Navigation Links
New discovery paves the way for new diagnosis of serious lung disease
Date:3/2/2009

The discovery by Uppsala University researchers of a previously unknown protein in the cells of the lower air ways brings new potential for early diagnosis of a serious lung disease. The findings, published today in the Web edition of the American journal Proceedings of the National Academy of Sciences, can also provide new knowledge of the cause of common diseases like asthma and chronic bronchitis.

Researchers at Uppsala University and Uppsala University Hospital have identified a protein in the lungs that is important to the immune defense system in an autoimmune lung disorder that is not seldom fatal. The newly discovered protein, called KCNRG, occurs in cells in the lower air ways found on the surface of the bronchia. This observation enables researchers to study more closely the first phase of the autoimmune disease, that is, when the immune system erroneously attacks the body's own tissues instead of attacking foreign organisms like bacteria or viruses. The discovery also provides new avenues for developing new diagnostic methods.

The researchers used an unusual hereditary autoimmune disorder, autoimmune polyendocrine syndrome type 1 (APS-1), as a model. Patients with this disease are afflicted by the immune system erroneously attacking several tissues, such as the liver, insulin-producing cells, and adrenal glands.

"Only now have we understood that the lungs are attacked as well and that in many cases this is the most serious component of the disease APS-1," says Dr. Mohammad Alimohammadi.

"It's our hope that the discovery of the protein that the immune system targets, besides making early diagnosis possible, will also be possible to use in understanding the mechanism behind the occurrence of common public health disorders like asthma and chronic bronchitis."


'/>"/>

Contact: Mohammad Alimohammadi
mohammad.alimohammadi@medsci.uu.se
46-070-882-9922
Uppsala University
Source:Eurekalert

Page: 1

Related biology news :

1. La Jolla Institute signs exclusive license agreement with Medimmune on major asthma discovery
2. Rett Syndrome Research Trust advisor makes significant discovery
3. Singapore research organisations team up to advance drug discovery using brain tumor stem cells
4. Breaking the barrier: Discovery of anti-resistance factors and novel ocean drugs
5. Major step for drug discovery and diagnostics
6. Cell-building discovery could reduce need for some animal research
7. New discovery may lead to new class of allergy drugs
8. Discovery could lead to a new animal model for hepatitis C
9. Billion-year revision of plant evolution timeline may stem from discovery of lignin in seaweed
10. Cancer-causing gene discovery suggests new therapies
11. Jumbo-sized discovery made in Malaysia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2016)... , Dec. 14, 2016 "Increase in ... biometrics market" The mobile biometrics market is expected to ... 49.33 billion by 2022, at a CAGR of 29.3% ... factors such as the growing demand for smart devices, ... transactions. "Software component is expected to grow ...
(Date:12/7/2016)... According to a new market research report "Emotion Detection and Recognition Market ... Application Area, End User, And Region - Global Forecast to 2021", published by ... 2016 to USD 36.07 Billion by 2021, at a Compound Annual Growth Rate ... ... MarketsandMarkets Logo ...
(Date:12/6/2016)... Dec. 6, 2016  Zimmer Biomet Holdings, Inc. (NYSE and ... an offering of €500.0 million principal amount of its 1.414% ... of its 2.425% senior unsecured notes due 2026. ... on December 13, 2016, subject to the satisfaction of customary closing ... The Company intends to use ...
Breaking Biology News(10 mins):
(Date:1/16/2017)... Jan. 16, 2017  Eurofins Genomics today announced the ... more customers to receive their primers in a shorter ... in quality found with other providers. Express oligos are ... at no additional fee. Researchers ... studies, including DNA sequencing, genotyping, site-directed mutagenesis, and cloning. ...
(Date:1/14/2017)... , Jan. 13, 2017  The Alliance for ... in response to FDA final guidance on ... its continued leadership in emphasizing the importance of distinct ... keenly aware of the benefits biosimilars will bring to ... Yet the portion of the Guidance dealing ...
(Date:1/13/2017)... , Jan 13, 2017 Research and Markets ... report to their offering. ... The global biopolymers market to grow at a CAGR of 16.83% during ... and the growth prospects of the global biopolymers market for 2017-2021. To ... sale of sales of biopolymer products. The report also includes a a ...
(Date:1/13/2017)... Island, NY (PRWEB) , ... January 13, 2017 ... ... to meet every cuvette-related demand that it has found among its diverse customer ... cuvettes for use in most brands electroporators including BTX and Bio-Rad. FireflySci ...
Breaking Biology Technology: