Navigation Links
New era of pain drugs advanced by Barrow researcher
Date:2/9/2010

Research led by a scientist at Barrow Neurological Institute at St. Joseph's Hospital and Medical Center has opened the door for the advancement of a new category of painkillers, called TRPV1 antagonists.

These drugs block the transient receptor potential vannilloid-1 (TRPV1) channel, which is the same receptor responsible for the sensation of hotness from hot peppers. However, clinical trials have revealed that TRPV1 antagonists cause hyperthermia- a dangerous, fever-like rise in body temperature.

Research has shown that TRPV1 can be activated by several stimuli, including "pepper-like" chemicals, high temperatures and protons. The same channel is responsible for pain caused by these diverse stimuli. For a number of years scientists have focused on the development of TRPV1 antagonists, but have been stymied by the dangerous hyperthermia side effect.

The groundbreaking project to eliminate the side effect was led by Andrej A. Romanovsky, MD, PhD, at Barrow and included researchers from Amgen and Arizona State University. Their findings, published last month in the in the Journal of Neuroscience, show the side effect can be avoided.

"We think we have found a recipe for making TRPV1 antagonists that do not have this fever-like side effect," says Dr. Romanovsky. "If an antagonist does not block activation of the TRPV1channel by protons, it does not cause hyperthermia." This research suggests that drugs that are being developed should be designed not to block the proton activation of TRPV1.

Even though pain is a major clinical problem and the search for new painkillers has been conducted by pharmaceutical companies and academic scientists for many years, the TRPV1 channel is one of the very few novel targets for pain identified so far. To continue developing TRPV1 antagonists, it was necessary to find a way to eliminate their hyperthermic side effect. "And, this is exactly what our study did," Dr. Romanovsky said.

Scientists believe that this new generation of painkillers will be effective in treating pain related to a number of conditions including cancer, AIDS, migraines and diabetes.


'/>"/>

Contact: Lynne Reaves
Lynne.Reaves@chw.edu
602-406-4734
St. Joseph's Hospital and Medical Center
Source:Eurekalert

Related biology news :

1. Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
2. Socioeconomic position associated with effectiveness of HIV drugs
3. Using green chemistry to deliver cutting-edge drugs
4. MIT model could improve some drugs effectiveness
5. Plants can be used to study how and why people respond differently to drugs
6. Insulins brain impact links drugs and diabetes
7. Scientists unveil structure of molecular target of many drugs
8. Market testing of dietary supplements and drugs underscores value of USPs public health programs
9. MIT: Remote-control nanoparticles deliver drugs directly into tumors
10. Club drugs inflict damage similar to traumatic brain injury
11. Cheaper drugs now closer to realization with new DropArray technology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2016)... 20, 2016 The new GEZE ... compact web-based "all-in-one" system solution for all door components. ... or the door interface with integration authorization management system, ... systems. The minimal dimensions of the access control and ... building installations offer considerable freedom of design with regard ...
(Date:3/31/2016)... Florida , March 31, 2016 ... ) ("LegacyXChange" or the "Company") LegacyXChange ... potential users of its soon to be launched online ... ( https://www.youtube.com/channel/UCyTLBzmZogV1y2D6bDkBX5g ) will also provide potential ... use of DNA technology to an industry that is ...
(Date:3/22/2016)... PROVO and SANDY, Utah ... Ontario (NSO), which operates the highest sample volume laboratory ... and Tute Genomics and UNIConnect, leaders in clinical sequencing ... announced the launch of a project to establish the ... panel. NSO has been contracted by ...
Breaking Biology News(10 mins):
(Date:5/26/2016)... San Diego, CA (PRWEB) , ... May 26, ... ... assay development and manufacturing company, today announced several positive developments that position the ... As a result of the transaction, Craig F. Kinghorn has been appointed ...
(Date:5/25/2016)... ... May 25, 2016 , ... ... variety of fracture-specific plating options designed to address fractures of the distal tibia ... solutions. , The Acumed Ankle Plating System 3 is composed of seven plate ...
(Date:5/25/2016)... ... May 25, 2016 , ... WEDI, the nation’s leading authority ... announced that Charles W. Stellar has been named by the WEDI Board of Directors ... 2016. As an executive leader with more than 35 years of experience in healthcare, ...
(Date:5/24/2016)... --  MedyMatch Technology Ltd ., the data analytics healthcare company ... tools in the emergency room, announced today that it has ... Industries (IATI) BioMed Conference. The Conference is ... Life Sciences and Technology Week, and is being held May ... Tel Aviv, Israel . Gene Saragnese , ...
Breaking Biology Technology: