Navigation Links
New drug target can break down cancer's barrier against treatment
Date:7/27/2014

CANCER RESEARCH UK scientists at Barts Cancer Institute have found that targeting a molecule in blood vessels can make cancer therapy significantly more effective, according to research published in Nature today (Sunday).

The team at Barts Cancer Institute, part of Queen Mary University of London, have found that a molecule, called focal adhesion kinase (FAK), signals the body to repair itself after chemotherapy or radiotherapy, which kill cancer cells by damaging DNA. When the researchers removed FAK from blood vessels that grew in melanoma or lung cancer models, both chemotherapy and radiation therapies were far more effective in killing the tumours.

The researchers also studied samples taken from lymphoma patients. Those with low levels of FAK in their blood vessels were more likely to have complete remission following treatment. This suggests that developing drugs to strike out FAK in cancer blood vessels may boost cancer treatments and prevent cancer from coming back.

Dr Bernardo Tavora, lead author on the paper from the Barts Cancer Institute, said: "This work shows that sensitivity to cancer treatment is related to our own body mistakenly trying to shield the cancer from cell-killing effects caused by radiotherapy and chemotherapy.

"Although taking out FAK from blood vessels won't destroy the cancer by itself, it can remove the barrier cancer uses to protect itself from treatment."

Cells lining the blood vessels send chemical signals, called cytokines, to the tumour to help it resist DNA damage and to recover. The researchers demonstrated that this process requires FAK in order to work, and without it, these signals are never sent making the tumour more vulnerable to DNA damaging therapy.

Dr Kat Arney, Cancer Research UK's science communications manager, said: "This exciting research may have cracked how healthy cells in the blood vessels are protecting against cancer treatments. This research was only done in mice, but it gives real hope that we can boost the effectiveness of cancer medicine and sensitise cancers to the drugs we have."


'/>"/>

Contact: Greg Jones
greg.jones@cancer.org.uk
44-203-469-8311
Cancer Research UK
Source:Eurekalert

Related biology news :

1. Albert Einstein College of Medicine receives grant from the Michael J. Fox Foundation to fund drug discovery project targeting Parkinsons
2. Potential new flu drugs target immune response, not virus
3. Yale researchers identify targets for immunotherapy in early-stage breast cancer
4. Putting a price tag on the 2° climate target
5. Capturing CO2 emissions needed to meet climate targets
6. Pew and the Stewart Trust launch scholars program targeting cancer
7. New driver of atherosclerosis offers potential as therapeutic target
8. Criminal profiling technique targets killer diseases
9. RNA aptamers targeted to plasminogen activator inhibitor
10. Low dose of targeted drug might improve cancer-killing virus therapy
11. Subseafloor bacteria survive by over-activating DNA-repair and antibiotic target genes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/9/2016)... 2016 Nigeria . ... than 23,000 public service employees either did not exist ... salary unlawfully.    --> Nigeria ... more than 23,000 public service employees either did not ... their salary unlawfully.    --> DERMALOG, the ...
(Date:3/8/2016)... , March 8, 2016   Valencell , ... today announced it has secured $11M in Series ... Tech, a new venture fund being launched by ... participation from existing investors TDF Ventures and WSJ ... to continue its triple-digit growth and accelerate its ...
(Date:3/3/2016)... 2016  2016FLEX, organized by FlexTech, a SEMI ... in flexible, hybrid and printed electronics. More than ... have gathered for short courses, technical session, exhibits, ... The Flex Conference celebrates its 15 th ... organizations, and universities contributing to the adoption of ...
Breaking Biology News(10 mins):
(Date:4/27/2016)... British Virgin Islands (PRWEB) , ... April 27, ... ... Holding Company Ltd. (d/b/a Biohaven) is pleased to announce the appointment of John Tilton ... he was an Executive Director and one of the founding commercial leaders responsible ...
(Date:4/27/2016)... (PRWEB) , ... April 27, 2016 , ... Global ... the GSCG Advisory Board. Ross is the founder of GSCG affiliate Kimera Labs in ... Miami, where he studied hematopoietic stem cell transplantation for hematologic disorders and the suppression ...
(Date:4/26/2016)... (PRWEB) , ... April 27, 2016 , ... ... of Lewis Roca Rothgerber Christie LLP as an associate in the firm’s Intellectual ... and international electrical, mechanical and electromechanical patent applications. He has an electrical engineering ...
(Date:4/26/2016)... Francisco, CA (PRWEB) , ... April 26, 2016 , ... ... division for Adecco RPO, signing the first multi-million dollar, multi-year managed services contract in ... delighted to have Michael join our leadership team,” said John Younger, founder of Accolo. ...
Breaking Biology Technology: