Navigation Links
New discovery suggests our lungs are 'innately prone' to silicosis and related diseases
Date:8/31/2010

For the nearly 2 million U.S. workers exposed to silica dust each year, a new discovery may help prevent or treat the development of chronic lung diseases related to this exposure. In the September 2010 issue of the Journal of Leukocyte Biology (http://www.jleukbio.org) scientists from Montana and Texas use mice to show for the first time that the part of our immune system responsible for keeping airways clean and free of contaminants (innate immunity) can cause inflammation and symptoms of disease. This study is significant because it is generally believed that reducing chronic inflammation will improve the quality of life for patients.

"Some of the most difficult lung diseases to treat are those that involve chronic inflammation and exposure to harmful particulates," said Celine A. Beamer, Ph.D., a researcher from University of Montana, Center for Environmental Health Sciences who was involved in the work. "Hopefully, the information from this study will move us a step closer to curbing dangerous airway and lung inflammation."

To make this discovery, scientists treated two groups of mice with silica, a common mineral often found in sand or quartz, and then measured for the development of silicosis. The first group consisted of normal mice with a normal immune system, while the second group included mice with an inactive adaptive immune system. The normal mice developed silicosis as expected, but the disease was even more prevalent in the mice without the adaptive immune system. Silicosis is a chronic lung disease caused by breathing in dust containing silica, often setting the stage for tuberculosis.

"The lungs are very complex and delicate organs, and many different kinds of chronic inflammation in the respiratory tract can lead to difficulty with normal daily activities," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "For many people, chronic inflammation is a problem that leads to the destruction of this tissue. This study gives us a much better understanding of how this inflammation occurs, and as a result, new avenues for stopping it."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. A plan to promote sustainable US scientific discovery and innovation in the 21st century is proposed in OMICS
2. Discovery opens door to therapeutic development for FSH muscular dystrophy
3. Possible discovery of earliest animal life pushes back fossil record
4. Discovery of possible earliest animal life pushes back fossil record
5. Huntingtons disease discovery provides new hope for treatment
6. Rediscovery: MBL scientists confirm role for mysterious cell component, the nucleolinus
7. Discovery points to new approach for diabetes therapy
8. DNA discovery opens new door to develop tools, therapies for hereditary cancers
9. Discovery of a hepatitis C-related virus in bats may reduce outbreaks in humans
10. Discovery of how coral reefs adapt to global warming could aid reef restoration
11. Discovery of controlled swarm in bacteria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/20/2017)... (NYSE: DAL ) customers now can use fingerprints instead of ... Airport (DCA). ... Delta launches biometrics to board aircraft at Reagan Washington National Airport ... Delta,s biometric boarding pass experience that launched in May ... boarding process to allow eligible Delta SkyMiles Members who are enrolled in ...
(Date:5/16/2017)... 16, 2017  Veratad Technologies, LLC ( www.veratad.com ), ... and identity verification solutions, announced today they will participate ... May 15 thru May 17, 2017, in ... Trade Center. Identity impacts the lives ... today,s quickly evolving digital world, defining identity is critical ...
(Date:4/18/2017)... Inc., a global expert in SoC-based imaging and computing solutions, has ... features the company,s hybrid codec technology. A demonstration utilizing TeraFaces ® ... be showcased during the upcoming Medtec Japan at Tokyo Big Sight ... Las Vegas Convention Center April 24-27. ... Click here for an image of the ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... Surgical Wound Market with the addition of its newest module, US Hemostats & ... market for thrombin hemostats, absorbable hemostats, fibrin sealants, synthetic sealants and biologic sealants ...
(Date:10/11/2017)... YORBA LINDA, CA (PRWEB) , ... October 11, ... ... adapted to upregulate any gene in its endogenous context, enabling overexpression experiments and ... activation (CRISPRa) system with small RNA guides is transformative for performing systematic gain-of-function ...
(Date:10/11/2017)... 2017  VMS BioMarketing, a leading provider of patient support ... Nurse Educator (CNE) network, which will launch this week. The ... health care professionals to enhance the patient care experience by ... other health care professionals to help women who have been ... ...
(Date:10/11/2017)... ... October 11, 2017 , ... Singh Biotechnology ... drug designation to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator of Transcription ... is able to cross the cell membrane and bind intracellular STAT3 and inhibit ...
Breaking Biology Technology: