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New enzyme targets for selective cancer therapies
Date:8/22/2014

aminidase isoenzyme in cancer cells isolated from patients. Cairo approached them about testing a compound his team identified last year, which was selective for the same isoenzyme.

"I expected it would do something, but I didn't know it would be that striking. It came out beautifully," Cairo said.

The U of A team is already working on improving the compound, and developing and testing new and existing inhibitors using a panel of in vitro assays they developed.

"We've been working on these enzymes for about five years. Validation of our strategydesign of a selective neuraminidase inhibitor and application in a cell that overexpresses that enzymeis an achievement for us."


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Contact: Bryan Alary
bryan.alary@ualberta.ca
780-492-0436
University of Alberta
Source:Eurekalert  

Page: 1 2 3

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