Navigation Links
'New' estrogen receptor found to be key player in tamoxifen resistance
Date:10/29/2008

unclear whether tamoxifen is very effective in this cancer, and has been a point of debate among clinicians," Riggins says. "This study is a good first step toward clarifying the role that tamoxifen resistance apparently plays in treatment of invasive lobular cancer."

Invasive lobular carcinoma, which accounts for 15 percent of newly diagnosed invasive breast cancers diagnosed each year, appear under the microscope as long, very thin tumors actually a single stream of cancer cells that line up in a row. That makes them much harder to diagnose than the more common cancer type, invasive ductal carcinoma, in which tumors form more discrete lumps.

But what the researchers found in invasive lobular carcinomas the specific cancer they studied - may also be true of tamoxifen resistance in other cancer types," she said "No one has looked for gamma estrogen-related receptors in tamoxifen resistance in invasive ductal carcinoma."

In addition to its use as a cancer preventive, tamoxifen is approved to treat both early and advanced breast cancer that is estrogen-receptor positive. (Estrogen-receptor positive cancer means that estrogen is the primary fuel that promotes cancer development and growth.) Tamoxifen binds to the estrogen receptors (alpha) that stud tumors and other breast tissue, not allowing estrogen to latch on and turn on a program of growth inside the cells. But it is estimated that 30 to 50 percent of breast cancer patients eventually become resistant to tamoxifen.

"The magnitude of this health issue is huge. More than 178,000 women will be diagnosed this year with invasive breast cancer, and 70 percent of them will have estrogen receptor-positive tumors," Riggins says. "It is clear that we need to understand why this resistance occurs."

"This is a very nice story of tamoxifen resistance in a somewhat under-investigated group of breast cancers," says the study's senior investigator, Robert Clarke, Ph.D., professor of oncology, physiology an
'/>"/>

Contact: Karen Mallet
km463@georgetown.edu
215-514-9751
Georgetown University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New, more direct pathways from outside the cell-to-cell nuclei discovered
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. New molecular regulators of hyperthyroidism and goiter
4. Newly created cancer stem cells could aid breast cancer research
5. Adding up renewable energy
6. Unravelling new complexity in the genome
7. New study warns limited carbon market puts 20 percent of tropical forest at risk
8. New study examines how rearing environment can alter navigation
9. News tips from the Journal of Neuroscience
10. Dominant cholesterol-metabolism ideas challenged by new research
11. Researchers identify proteins involved in new neurodegenerative syndrome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... There is evidence that under the normal ... and development, maintain neuronal environment, and exhibit ... and neurodegenerative disease. Previous studies have found ... cells after chemical induction have reduced viability, ... application. Prof. Xiaodong Yuan, Kailuan General Hospital, ...
(Date:7/11/2014)... that let nerve cells send out electrical signals, Johns ... tactic that may offer a new way to protect ... responsible way. , Their findingthat naturally occurring insect ... for a closely related onesuggests that insecticides can be ... like bees. A summary of the research, led by ...
(Date:7/10/2014)... 27, 2014  The American Academy of Forensic ... Standards and Technology (NIST) and the Department of ... and forensic science expert members to the Forensic ... element of the NIST,s Organization of Scientific Area ... first appointments made to the new FSSB that ...
Breaking Biology News(10 mins):Potent spider toxin 'electrocutes' German, not American, cockroaches 2Potent spider toxin 'electrocutes' German, not American, cockroaches 3Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 2Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 3
... we,ve been told, eliminating or severely limiting fats from ... in patients suffering from heart failure, a study at ... Results from biological model studies conducted by assistant professor ... researchers, demonstrate that a high-fat diet improved overall mechanical ...
... WASHINGTON The Chesapeake Bay Program is a ... jurisdictions in the bay watershed to oversee the restoration ... the extent of pollutants -- such as nitrogen, phosphorus, ... from the National Research Council assesses the framework used ...
... a researcher at the Royal Swedish Academy of Sciences, Margareta ... permafrost. "The changes we see are dramatic. And ... from the norm when compared with a longer term perspective", ... of the globe that is warming up fastest today. Measurements ...
Cached Biology News:Damaged hearts pump better when fueled with fats 2Chesapeake Bay program's 2-year milestones improve upon past strategies, but accounting of progress remains a challenge 2A new research report shows effects of climate change in the Arctic are more extensive than expected 2A new research report shows effects of climate change in the Arctic are more extensive than expected 3
(Date:7/10/2014)... 2014 Product and process impurities ... abundance and are often “lost in the noise,” ... Join presenters Dr. Rowel Tobias, Senior Scientist, Protein ... Head of Quality at Nanotherapeutics, Inc., to lear ... speed detection and quantitation while achieving the required ...
(Date:7/10/2014)... (PRWEB) July 10, 2014 Terascala, the ... announced that Alan Swahn, a former vice president of ... team as vice president of marketing. Terascala’s software when ... and NetApp create the highest performance and most reliable ... appointed to guide Terascala’s channel expansion and broaden its ...
(Date:7/10/2014)... OMICS Group’s 5th International conference and exhibition ... at Double Tree by Hilton Beijing, China is all ... & Bioanalytical research methods only to facilitate improved living ... Dr. Srinubabu Gedela, MD of OMICS Group Inc has ... one in bringing a unique and international mix of ...
(Date:7/10/2014)... , July 10, 2014  Franciscan ... use of capnography for respiratory monitoring outside ... of healthcare leaders in embracing state-of-the-art patient ... effectively patients are breathing and can alert ... By measuring the amount of carbon dioxide ...
Breaking Biology Technology:Novel Ms Techniques Speed Detection of Biopharmaceutical Product and Process Impurities, New Webinar Hosted by Xtalks 2Terascala Expands Executive Team 2Terascala Expands Executive Team 3A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2
... has succeeded in significantly increasing the sensitivity of the ... on this topic at Delft University of Technology on ... and astronomers from around the world are currently working ... of 66 advanced telescopes which will be placed at ...
... Iceland, February 3 deCODE genetics,(Nasdaq: DCGN ) ... letter from,the Nasdaq Listing Qualifications Panel (the "Panel") stating ... stock from the Nasdaq Global,Market to the Nasdaq Capital ... Wednesday, February 4, 2009. The Nasdaq Capital Market, which ...
... DHA (docosahexaenoic acid) omega-3 innovator and maker of the ... today that it has entered into a license agreement ... is a process widely used in food manufacturing that ... the nutritional value, shelf-life and flavor of the finished ...
Cached Biology Technology:Nanotechnology makes supertelescopes much more sensitive 2deCODE Announces Transfer of the Listing of its Common Stock from Nasdaq Global Market to Nasdaq Capital Market 2deCODE Announces Transfer of the Listing of its Common Stock from Nasdaq Global Market to Nasdaq Capital Market 3Martek, General Mills Collaborate on Microencapsulation Technology for Food Applications 2Martek, General Mills Collaborate on Microencapsulation Technology for Food Applications 3
Features , Designed to assist users in applying domed caps to tube strips and plates , Minimises the pressure required to seal the caps effectively , Enables multiple tubes to be sealed simultaneousl...
Lysozyme C (W-20)...
... ventilated and BR4i refrigerated multifunction centrifuges are equally ... at a low sound level with a large ... Their AUTO-LOCK rotor exchange system without tools ensures ... within seconds. Instant rotor exchange (5 ...
... X-Gal (5-bromo-4-chloro-3-indoyl-beta-D-galactopyranoside) is a ... identify recombinant plasmids. In ... and IPTG, lac ... blue, whereas recombinant colonies ...
Biology Products: