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New discovery on role of vital protein that fights meningitis
Date:5/6/2008

mmune system by wall components of bacteria.

In conditions relating to multi-organ dysfunction, a complication which can occur in response to severe sepsis, Properdin however aggravates organ damage.

Dr Stover added: So far, the system Properdin is a part of - the so-called complement system - is classified as a first line, innate, acutely effective immune activation mechanism.

My work shows that the activity of Properdin extends beyond the acute phase and, importantly, that Properdin is stepping onto the stage as an important player in different inflammatory conditions.

As the worldwide burden of chronic inflammatory disease increases, it is of practical relevance to understand the contribution of this immune protein.

The history of Properdin extends about 50 years with the first significant biochemical characterisations made in the USA, however, subsequently, the UK has contributed tremendously with the characterisation of the Properdin gene and structural modelling of the Properdin protein.


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Contact: Dr. Cordula Stover
01-162-522-951
University of Leicester
Source:Eurekalert

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