Navigation Links
New disease-to-drug genetic matching puts snowboarder back on slopes
Date:6/5/2013

s fellowship training at Stanford University, and through his work there developed a relationship with researchers at the University of Oregon, which had an ongoing project in blood cancers that defied common classifications. Pollyea and his team took a sample from his patient and sent it to Oregon for testing, with the hopes that if they could identify a gene mutation causing this cancer, there might be a chance they could target the mutation with an existing drug.

Sure enough, sequencing showed a mutation in a gene that makes a protein called colony-stimulating factor 3 (CSF3R). Cells with this mutation have uncontrolled growth in the bone marrow, resulting in a leukemia.

Further studies revealed a drug, ruxolitinib, could effectively target cells with this mutation. Approved to treat another condition, myelofibrosis, just months before, the drug hadn't previously been considered as a treatment for this type of leukemia. But with dwindling options, Pollyea and colleagues decided ruxolitinib was worth a try.

"There were no good alternatives other than to use the ruxolitinib," Pollyea says. "Our patient became the first person with this condition who received this treatment. His white blood count came down, his other blood counts normalized, and his symptoms virtually disappeared."

"I had my best snowboarding season ever," says the patient. "Good, late season snow here in Colorado. Actually, I'd lived elsewhere and when I first got the disease I wondered if maybe something about moving to Colorado made it happen you know, the altitude, the lack of oxygen. But now after working with Dr. Pollyea, I realize that I didn't get sick because I live here, I got cured because I live here. Would I have had this kind of treatment anywhere else? I'm not so sure."

Both patient and doctor are clear that "cure" is an imprecise word to use in this case, but so far improvement seems durable. This experience will now serve as the basis of a plann
'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Epigenetic biomarkers may predict if a specific diet and exercise regimen will work
2. Genetic engineering alters mosquitoes sense of smell
3. U of A medical researchers ID genetic marker for sporadic breast cancer
4. Family studies suggest rare genetic mutations team up to cause schizophrenia
5. Fast new, 1-step genetic engineering technology
6. Genetic predictors of postpartum depression uncovered by Hopkins researchers
7. Genetic risk for schizophrenia is connected to reduced IQ
8. European Society of Human Genetics urges caution over use of new genetic sequencing techniques
9. University of Maryland Medical Center launches genetic-testing program for cardiac patients
10. Penn Medicine researchers identify 4 new genetic risk factors for testicular cancer
11. Fred Hutch evolutionary geneticist Harmit Malik selected as an HHMI investigator
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... An Australian National University (ANU) team has successfully replicated ... way for biological systems powered by sunlight which could ... and so is sunlight. It is an exciting prospect ... cheaply and safely," said Dr Kastoori Hingorani, from the ... ANU Research School of Biology. , Hydrogen offers potential ...
(Date:8/20/2014)... SALT LAKE CITY Researchers at Huntsman Cancer Institute (HCI) ... mutated forms of the gene that encodes BCR-ABL, the ... (CML). According to the American Cancer Society, nearly 6,000 ... , Drugs already in use, called tyrosine kinase inhibitors ... disease. They do not cure CML but control it ...
(Date:8/20/2014)... of approximately 3 million infants, a team of scientists ... of Massachusetts Medical School, have shown that newborn screening ... across public health newborn screening programs. Data from 11 ... of the Journal of the American Medical Association ... in newborns is higher than previously thought and believed ...
Breaking Biology News(10 mins):Water and sunlight the formula for sustainable fuel 2Blueprint for next generation of chronic myeloid leukemia treatment 2Newborn screening expansion offers early diagnosis and treatment to infants with SCID 2Newborn screening expansion offers early diagnosis and treatment to infants with SCID 3
... only sends the human immune system into overdrive it ... work and thrive inside our digestive system. New research ... a significant role in triggering the innate immune system to ... action in the face of an infection. But exactly ...
... (April 11, 2011) Periodontal ligament stem ... efficacious of three kinds of clinically tested dental tissue-derived ... issue of Cell Transplantation (20:2), freely available ... Seoul, South Korea, transplantation of PDLSCs into beagle dogs ...
... Radiation Research Institute (JASRI) have cut the ribbon on ... in Harima, the first such facility in Japan and ... (SPring-8 Angstrom Compact Free Electron Laser), the new XFEL,s ... minuscule structure of molecules and rapid reaction of chemical ...
Cached Biology News:Stress wrecks intestinal bacteria, could keep immune system on idle 2Periodontal stem cell transplantation shows promise 2RIKEN and JASRI unveil 'SACLA', Japan's first X-ray free electron laser 2
(Date:8/20/2014)... International Corporation (NASDAQ: PRXL ) announced today ... Conference in New York.  Ingo Bank , Senior ... a presentation on PAREXEL and discussing business developments at ... A live webcast of the discussion will be ... www.PAREXEL.com in the Upcoming Events portion of ...
(Date:8/20/2014)... JOSE, Calif. , Aug. 20, 2014 /PRNewswire-iReach/ ... highlights the transformative collaboration between the school,s bioengineering ... As part of the Intel® Software Academic Program, ... computer sciences and the human body.  ... The study exhibits the work of Dr. ...
(Date:8/20/2014)... Sofia, Bulgaria (PRWEB) August 20, 2014 ... was released today including improvements to the ... rates and connectors for Lucene, SOLR and Elasticsearch. ... change for this high performance triplestore – GraphDB™ ... organizations interested in deploying the only mature enterprise ...
(Date:8/19/2014)... Research and Markets  has announced the addition of ... Report" report to their offering. This report ... US$ Thousands by the following Product Segments: Media, Sera, and Reagents. ... Canada , Japan , ... Latin America . Annual estimates and forecasts are provided ...
Breaking Biology Technology:PAREXEL International To Present At Baird Healthcare Conference 2Intel and University of San Diego Bioengineering Department Release Case Study on Health Sciences Research 2Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 2Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 3Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 4Global Cell and Tissue Culture Supplies - Strategic Business Report 2014 2
... first thing to do when draining a swamp is to ... an information swamp. Information not only needs to be better ... as its passed within an organization. IT shops are skilled ... and even the old, back office systems running on mainframes. ...
... Wis. Metavante Corporation , a Milwaukee-based provider ... Opsware System to automate its data center operations Tuesday. ... the tasks associated with managing its multi-data center information ... automation software has the opportunity to reduce complexity and ...
... make RFID an integral part of business and Wisconsin companies ... (radio frequency identification) tags and labels are small programmable carriers of ... an item. Also known as Smart Tags and Smart Labels, they ... Unlike bar codes, RFID tags and labels dont need to be ...
Cached Biology Technology:Draining the Information Swamp 2Draining the Information Swamp 3Bar Codes Have a New Best Friend RFID 2Bar Codes Have a New Best Friend RFID 3
PTFE/red rubber septum silver aluminum seal ,11 mm seal diam. ...
...
... an enzyme that catalyzes the hydrolysis ... maltotriose, and dextrins. The,level of a-amylase ... body is of,clinical significance in the ... diabetes; plant and microbial a-amylases are,important ...
... The Jouan MSC series of Class ... working conditions and certification to the ... regulation ensures that the cabinets cannot ... conditions. Natural lighting, low noise and ...
Biology Products: