Navigation Links
New drug shows promise in treating drug-resistant prostate cancer
Date:4/10/2009

A new therapy for metastatic prostate cancer has shown considerable promise in early clinical trials involving patients whose disease has become resistant to current drugs.

Chemists and biologists at UCLA and colleagues at several other institutions, including Memorial Sloan-Kettering Cancer Center, have created a new drug to treat a particularly lethal form of the disease, known as castration-resistant prostate cancer, or CRPC. Also referred to as hormone-refractory prostate cancer, CRPC is resistant to further treatment by anti-hormone drugs such as Casodex and Eulexin.

In an article published April 9 in the advanced online edition of the journal Science, the scientists describe the development and testing of two novel compounds, MDV3100 and RD162, which block the androgen receptor (AR) in CRPC cells, and report results from clinical trials in which MDV3100 was found to lower prostate-specific antigen (PSA) levels a marker for tumor growth in men with CRPC.

The new, small organic molecule MDV3100 was "designed as a very strong antagonist of the androgen receptor to stop the growth of any prostate cancer that requires the AR for propagation, which includes most forms of prostate cancer," said Michael Jung, UCLA professor of chemistry and biochemistry and a researcher at UCLA's Jonsson Comprehensive Cancer Center, whose research group synthesized both MDV3100 and RD162.

The biology research was carried out in the UCLA departments of medicine, urology and pharmacology by Charles Sawyers and his research group; Sawyers has since moved to Memorial Sloan-Kettering Cancer Center in New York, where he serves as chair of the human oncology and pathogenesis program. The UCLA patents for both compounds were licensed by the pharmaceutical company Medivation Inc., which chose to test MDV3100 in clinical trials.

The drug has successfully completed Phase 1 and Phase 2 clinical trials, and the Food and Drug Ad
'/>"/>

Contact: Stuart Wolpert
swolpert@support.ucla.edu
310-206-0511
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Research shows skeleton to be endocrine organ
2. Clones on task serve greater good, evolutionary study shows
3. Study shows link between alcohol consumption and hiv disease progression
4. Novel 3-D cell culture model shows selective tumor uptake of nanoparticles
5. New study shows greenback cutthroat trout involved in recovery effort misidentified
6. DNA analysis shows true dispersal of protozoa
7. New genetic research into nicotine addiction shows promise for personalized treatment
8. International team shows mercury concentrations in fish respond quickly to increased deposition
9. New study shows fish respond quickly to changes in mercury deposition
10. Amazon forest shows unexpected resiliency during drought
11. New study shows fish respond quickly to changes in mercury deposition
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2015)... BURNABY, Canada , August 31, 2015 ... use of biometrics technology in government digitization projects to drive ... According to a recently published TechSci Research report, " India ... India is projected to grow at ... in the market is anticipated on account of extensive use ...
(Date:8/25/2015)... LAKE CITY and BELLEVUE, Wash. ... global leader in advanced robotic systems, announced today it ... robotic unmanned ground vehicle (UGV), at the National Tactical ... City.  The Guardian S is the ... the culmination of years of research and in-field trials ...
(Date:8/20/2015)... Aug. 20, 2015   Sensory, Inc ., ... the user experience and security of consumer electronics ... announced that its TrulySecure™ is the ... to be FIDO Certified™. The FIDO ... with the FIDO UAF (Universal Authentication Framework) 1.0 ...
Breaking Biology News(10 mins):India Biometrics Market to Grow at Over 35% Through 2020, Says TechSci Research 2India Biometrics Market to Grow at Over 35% Through 2020, Says TechSci Research 3Sarcos to Debut First-of-its-Kind Snake Robot 2Sarcos to Debut First-of-its-Kind Snake Robot 3TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 2TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 3TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 4TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 5
... , Can an abundance of sea otters help reverse a principal cause ... Cruz researchers suggest that a thriving sea otter population that keeps sea ... spreading kelp can absorb as much as 12 times the amount of ... ravenous sea urchins, the study finds. The theory is ...
... Carolina State University shows that exposure to the chemical bisphenol ... anxiety by causing significant gene expression changes in a specific ... found that a soy-rich diet can mitigate these effects. ... of species, and wanted to begin to understand why and ...
... Strathclyde spin-out company has been awarded 1.4 million to ... grant towards the total cost of building and testing ... of Machrihanish, Argyll, Scotland., The award was part of ... Deputy First Minister Nicola Sturgeon, aimed at helping Scottish ...
Cached Biology News:UC Santa Cruz study shows how sea otters can reduce CO2 in the atmosphere 2Study finds how BPA affects gene expression, anxiety; Soy mitigates effects 2University spin-out company shares in £7.9 million marine energy funding boost 2
(Date:9/1/2015)... ... 01, 2015 , ... VetStem Biopharma announces new Clinical Research ... problems can be caused by injuries and abnormalities of the cervical spine. Arthritic ... of the spinal cord itself. This can manifest itself as any or all ...
(Date:9/1/2015)... ... 2015 , ... Leading CEOs, CSOs, CMOs, and heads of ... prominent academics and key investors for Neuro Advance Boston, October 14, 2015 at ... , Neuro Advance Boston focuses on the latest developments and opportunities in neuroscience ...
(Date:9/1/2015)... N.C. , Sept. 1, 2015   ... to facilitating the relationship between doctors and patients, ... Durham, N.C. -based venture capital ... strength and business association with Bull City Venture ... Malik , Medfusion Founder and Executive Chairman. "Both ...
(Date:9/1/2015)... ... September 01, 2015 , ... A new host-based therapy ... at the Keck Graduate Institute and its collaborators. The discovery has the potential ... published online on August 27 by Scientific Reports, an open access research journal ...
Breaking Biology Technology:VetStem Biopharma Announces New Clinical Research Program for Equine Cervical Facet Joint Disease 2VetStem Biopharma Announces New Clinical Research Program for Equine Cervical Facet Joint Disease 3Neuro Advance Boston Brings Together Leading Neuroscience Experts on October 14 at Harvard Medical School 2Medfusion Secures Funding to Continue Evolution and Advance Mobile Strategy 2Medfusion Secures Funding to Continue Evolution and Advance Mobile Strategy 3Scientists Discover New Use for an Old Therapy Inhibiting Deadly Pathogens Including Ebola and Anthrax 2Scientists Discover New Use for an Old Therapy Inhibiting Deadly Pathogens Including Ebola and Anthrax 3Scientists Discover New Use for an Old Therapy Inhibiting Deadly Pathogens Including Ebola and Anthrax 4
... RNA later Tissue Collection: RNA ... Tissue and Cells. , ... processing or appropriate storage of the tissue or cell , ... followed by immediate disruption in lysis ...
... Isolation , , ... different tissues. A comparison of total RNase activities for 8 different , ... from pancreas to brain (Figure 1), which highlights the level of RNase ... , Figure 1. ...
... RNA interference, the biological mechanism ... (dsRNA) induces gene silencing by , ... revolutionizing the way researchers study gene function. For , ... expression of a particular gene in mammalian cell systems, ...
Cached Biology Technology:Stabilizing RNA in Fresh and Frozen Tissues for RNA Isolation 2Stabilizing RNA in Fresh and Frozen Tissues for RNA Isolation 3Stabilizing RNA in Fresh and Frozen Tissues for RNA Isolation 4RNase Activity in Mouse Tissue: Classification, Hierarchy, and Methods for Control 2RNase Activity in Mouse Tissue: Classification, Hierarchy, and Methods for Control 3RNAi: A How To for New Users 2RNAi: A How To for New Users 3RNAi: A How To for New Users 4RNAi: A How To for New Users 5RNAi: A How To for New Users 6RNAi: A How To for New Users 7RNAi: A How To for New Users 8RNAi: A How To for New Users 9
Vitronectin Immunogen: Purified, full length, native human protein. Storage: -20 C, Avoid Freeze/Thaw Cycles...
... Guava has made microcapillary flow cytometry accessible ... experts alike will appreciate the latest addition ... Pluseasy to use, surprising affordable, and very ... system includes such features as absolute cell ...
...
Fingerprinting II Basic software is used for analyzing fingerprint sample types (electrophoretic gels, HPLC and other chromatographic patterns, spectrophotometric and densitometric curves)....
Biology Products: