Navigation Links
New electrostatic-based DNA microarray technique could revolutionize medical diagnostics
Date:6/30/2008

BERKELEY, CA The dream of personalized medicine in which diagnostics, risk predictions and treatment decisions are based on a patient's genetic profile may be on the verge of being expanded beyond the wealthiest of nations with state-of-the-art clinics. A team of researchers with the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) has invented a technique in which DNA or RNA assays the key to genetic profiling and disease detection can be read and evaluated without the need of elaborate chemical labeling or sophisticated instrumentation. Based on electrostatic repulsion in which objects with the same electrical charge repel one another the technique is relatively simple and inexpensive to implement, and can be carried out in a matter of minutes.

"One of the most amazing things about our electrostatic detection method is that it requires nothing more than the naked eye to read out results that currently require chemical labeling and confocal laser scanners," said Jay Groves, a chemist with joint appointments at Berkeley Lab's Physical Biosciences Division and the Chemistry Department of the University of California (UC) at Berkeley, who led this research. "We believe this technique could revolutionize the use of DNA microarrays for both research and diagnostics."

Groves, who is also a Howard Hughes Medical Institute (HHMI) investigator, and members of his research group Nathan Clack and Khalid Salaita, have published a paper on their technique in the journal Nature Biotechnology, which is now available online. The paper is entitled "Electrostatic readout of DNA microarrays with charged microspheres."

In their paper, Groves, Clack, and Salaita describe how dispersing a fluid containing thousands of electrically-charged microscopic beads or spheres made of silica (glass) across the surface of a DNA microarray and then observing the Brownian motion of the spheres provides measurem
'/>"/>

Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory
Source:Eurekalert  

1

GOOD

Page: 1 2 3 4

Related biology news :

1. Microarray sequence capture speeds large-scale resequencing of targeted genomic regions
2. New technique can be breakthrough for early cancer diagnosis
3. University of Leicester scientists discover technique to help friendly bacteria
4. New technique reveals subtle force-induced changes in biomolecules conformation
5. New magnetic separation technique might detect multiple pathogens at once
6. New technique captures chemical reactions in a single living cell at unprecedented resolution
7. Software Techniques Inc. Selects M2SYS Fingerprint Software to Meet Continuous Growth and Demand for Desktop Biometric Time & Attendance Solutions
8. New X-ray technique targets terrorists and tumors
9. Technique controls nanoparticle size, makes large numbers
10. New technique could dramatically lower costs of DNA sequencing
11. New techniques create butanol

Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New electrostatic-based DNA microarray technique could revolutionize medical diagnostics
New electrostatic-based DNA microarray technique could revolutionize medical diagnostics
(Date:11/26/2009)...ogists have at last worked out a way of using reco...of bird populations. This is the first time sound ...lated into accurate estimates of bird species, pop...he British Ecological Society,s Journal of Applie...ld lead to a major advance in our ability to monit...
(Date:11/26/2009)...Heidelberg, 27 November 2009 What are the bare es...quired to produce a cell that can survive on its o...l, and understand how an entire organism functions... that scientists in a partnership between the Euro...berg, Germany, and the Centre de Regulacio Genmica...
(Date:11/25/2009)...lin, a hormone produced in the stomach, may be use... of Parkinson,s disease, Yale School of Medicine r... issue of the Journal of Neuroscience . , Parki...mine neurons in an area of the midbrain known as t...mine production. Reduced production of dopamine i...
Breaking Biology News(10 mins):Ecologists sound out new solution for monitoring cryptic species 2First-ever blueprint of a minimal cell is more complex than expected 2First-ever blueprint of a minimal cell is more complex than expected 3Hormone ghrelin can boost resistance to Parkinson's disease 2Dental Plaque Buildup May Raise Heart Risk in Black Men 58791 1Dental Plaque Buildup May Raise Heart Risk in Black Men 58791 2NIH recognizes engineering professors innovative research with major award 58789 1NIH recognizes engineering professors innovative research with major award 58789 2NIH recognizes engineering professors innovative research with major award 58789 3UMCES researchers launch freshwater marsh study 10246 1
... Engineers at Washington University in St. Louis, ...technologies, have determined the importance of mi...teria to breakdown organic matter in the absence o...ell of money, as farmers long have termed manure, ... of anaerobic digestion is methane, which can be c...
..., DALLAS April 16, 2008 A new study in mice indi...causes, is the trigger for developing metabolic sy...creases an individuals chances of developing insul... 2 diabetes. , How and where the body stores exc...etermining a persons risk of developing metabolic ...
... AUSTIN, TexasEarly diagnosis of a heart attack ma... and a new nano-bio-chip, a multi-institutional te...t Austin reported at a recent meeting of the Ameri...io-chip assay could some day be used to analyze a ...tists office or at a neighborhood drugstore, helpi...
Other Biology News:Biogas production is all in the mixing 2Biogas production is all in the mixing 3How and where fat is stored predicts disease risk better than weight 2How and where fat is stored predicts disease risk better than weight 3Saliva can help diagnose heart attack, study shows 2
(Date:11/30/2009)...2009 An international team of applied scientists ...ave demonstrated compact, multibeam, and multi-wav...he light spectrum (infrared). By contrast, typical... wavelength. The innovative multibeam lasers have ...emical sensing pollution monitoring, optical wirel...
(Date:11/30/2009)..., N.Y., Nov. 30 Good Publication P...publication of company-sponsored medical research,...dical Journal (BMJ). "The publication of GPP2 in B...iding support and guidance for industry sponsored ...he peer-reviewed medical literature," said Chris G...
(Date:11/30/2009)... BioMarin Pharmaceutical...od and Drug Administration (FDA) has granted orpha...P), amifampridine phosphate, for the rare autoimmu...). 3,4-DAP has previously received orphan drug de...Committee for Medicinal Products for Human Use of ...
(Date:11/30/2009)...ovember 30 ApaTech, the rapidly gr...astest growing,Biotech/Pharmaceutical/Medical Tech...nology Fast 500 for EMEA (Europe, Middle East and ...n a companies, five-year revenue growth,for which...eriod. This,achievement places ApaTech 9th overall...
Breaking Biology Technology:Scientists demonstrate multibeam, multi-functional lasers 2ISMPP Announces Publication of Good Publication Practice for Communicating Company-Sponsored Medical Research: GPP2 Guidelines Published in the BMJ 2ISMPP Announces Publication of Good Publication Practice for Communicating Company-Sponsored Medical Research: GPP2 Guidelines Published in the BMJ 3FDA Grants Orphan Drug Designation for 3,4-DAP for LEMS 2FDA Grants Orphan Drug Designation for 3,4-DAP for LEMS 3FDA Grants Orphan Drug Designation for 3,4-DAP for LEMS 4ApaTech is Europe's Fastest Growing Lifescience Company 2ApaTech is Europe's Fastest Growing Lifescience Company 3ApaTech is Europe's Fastest Growing Lifescience Company 4
...FAYETTE, Ind. - A Purdue University researcher has...he virus that causes SARS and could lead to a trea... 2003 led to hundreds of deaths and thousands of i...id Arun Ghosh, the Purdue professor that led the m...y a threat, there is the concern that SARS could r...
...TON, Dec. 23 - Deriving plentiful electricity from...ense implications for energy, technology, and clim...Optics Express , the Optical Society,s (OSA) open-...h to solar cells: lacing them with nanoscopic meta...e, this approach has the potential to greatly impr...
...ELT, Md. - Engineers at the University of Idaho ha...ed in upcoming NASA missions that will study the E...al guidance of a grant technical officer Pen-Shu Y...ht Center, Greenbelt, Md., the engineering team at...Advanced Microelectronics Biomolecular Research (C...
Other Biology Technology:Purdue researcher invents molecule that stops SARS 2Purdue researcher invents molecule that stops SARS 3Enhancing solar cells with nanoparticles 2New one-of-a-kind technology will fly on 2 NASA missions 2New one-of-a-kind technology will fly on 2 NASA missions 3
EZ-DEWAX READY-TO-USE from BioGenex
...ycler unit is an inexpensive personal or mini ther...ess. Lightweight, with a small footprint, it can b...luding the researcher's desk. , The Gene Cycl...ho do not have access to a large laboratory therma...
Radiant Red Fluorescent RNA Stain, 10 ml from Bio-Rad
EZ-Chip from Upstate
Biology Products: