. Entrez GeneID: 140807 Swiss P...
Biology Products: