Navigation Links
New discovery on role of vital protein that fights meningitis
Date:5/6/2008

A University of Leicester researcher has discovered how a protein in the blood linked to defence against meningitis - plays a more vital role than previously understood in the bodys immune defence system.

The published research has helped to advance medical understanding of how the body defends against disease and heals itself.

The study also reveals that the same protein, Properdin discovered only half a century ago- can also harm internal organs under certain circumstances.

Lack of the protein in the human body has previously been linked to susceptibility to meningitis.

But the new findings by Dr Cordula Stover, of the Department of Infection, Immunity and Inflammation at the University of Leicester assign hitherto unappreciated importance to this protein of the immune defence.

Her work, funded by the Medical Research Council (MRC), is published in the form of two papers in the Journal of Immunology. It is being published in print on May 15.

Dr Stover, a Lecturer in Immunology, said: I have a broad interest in immune mechanisms of health and disease, though recently, I have focused on a particular component of the first line immune defence, a protein called Properdin.

Properdin deficiency in families, though rare, predisposes people to develop meningococcal meningitis, usually with poor outcome of the infection.

I hypothesised that the importance of Properdin extends beyond this particular infectious disease, and that indeed it is an important player in health generally, and that its importance becomes apparent in conditions involving both acute and chronic states of inflammation.

I was most delighted to obtain funding from the MRC to investigate this.

Now two of Dr Stovers papers, published in the Journal of Immunology, demonstrate that Properdin plays a significant role in the survival of conditions relating to surgical perforation of the gut and activation of the immune system by wall components of bacteria.

In conditions relating to multi-organ dysfunction, a complication which can occur in response to severe sepsis, Properdin however aggravates organ damage.

Dr Stover added: So far, the system Properdin is a part of - the so-called complement system - is classified as a first line, innate, acutely effective immune activation mechanism.

My work shows that the activity of Properdin extends beyond the acute phase and, importantly, that Properdin is stepping onto the stage as an important player in different inflammatory conditions.

As the worldwide burden of chronic inflammatory disease increases, it is of practical relevance to understand the contribution of this immune protein.

The history of Properdin extends about 50 years with the first significant biochemical characterisations made in the USA, however, subsequently, the UK has contributed tremendously with the characterisation of the Properdin gene and structural modelling of the Properdin protein.


'/>"/>

Contact: Dr. Cordula Stover
01-162-522-951
University of Leicester
Source:Eurekalert

Related biology news :

1. University of Arizona scientist shares in discovery of microbe filaments power
2. Stopping unwanted cell death: Implications for drug discovery
3. Journey to the center of the earth: Discovery sheds light on mantle formation
4. UC San Diego researchers eliminate drug discovery bottleneck
5. Work with power grids leads to cell biology discovery
6. Surprising discovery from first large-scale analysis of biodiversity and biogeography of viruses
7. International team announces discovery of massive Jurassic marine reptile
8. Gene discovery made easier with powerful new networking technique
9. Weird water: Discovery challenges long-held beliefs about waters special properties
10. UBC discovery unlocks tree genetics, gives new hope for pine beetle defense
11. Leading researchers and experts gather to discuss latest advancements in drug discovery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/12/2016)... WearablesResearch.com , a brand of Troubadour Research & ... Q1 wave of its quarterly wearables survey. A particular ... a program where they would receive discounts for sharing ... "We were surprised to see that so many ... CEO of Troubadour Research, "primarily because there are segments ...
(Date:4/26/2016)... and LONDON , April ... part of EdgeVerve Systems, a product subsidiary of ... today announced a partnership to integrate the Onegini ...      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ) ... their customers enhanced security to access and transact ...
(Date:4/14/2016)... Israel , April 14, 2016 ... Authentication and Malware Detection, today announced the appointment of ... assumed the new role. Goldwerger,s leadership appointment ... on the heels of the deployment of its platform ... BioCatch,s behavioral biometric technology, which discerns unique cognitive and ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... Diego, CA (PRWEB) , ... June 27, 2016 , ... ... solutions for clinical trials, announced today the Clinical Reach Virtual Patient Encounter ... their care circle with the physician and clinical trial team. , Using the CONSULT ...
(Date:6/27/2016)... 27, 2016  Liquid Biotech USA ... of a Sponsored Research Agreement with The University ... (CTCs) from cancer patients.  The funding will be ... correlate with clinical outcomes in cancer patients undergoing ... then be employed to support the design of ...
(Date:6/24/2016)... 24, 2016 Epic Sciences unveiled a ... susceptible to PARP inhibitors by targeting homologous recombination ... The new test has already been incorporated into ... cancer types. Over 230 clinical trials ... pathways, including PARP, ATM, ATR, DNA-PK and WEE-1. ...
(Date:6/23/2016)... ... June 23, 2016 , ... Mosio, a ... eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering with experienced clinical research ... by providing practical tips, tools, and strategies for clinical researchers. , “The landscape ...
Breaking Biology Technology: