Navigation Links
New edition of laboratory manual includes cutting-edge techniques to study gene regulation
Date:12/19/2008

COLD SPRING HARBOR, N.Y. (Dec. 19, 2008) With the growing availability of genome sequence data for a variety of organisms, many scientists are now focusing on factors that govern the expression of individual genesan important field of molecular biology known as transcriptional regulation. A new edition of a popular laboratory manual on transcriptional regulation has just been published by Cold Spring Harbor Laboratory Press. The manual, Transcriptional Regulation in Eukaryotes: Concepts, Strategies, and Techniques (Second Edition), will help molecular biologists decipher the sophisticated signaling networks that turn genes on and off in more complex organisms, including humans.

"In the nine years since the first edition was published, the transcriptional regulation field has witnessed dramatic changes that arguably are as significant as the emergence of molecular cloning techniques in the 1970s," write the authors in the preface to the new edition.

The first edition of Transcriptional Regulation in Eukaryotes was published in 2000, shortly before the draft sequences of the human genome were announced. Since that time, substantial effort has been put forth to understand genome organization in the context of chromatin and the role of that chromatin in gene regulation.

The second edition has been completely rewritten to discuss recent advances in the field, especially those related to chromatin biochemistry, providing a comprehensive source of conceptual and practical information on how to study the regulation of a newly isolated gene and the biochemical characteristics of a new transcription factor. In addition to chromatin-based techniques such as chromatin immunoprecipitation (ChIP), the new edition incorporates RNA interference (RNAi), mass spectrometry, and bioinformatic and experimental methods that exploit genome sequencing information to examine gene regulation on a more global scale. It includes both strategic information and step-by-step protocols that are appropriate for a wide range of experimental questions.

The new edition was written by three experienced investigators: Michael F. Carey (University of California, Los Angeles), Craig L. Peterson (University of Massachusetts Medical School, Worcester), and Stephen T. Smale (University of California, Los Angeles). Carey and Smale wrote the first edition. Peterson is a new author on the second edition; he provides expertise on chromatin, a major emphasis of the new edition.

Transcriptional Regulation in Eukaryotes is geared towards graduate students, postdocs, physician-scientists, and others entering the field, but is also valuable for established investigators who need to examine new aspects of specific regulatory systems. Furthermore, it will serve as a powerful textbook for advanced instruction in molecular biology.


'/>"/>

Contact: Ingrid Benirschke
benirsch@cshl.edu
619-275-6021
Cold Spring Harbor Laboratory
Source:Eurekalert  

Related biology news :

1. Expeditions reveal gulf of Californias deep sea secrets, as well as human imprints
2. Research expedition on corals and global warming: Aug. 17-26 in Puerto Rico
3. Scripps expedition provides new baseline for coral reef conservation
4. NOAA science story tips -- AAAS 2008 edition
5. Antarctic expedition provides new insights into the role of the Southern Ocean for global climate
6. New edition of a classic molecular biology textbook from CSHL Press and Benjamin Cummings
7. Scientist-evangelical Alaska expedition
8. Gene therapy corrects sickle cell disease in laboratory study
9. Very cold ice films in laboratory reveal mysteries of universe
10. Cold Spring Harbor Laboratory scientists trace a novel way cells are disrupted in cancer
11. Story tips from the Department of Energys Oak Ridge National Laboratory, September 2008
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New edition of laboratory manual includes cutting-edge techniques to study gene regulation
(Date:3/23/2017)... 2017 The report "Gesture Recognition and Touchless Sensing Market ... - Global Forecast to 2022", published by MarketsandMarkets, the market is expected to ... between 2017 and 2022. Continue Reading ... ... ...
(Date:3/20/2017)... At this year,s CeBIT Chancellor Dr. Angela ... The Chancellor came to the DERMALOG stand together with the Japanese Prime ... partner country. At the largest German biometrics company the two government leaders ... iris recognition as well as DERMALOG´s multi-biometrics system.   ... ...
(Date:3/9/2017)... and MOUNTAIN VIEW, Calif. ... "Eating Well Made Simple," and 23andMe , the ... guide better food choices.  Zipongo can now provide customers ... food preferences, health goals and biometrics, but also genetic ... food choices. Zipongo,s personalized food decision support ...
Breaking Biology News(10 mins):
(Date:4/21/2017)... (PRWEB) , ... April 21, 2017 , ... Having worked ... a year, Formaspace is pleased to introduce it to top lab design architects from ... CEO Jeff Turk and VP of Industrial Design and Engineering Greg Casey will be ...
(Date:4/21/2017)... ... April 21, 2017 , ... Frederick Innovative Technology Center, Inc. ... bio and technology start-ups, is hosting “Celebration Friday” (a festive gathering highlighting client ... with libations and networking at 3:30 p.m. at FITCI’s 4539 Metropolitan Court location, ...
(Date:4/20/2017)... , April 20, 2017  Eli Lilly and ... 2 data evaluating galcanezumab for the prevention of migraine ... which will take place April 22-28, 2017, in ... present four abstracts at AAN, including safety and patient ... factors associated with a reduction in monthly migraine headache ...
(Date:4/20/2017)... , April 20, 2017 /PRNewswire/ - Prometic Life Sciences Inc. ... new results at the International Liver Congress ("ILC") 2017 of ... in Amsterdam on the positive effects ... mouse model of obesity and metabolic syndrome. ... According to Dr. Lyne Gagnon, Vice-President of ...
Breaking Biology Technology: