Navigation Links
New drug agent knocks out multiple enzymes in cancer pathway
Date:3/25/2009

to the use of multi-kinase inhibitors in cancer therapy.

Andrew Wang, of Academia Sinica, Taipei, and Illinois chemist Rong Cao began by producing crystallographic structures of the target enzymes and drug candidates, allowing the researchers to identify those features that would enhance the drugs' ability to bind to the enzymes. Using this and other chemical data, Illinois chemistry department research scientist Yonghui Zhang engineered new bisphosphonate compounds that bound tightly to multiple enzyme targets, but not to bone.

One of the new compounds, called BPH-715, proved to be especially potent in cell culture and effectively inhibited tumor cell growth and invasiveness.

Tadahiko Kubo, of Hiroshima University, then found that BPH-715 also killed tumor cells in mice. And Socrates Papapoulos, of Leiden University, the Netherlands, showed that the compound had a very low chemical affinity for bone.

In humans, compounds like BPH-715 and zoledronate have an added benefit in fighting cancer: They spur the proliferation of immune cells called gamma delta T-cells, which aid in killing tumor cells.

"The new drugs are about 200 times more effective than the drugs used in recent clinical trials at killing tumor cells and in activating gamma delta T-cells to kill tumor cells," Oldfield said. "They also prevent tumor progression in mice much better than do existing bisphosphonate molecules."


'/>"/>

Contact: Diana Yates
diya@illinois.edu
217-333-5802
University of Illinois at Urbana-Champaign
Source:Eurekalert  

3

GOOD

Page: 1 2

Related biology news :

1. Structure of enzyme against chemical warfare agents determined
2. Chemopreventive agents in black raspberries identified
3. MIT nanotubes sniff out cancer agents in living cells
4. Exposure to Agent Orange linked to prostate cancer in Vietnam veterans
5. Certain anticancer agents could be harmful to patients with heart disease
6. UF researchers develop improved gene therapy agent
7. New insights into the diversity of Creutzfeldt-Jakob disease agents
8. Drug aimed at 2 bioterror agents blocks live viral infection, Weill Cornell team reports
9. Contrast agent trials in swine
10. Agent that triggers immune response in plants is uncovered
11. Primate behavior explained by computer agents
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New drug agent knocks out multiple enzymes in cancer pathway
(Date:5/16/2013)... lining the body,s blood vessels, is extremely resilient. ... this super-tenuous structure routinely withstands blood flow, hydrostatic ... unique and highly dynamic barrier that maintains the ... circulatory system. , It,s also extremely adaptable. In ... to enable immune cells to reach various ...
(Date:5/16/2013)... choose to wear the color red when they compete? ... Science , a journal of the Association for Psychological ... their testosterone levels. , The new study, conducted by ... and colleagues, demonstrated that males who chose red as ... levels than other males who chose blue. , "The ...
(Date:5/16/2013)... has discovered an ancient extinct creature with ,scissor hand-like, ... honour of his favourite movie star. , The ... (pronounced Koo-ten-ee-che-la depp-eye), which is a distant ancestor ... Johnny Depp for his starring role as Edward Scissorhands ... an unfinished creation, who has scissors for hands. ...
Breaking Biology News(10 mins):Endothelium, heal thyself 2Endothelium, heal thyself 3Endothelium, heal thyself 4High-testosterone competitors more likely to choose red 2Actor Johnny Depp immortalized in ancient fossil find 2
... , NEW YORK (March 23, 2011)The job of promoting conservation ... the birds, according to the authors of a new bird ... and Editora Horizonte in Sao Paulo, Brazil., Published in Portuguese ... Central Brazil" highlights the bird life of one of the ...
... We all know the adage: A little bit of a ... are reporting that might also be true for a large protein ... Kennedy Institute of Rheumatology at Imperial College reports in the ... body is under stress, such as in cases of physical trauma ...
... When the Human Genome Project ended a decade ago, ... to be known about our genes. But what they really ... Prof. Eva Jablonka of Tel Aviv University,s Cohn Institute for ... sifting through hundreds of scientific studies concerned with epigenetics, Prof. ...
Cached Biology News:WCS releases 'Birds of Brazil' 2WCS releases 'Birds of Brazil' 3Molecular muscle: Small parts of a big protein play key roles in building tissues 2Molecular muscle: Small parts of a big protein play key roles in building tissues 3Traumatizing your DNA 2
(Date:5/17/2013)... PARK, N.C., USA (PRWEB) May 17, 2013 ...     Green Globes Certified for sustainability ,     New ... insect pressures , Syngenta unveiled ... celebration today at the company’s RTP Innovation Center. The ... allows company researchers to simulate any agricultural climate and ...
(Date:5/17/2013)...  Yongye International, Inc. (NASDAQ: YONG ) ... distributor of crop nutrient products in the ... on May 16, 2013, the special committee (the "Special ... Directors") was provided a letter (the "Letter") issued by ... Limited ("Abax") to Full Alliance International Limited ("Full Alliance"). ...
(Date:5/17/2013)... 17, 2013 Men’s skin is biologically different ... Posay ) and has been known to react more aggressively ... may be far from puberty, other acne causing factors like ... breakouts, and threatening skin with unsightly acne scars. Adult acne ... Men’s Health on how to reduce and prevent acne ...
(Date:5/17/2013)... Rust removal is one of home maintenance's essential processes. ... damaged. To help rust contractors make it less expensive, My ... remover it called Rusterizer. It announced that for this ... My Cleaning Products explained that rust could damage items in ... The first one, it said, happens when rust forms ...
Breaking Biology Technology:Syngenta Opens Unique $72 Million Advanced Crop Lab 2Syngenta Opens Unique $72 Million Advanced Crop Lab 3Yongye International Provides Update on Status of Proposed Go Private Offer 2Yongye International Provides Update on Status of Proposed Go Private Offer 3Yongye International Provides Update on Status of Proposed Go Private Offer 4Adult Acne Treatment, Probiotic Action Shares New Insight on Why Men’s Skin Scars from Acne and How to Prevent It 2Organic-Based Rust Remover Cuts Down Price by 10%, My Cleaning Products Details Mechanics How to Get the Discount 2
... , QUEBEC CITY , Jan. 22 ... TSX: AEZ) (the "Company"), a late-stage drug development company specialized ... 21, 2010 , the Company received a letter from the ... the minimum closing bid price of its common shares had ...
... , ... Bioamber,( http://www.bio-amber.com/ ) , a joint venture between US-based DNP,( ... )(Agro-industrie Recherches et Développements),announces the successful start-up and commissioning of ... , the plant has been,producing renewable succinic acid from wheat ...
... ... contouring, will be presented at the upcoming ICAD & 3rd ECAA Asia conference. Dr. ... Y. Yu will present his latest clinical data showing successful reduction of acne using TriPollar. ... (PRWEB) January 20, ...
Cached Biology Technology:Æterna Zentaris Receives NASDAQ Notification Related to Minimum Bid Price 2Æterna Zentaris Receives NASDAQ Notification Related to Minimum Bid Price 3Bioamber Commissions World's First Renewable Succinic Acid Plant 2Bioamber Commissions World's First Renewable Succinic Acid Plant 3TriPollar Technology Clinically Proven to Significantly Reduce Stretch Marks and Acne 2TriPollar Technology Clinically Proven to Significantly Reduce Stretch Marks and Acne 3
Form: Ready to use Applications: Immunohistology-frozen, Immunohistology-paraffin, Western Blot, ELISA...
... H): 17 3/4" x 8 ... Programmable 0 - 100 hoursControl: Programmable 30 ... 40 user programmable protocols 3 operating modes ... temperature ramp-up from 37 - 95C and ...
Goat polyclonal to p27 KIP 1 ( Abpromise for all tested applications). Antigen: Synthetic peptide: C-KRPATDDS STQNK, corresponding to Internal sequence amino acids 153-165 of Human p27 KIP 1 ...
Anti-Mouse Macrophages (Metallophillic), Purified (Clone MOMA-1) (rat IgG2a)...
Biology Products: