Navigation Links
New discovery may lead to new class of allergy drugs
Date:1/29/2009

If you've ever wondered why some allergic reactions progress quickly and may even become fatal, a new research report published in the February 2009 issue of the Journal of Leukocyte Biology (http://www.jleukbio.org) provides an important part of the answer. In the report, scientists from Queen's University of Belfast, University of Oxford and Trinity College Dublin show for the first time that eotaxin, a chemical that helps immune cells locate the site of infection, blocks basic "fighter" cells from transforming into "seeker" dendritic cells, resulting in a heightened allergic response.

"Our study reveals a new role for the chemokine eotaxin in controlling immune cell types at the site of allergic reaction," said Nigel Stevenson, a researcher involved in the study. "These findings are crucial for our understanding of allergic responses and may be instrumental for the design of new allergy drugs."

Stevenson and colleagues made this discovery by using immune cells grown in the lab and from healthy volunteers. Then the researchers mimicked what occurs during an allergic reaction by treating the cells with eotaxin, which was previously believed to only attract immune cells during an allergic reaction. Through a series of laboratory procedures, they tracked changes in immune cell type and found that eotaxin inhibits monocytes becoming dendritic cells (that find foreign invaders so other immune cells can neutralize them), resulting in more "fighter" cells being present during an allergic response. This discovery shows how and why eotaxin plays an important role in the severity of allergic reactions and may be a target for an entirely new class of allergy medications.

"For some people, allergies are very serious often debilitating problem, forcing them to be extremely careful about what they breathe, touch, or eat," said E. John Wherry, Deputy Editor of the Journal of Leukocyte Biology. "The insights from this work on the unexpected role of eotaxin should provide novel therapeutic opportunities for intervention during diseases like asthma, food allergies and other situations where unchecked allergic responses cause problems."

According to the U.S. Centers for Disease Control and Prevention Allergies, more than 50 million Americans suffer from allergies each year. Allergies are the 6th leading cause of chronic illness in the U.S., costing more than $18 billion. The most severe type of allergic reaction is called "anaphylaxis," which can be fatal.


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Discovery could lead to a new animal model for hepatitis C
2. Billion-year revision of plant evolution timeline may stem from discovery of lignin in seaweed
3. Cancer-causing gene discovery suggests new therapies
4. Jumbo-sized discovery made in Malaysia
5. UC Davis discovery offers hope for treating kidney cancer
6. Life Sciences Discovery Fund awards health research program grants
7. In just 5 years, gene discovery to clinical trial of potential treatment
8. Discovery of new gene associated with diabetes risk suggests link with body clock
9. Kidney function discovery sheds light on genetic complexity of disease
10. New discovery may enhance MRI scans, lead to portable MRI machines
11. Discovery of giant roaming deep sea protist provides new perspective on animal evolution
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2016)... 2016   Acuant , the leading ... has partnered with RightCrowd ® to ... Management, Self-Service Kiosks and Continuous Workforce Assurance. ... functional enhancements to existing physical access control ... with an automated ID verification and authentication ...
(Date:6/16/2016)... The global Biometric ... USD 1.83 billion by 2024, according to a ... proliferation and increasing demand in commercial buildings, consumer ... the market growth.      (Logo: ... of advanced multimodal techniques for biometric authentication and ...
(Date:6/7/2016)... , June 7, 2016  Syngrafii Inc. ... a business relationship that includes integrating Syngrafii,s patented ... branch project. This collaboration will result in greater ... the credit union, while maintaining existing document workflow ... http://photos.prnewswire.com/prnh/20160606/375871LOGO ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Rolf ... join the faculty of the University of North Carolina Kenan-Flagler Business School ... and entrepreneurship at UNC Kenan-Flagler, with a focus on the school’s international efforts, ...
(Date:6/24/2016)... ... ... While the majority of commercial spectrophotometers and fluorometers use the z-dimension of ... higher end machines that use the more unconventional z-dimension of 20mm. Z-dimension ... of the cuvette holder. , FireflySci has developed several Agilent flow cell product ...
(Date:6/23/2016)... , June 23, 2016 /PRNewswire/ - FACIT has ... Ontario biotechnology company, Propellon Therapeutics Inc. ... and commercialization of a portfolio of first-in-class WDR5 ... targets such as WDR5 represent an exciting class ... in precision medicine for cancer patients. Substantial advances ...
(Date:6/23/2016)... 23, 2016  The Biodesign Challenge (BDC), a university ... to harness living systems and biotechnology, announced its winning ... New York City . ... showcased projects at MoMA,s Celeste Bartos Theater during the ... MoMA,s senior curator of architecture and design, and ...
Breaking Biology Technology: