Navigation Links
New discovery suggests our lungs are 'innately prone' to silicosis and related diseases
Date:8/31/2010

For the nearly 2 million U.S. workers exposed to silica dust each year, a new discovery may help prevent or treat the development of chronic lung diseases related to this exposure. In the September 2010 issue of the Journal of Leukocyte Biology (http://www.jleukbio.org) scientists from Montana and Texas use mice to show for the first time that the part of our immune system responsible for keeping airways clean and free of contaminants (innate immunity) can cause inflammation and symptoms of disease. This study is significant because it is generally believed that reducing chronic inflammation will improve the quality of life for patients.

"Some of the most difficult lung diseases to treat are those that involve chronic inflammation and exposure to harmful particulates," said Celine A. Beamer, Ph.D., a researcher from University of Montana, Center for Environmental Health Sciences who was involved in the work. "Hopefully, the information from this study will move us a step closer to curbing dangerous airway and lung inflammation."

To make this discovery, scientists treated two groups of mice with silica, a common mineral often found in sand or quartz, and then measured for the development of silicosis. The first group consisted of normal mice with a normal immune system, while the second group included mice with an inactive adaptive immune system. The normal mice developed silicosis as expected, but the disease was even more prevalent in the mice without the adaptive immune system. Silicosis is a chronic lung disease caused by breathing in dust containing silica, often setting the stage for tuberculosis.

"The lungs are very complex and delicate organs, and many different kinds of chronic inflammation in the respiratory tract can lead to difficulty with normal daily activities," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "For many people, chronic i
'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. A plan to promote sustainable US scientific discovery and innovation in the 21st century is proposed in OMICS
2. Discovery opens door to therapeutic development for FSH muscular dystrophy
3. Possible discovery of earliest animal life pushes back fossil record
4. Discovery of possible earliest animal life pushes back fossil record
5. Huntingtons disease discovery provides new hope for treatment
6. Rediscovery: MBL scientists confirm role for mysterious cell component, the nucleolinus
7. Discovery points to new approach for diabetes therapy
8. DNA discovery opens new door to develop tools, therapies for hereditary cancers
9. Discovery of a hepatitis C-related virus in bats may reduce outbreaks in humans
10. Discovery of how coral reefs adapt to global warming could aid reef restoration
11. Discovery of controlled swarm in bacteria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)...   LaunchKey , the first decentralized mobile authentication ... of Things era, today announced the close of $3 ... led by Metamorphic Ventures with participation from ENIAC Ventures, ... others.  LaunchKey has raised $4 million to date, and ... and bring LaunchKey to market in 2015. ...
(Date:12/17/2014)... Valencell, a leader in performance biometric data ... industry leaders such as Intel, Jabra, Atlas, and Scosche ... products. These products will be showcased at CES 2015, ... . "Our partners choose PerformTek ... – with the clinical data to back it up," ...
(Date:12/11/2014)... --Research and Markets , ... ) has announced the addition of the ... to their offering. One major ... technology. With continuous advances in technology, it is ... standard that meets the needs and expectations of ...
Breaking Biology News(10 mins):LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... release is available in French . ... action to better control the sale of chemicals that ... Lunn, Minister of Natural Resources, and the Honourable Stockwell ... regulations for these chemicals, known as explosives precursors, will ...
... American,Association of Airport Executives President Chip ... Traveler (RT) program with the opening of,RT ... Reagan,Washington National Airport., "The expansion of ... in,the nation,s capital will further highlight the ...
... — Robots are fluent in their native language of 1 ... imprecise nature of human language. While scientists are making slow, ... responds to speech, gestures and body language, a more straightforward ... homes sooner. A team of researchers led by Charlie ...
Cached Biology News:New regulations tighten controls on restricted chemicals 2AAAE Applauds Expansion of Registered Traveler Program to Nation's Capital 2AAAE Applauds Expansion of Registered Traveler Program to Nation's Capital 3Robot fetches objects with just a point and a click 2Robot fetches objects with just a point and a click 3Robot fetches objects with just a point and a click 4
(Date:12/22/2014)... 22, 2014 The American ... of original research, reviews and editorials addressing developments ... practice, today published a provocative article exploring the ... progression and potential treatment of prostate cancer. ... and proposes the possibility that there could be ...
(Date:12/22/2014)... 2014 Fertility Associates of Memphis has ... USA , a network of more than 20 contributing ... patients have fast access to a national pool of ... . Fertility Associates of Memphis is the only fertility ... option. , Dr. William Kutteh , director of ...
(Date:12/19/2014)... Charm Sciences is pleased to announce that ... Aflatoxin M1 in raw commingled milk is the first ... The peer reviewed report of the validation by Technology ... and Fisheries Research (ILVO-T&V) has been published by the ... most toxic aflatoxin and a known carcinogen, can be ...
(Date:12/19/2014)... 19, 2014 Naurex Inc., a biopharmaceutical company ... diseases of the central nervous system, today announced that ... officer, will present at the 33 rd annual ... place at 3:00 p.m. PST on Tuesday, January 13, ... San Francisco, Calif. About ...
Breaking Biology Technology:Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 2Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 3Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 4Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3Charm Sciences Achieves Independent Validation of First 15 Minute Quantitative Screening Method for Aflatoxin M1 2Naurex to Present at 33rd Annual J.P. Morgan Healthcare Conference 2
... , , BETHESDA, Md., July ... and NWBS) today announces that it will seek shareholder approval for ... AIM market ("AIM") (the "De-listing"). The Company plans to continue its ... Board Market ("U.S. listing"), and plans to file an S1 registration ...
... , SAN DIEGO, July 23 Anadys Pharmaceuticals, Inc. ... quarter 2009 financial results on Thursday, July 30, 2009, after the U.S. ... hold a conference call and webcast on Thursday, July 30, 2009 at ... results and highlights and to provide an update on its development programs. ...
... , SUNNYVALE, Calif., July 23 ... for the treatment of chronic total occlusions (CTOs), today announced the ... Chris previously held the position of Executive VP, Sales and Marketing ... Devices including the last 2 years at FlowCardia. , ...
Cached Biology Technology:Northwest Biotherapeutics Announces Plans to De-list From AIM and Consolidate its Stock Market Listing in U.S. 2Northwest Biotherapeutics Announces Plans to De-list From AIM and Consolidate its Stock Market Listing in U.S. 3Anadys Pharmaceuticals to Report Second Quarter 2009 Financial Results 2FlowCardia, Inc. Appoints Chris Barys to Chief Operating Officer 2
...
Request Info...
OmniSlide thermal Cycler for slide applications. 20 slide capacity. Humidity Chamber. Slide Rack can be transferred directly to Wash Module to avoid handling individual slides....
... effect inhibition assays, also known as CPE and ... supernatents; serum from PK studies and delivery formulations. ... as the quantity of interferon required per milliliter ... by 50%. All standards used in ...
Biology Products: