Navigation Links
New discovery suggests our lungs are 'innately prone' to silicosis and related diseases
Date:8/31/2010

For the nearly 2 million U.S. workers exposed to silica dust each year, a new discovery may help prevent or treat the development of chronic lung diseases related to this exposure. In the September 2010 issue of the Journal of Leukocyte Biology (http://www.jleukbio.org) scientists from Montana and Texas use mice to show for the first time that the part of our immune system responsible for keeping airways clean and free of contaminants (innate immunity) can cause inflammation and symptoms of disease. This study is significant because it is generally believed that reducing chronic inflammation will improve the quality of life for patients.

"Some of the most difficult lung diseases to treat are those that involve chronic inflammation and exposure to harmful particulates," said Celine A. Beamer, Ph.D., a researcher from University of Montana, Center for Environmental Health Sciences who was involved in the work. "Hopefully, the information from this study will move us a step closer to curbing dangerous airway and lung inflammation."

To make this discovery, scientists treated two groups of mice with silica, a common mineral often found in sand or quartz, and then measured for the development of silicosis. The first group consisted of normal mice with a normal immune system, while the second group included mice with an inactive adaptive immune system. The normal mice developed silicosis as expected, but the disease was even more prevalent in the mice without the adaptive immune system. Silicosis is a chronic lung disease caused by breathing in dust containing silica, often setting the stage for tuberculosis.

"The lungs are very complex and delicate organs, and many different kinds of chronic inflammation in the respiratory tract can lead to difficulty with normal daily activities," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "For many people, chronic inflammation is a problem that leads to the destruction of this tissue. This study gives us a much better understanding of how this inflammation occurs, and as a result, new avenues for stopping it."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. A plan to promote sustainable US scientific discovery and innovation in the 21st century is proposed in OMICS
2. Discovery opens door to therapeutic development for FSH muscular dystrophy
3. Possible discovery of earliest animal life pushes back fossil record
4. Discovery of possible earliest animal life pushes back fossil record
5. Huntingtons disease discovery provides new hope for treatment
6. Rediscovery: MBL scientists confirm role for mysterious cell component, the nucleolinus
7. Discovery points to new approach for diabetes therapy
8. DNA discovery opens new door to develop tools, therapies for hereditary cancers
9. Discovery of a hepatitis C-related virus in bats may reduce outbreaks in humans
10. Discovery of how coral reefs adapt to global warming could aid reef restoration
11. Discovery of controlled swarm in bacteria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/3/2016)... LONDON , June 3, 2016 /PRNewswire/ ... Transport Management) von Nepal ... ,Angebot und Lieferung hochsicherer geprägter Kennzeichen, einschließlich ... weltweit führend in der Produktion und Implementierung ... an der Ausschreibung im Januar teilgenommen, aber ...
(Date:6/1/2016)... , June 1, 2016 Favorable ... Election Administration and Criminal Identification to Boost Global Biometrics ... recently released TechSci Research report, " Global Biometrics Market ... Competition Forecast and Opportunities, 2011 - 2021", the global ... by 2021, on account of growing security concerns across ...
(Date:5/12/2016)... 2016 WearablesResearch.com , a brand of ... results from the Q1 wave of its quarterly wearables ... consumers, receptivity to a program where they would receive ... insurance company. "We were surprised to see ... Michael LaColla , CEO of Troubadour Research, "primarily because ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... -- The Prostate Cancer Foundation (PCF) is pleased to announce 24 new ... prostate cancer. Members of the Class of 2016 were selected from a pool ... Read More About the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... ... June 23, 2016 , ... STACS DNA Inc., the sample tracking software company, ... Crime Laboratory, has joined STACS DNA as a Field Application Specialist. , “I ... President and COO of STACS DNA. “In further expanding our capacity as a scientific ...
(Date:6/23/2016)... -- Andrew D Zelenetz , ... Published recently in Oncology & ... Andrew D Zelenetz , discusses the fact ... placing an increasing burden on healthcare systems worldwide, ... the patents on many biologics expiring, interest in ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... a new line of intelligent tools designed, tuned and optimized exclusively for Okuma ... 12–17 in Chicago. The result of a collaboration among several companies with expertise ...
Breaking Biology Technology: