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New edition of a classic molecular biology textbook from CSHL Press and Benjamin Cummings

A new edition of the most widely used undergraduate textbook in molecular biology, Molecular Biology of the Gene, has just been released. It incorporates the latest in research and technological advances while retaining the distinctive characteristics of earlier editions that have made this a superior textbook for generations of students. Written by six authors with outstanding teaching and research credentials, the book will also be useful to professional scientists looking for a concise, up-to-date summary of the field. It was jointly published by Cold Spring Harbor Laboratory Press and Benjamin Cummings, an imprint of Pearson Education.

The first edition, which appeared in 1965, was written by James D. Watson. More recent editions of the book have been co-authored by Watson and five highly respected biologists to provide current, comprehensive, and authoritative coverage of this fast-changing discipline. These additional authors are Tania A. Baker (MIT), Stephen P. Bell (MIT), Alexander Gann (CSHL), Michael Levine (UC Berkeley), and Richard Losick (Harvard).

Now in its sixth edition, Molecular Biology of the Gene has been thoroughly revised. Content updates have been made to every chapter, and medical insights that have emerged from our understanding of basic molecular biology have been included. Two all-new chapters discuss regulatory RNAs (Chapter 18) and genomics and systems biology (Chapter 20). These chapters focus on RNAi and microRNAs, the opportunities offered by the new generation of genome technologies, and the elucidation of gene regulatory networks.

The twenty-two chapters offer balanced coverage of prokaryotic and eukaryotic systems, and are divided into five major sections. The chapters in Part 1 provide a historical basis for the field and include descriptions of fundamental chemical concepts. Part 2 covers the structures of DNA, RNA, and chromatin, as well as the maintenance of genetic material through replication, recombination, and repair. A comprehensive survey of transcription, splicing, and translation is offered in Part 3, and the regulation of these processes is discussed in Part 4. Finally, Part 5 presents standard techniques and model organisms commonly used in molecular biology studies.

Also new to the book are a series of color-coded boxes that describe key experiments, techniques, medical connections, and advanced concepts. These boxes help to support the narrative and to clarify key concepts throughout the book.

Web Animation icons are also placed throughout the text, and these direct students to the expanded companion Web site ( This Web site contains interactive tutorials, animations, critical-thinking exercises, and a glossary, which are designed to reinforce fundamental concepts and to help visualize complex concepts.

Supplementary instructor resources, including a CD-ROM and transparency acetates, are also available. The dual-platform CD-ROM contains high-resolution files of all art and tables from the book in JPEG and PowerPoint formats, as well as answers to the critical-thinking questions posed to students on the companion Web site. The transparencies feature approximately 300 four-color illustrations from the text as selected by the authors.


Contact: Ingrid Benirschke
Cold Spring Harbor Laboratory  

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New edition of a classic molecular biology textbook from CSHL Press and Benjamin Cummings
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