Navigation Links
New discovery is a significant boost to cancer research
Date:4/4/2010

A team of scientists led by the University of East Anglia (UEA) has discovered a brand new group of molecules which could help fight the spread of cancer and other diseases.

The new molecules are synthetic derivatives of a natural product known as UDP-Galactose, and block the activity of a group of enzymes called glycosyltransferases. Glycosyltransferases are used by biological cells to turn simple sugars into elongated sugar chains and branched structures.

Published online today by the journal Nature Chemical Biology, the findings could lead to a significant therapeutic advance in the treatment of cancer, inflammation and infection.

Many biological cells - including cancer cells and bacterial cells - are literally covered by a coating of sugar. This sugar coating influences the way cells communicate with their environment and with each other.

For example, when a cancer spreads through the body or a bacterium infiltrates its human host many of the contacts the rogue cells make with other cells are through these sugars on their cell surface.

To form the complex sugar structures that decorate their surface, cells rely on gylcosyltransferases to join individual sugar building blocks together. The UEA researchers have found that synthetic UDP-Galactose derivatives block these enzymes effectively. These molecules can therefore potentially be used to interfere with harmful biological processes such as cancer metastasis and bacterial infection.

The work was carried out by researchers at UEA's School of Pharmacy, working alongside colleagues at the Carlsberg Research Centre in Denmark.

"This exciting discovery of a potent enzyme inhibitor with a completely new mechanism of action has considerable therapeutic potential in cancer, inflammation and infection," said lead author Dr Gerd Wagner of UEA.

"Our results also provide a general strategy for how to design and improve such inhibitors in the future. The 'snapshots' we have taken of one of these enzymes, together with the new inhibitor itself, can provide very valuable guidance for the development of new anti-cancer and anti-infective drug candidates."


'/>"/>

Contact: Press office
press@uea.ac.uk
44-016-035-93496
University of East Anglia
Source:Eurekalert

Related biology news :

1. Queens University professors chemistry discovery may revolutionize cooking oil production
2. Discovery that PARP protein exists in all breast tumors will help target chemo and predict response
3. Chance discovery leads to plant breeding breakthrough
4. A-maize-ing discovery could lead to higher corn yields for food, feed and fuel
5. African bird discovery proves there is something new under the sun
6. Discovery in legumes could reduce fertilizer use, aid environment: Stanford researchers
7. Startup joins UCLA tech incubator to develop technologies for drug discovery, screening
8. An electrifying discovery: New material to harvest electricity from body movements
9. New gene discovery could help to prevent blindness
10. First discovery of the female sex hormone progesterone in a plant
11. Enlisting a drug discovery technique in the battle against global warming
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/18/2016)... --> --> Competitive Landscape ... Vehicles, Physical infrastructure and Perimeter Surveillance & Detection Systems ... market and the continuing migration crisis in the ... has led visiongain to publish this unique report, which is ... & security companies in the border security market and ...
(Date:3/14/2016)... http://www.apimages.com ) - ... - Renvoi : image disponible via AP Images ( ... --> DERMALOG, le leader de l,innovation ... d,empreintes digitales pour l,enregistrement des réfugiés en Allemagne. ... produire des cartes d,identité aux réfugiés. DERMALOG dévoilera ...
(Date:3/9/2016)... , March 9, 2016 This BCC Research ... states of the RNA Sequencing (RNA Seq) market for ... as instruments, tools and reagents, data analysis, and services. ... segments of the RNA-Sequencing market such as RNA-Sequencing tools ... the main factors affecting each segment and forecast their ...
Breaking Biology News(10 mins):
(Date:5/20/2016)... CA (PRWEB) , ... May 20, 2016 , ... The ... 10 of its most experienced veterinary clients have treated over 100 of their own ... edge technology to provide the highest level of care for their patients. , ...
(Date:5/19/2016)... MAPLE RIDGE, British Columbia , May 19, ... of AdvanTec Global Innovations Inc. (AGI), based out ... recently added Greenlane Biogas Ltd. to its ... a 2-year contract manufacturing agreement. AFS along with ... Bending Technologies (ABT) is a vertically integrated industrial ...
(Date:5/18/2016)... Irvine, Calif. (PRWEB) , ... May 18, 2016 , ... ... had awarded the Luis Villalobos Award to Cognition Therapeutics at the annual ACA Summit ... innovative company that is financed by one of ACA’s member angel groups. It is ...
(Date:5/18/2016)... ... May 18, 2016 , ... The Academy of Model Aeronautics has ... dream of reaching a total of $1 million in awarded scholarships. , The AMA ... school graduates from across the nation has helped bring the total of AMA scholarships ...
Breaking Biology Technology: