Navigation Links
New discovery in living cell signaling
Date:7/3/2014

l's surface that detect and interact with the environment. Signals from these receptors are transmitted to chemical networks within the cell that process the incoming information, make decisions, and direct subsequent cellular activities.

"Although cellular signaling networks perform logical operations like a computer microprocessor, they do not operate in the same way," Groves says. "The individual computational steps in a standard computer are deterministic; the outcome is determined by the inputs. For the chemical reactions that compose a cellular signaling network, however, the molecular level outcomes are defined by probabilities only. This means that the same input can lead to different outcomes."

For cellular signaling networks involving large numbers of protein molecules, the outcome can be directly determined by the process of averaging. Even though the behavior of an individual protein is intrinsically variable, the average behavior from a large group of identical proteins is precisely determined by molecular level probabilities. Ras activation in a living cell, however, involves a relatively small number of SOS molecules, making it impossible to average the variable behavior of the individual molecules. This variation is referred to as stochastic "noise" and has been widely viewed by scientists as an error a cell must overcome.

"Our study showed that, in fact, an important aspect of the SOS signal that activates Ras is encoded in the noise," says Groves. "The protein's dynamic fluctuations between different states of activity transmit information, which means we have found a regulatory coupling in a protein signaling reaction that is entirely based on dynamics, without any trace of the signal being seen in the average behavior."

The Ras Enigma

Ras proteins are essential components of signaling networks that control cellular proliferation, differentiation and survival. Mutations in Ras genes were the
'/>"/>

Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Discovery of Earths northernmost perennial spring
2. Discovery of a bud-break gene could lead to trees adapted for a changing climate
3. The transmission of information via proteins could revolutionize drug discovery
4. Scientists weed out pesky poison ivy with discovery of killer fungus
5. Amber discovery indicates Lyme disease is older than human race
6. Promising discovery in the fight against antibiotic-resistant bacteria
7. New discovery: Molecule links asthma and cancer and could aid in developing new treatments
8. Scientists at the UA make critical end-stage liver disease discovery
9. Autism Genome Project delivers genetic discovery
10. Mechanical forces driving breast cancer lead to key molecular discovery
11. New discovery finds missing hormone in birds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New discovery in living cell signaling
(Date:9/30/2014)... HEIGHTS, Ill. (September 30, 2014) People who suffer ... can do to control their asthma besides properly taking ... a new article in the Annals of Allergy, ... American College of Allergy, Asthma and Immunology (ACAAI), asthma ... examining their lifestyle. The woman described in the Annals ...
(Date:9/29/2014)... , coupled with a high-fat diet, may cause animals to ... mBio , the online open-access journal of the American Society ... Institute of Human Nutrition Potsdam-Rehbruecke in Nuthetal observed that mice ... weight when fed a high-fat diet. Mice that did not ... consuming a high-fat diet, and mice that had C. ...
(Date:9/29/2014)... -- Plants have a symbiotic relationship with certain ... nutrients and defend against invaders an important ... vegetables. Now, scientist have discovered that plants may ... ensuring that sprouting plants are colonized from the ... Dame, presented their findings today at the 5th ...
Breaking Biology News(10 mins):Asthma symptoms kicking up? Check your exposure to air pollution 2Gut bacteria promote obesity in mice 2Plants prepackage beneficial microbes in their seeds 2
... common knowledge that smoking is a health risk but why ... In an evaluation for Faculty of 1000 Biology, Neil Grunberg ... Grunberg describes the study, published by Natividad et al. ... "may have implications to help understand why adolescents are particularly ...
... of hake, lumpsucker and salmon is the best dietary source of ... the University of Almera (UAL). The scientists analysed the eggs, or ... high levels of these fatty acids, which are essential to the ... of the nutritional potential of the roe of marine animals, but ...
... nations are gathered at the two-week UN Climate ... distinguished guests attended an ESA-hosted side event entitled ... Variables,. During the event, speakers from various ... play in providing systematic global climate observations. These ...
Cached Biology News:Roe of marine animals is best natural source of omega-3 2Space agencies join forces to systematically observe climate variables 2Space agencies join forces to systematically observe climate variables 3
(Date:9/30/2014)... available in German . ... quantum dots in a semiconductor layer. Quantum dots are small ... processes. If a short laser pulse is fired at the ... dot experiences a change in the electromagnetic field around it. ... of light by the dot. As soon as the refractive ...
(Date:9/30/2014)... German . ... have demonstrated a new kind of building block for ... chips could be based on three-dimensional arrangements of nanometer-scale ... of the semiconductor industry CMOS fabrication of silicon ... collaborators at the University of Notre Dame are exploring ...
(Date:9/30/2014)... 2014 Pacific Northwest Biotechnology, LLC - ... Global Markets Direct,s, ,Pacific Northwest Biotechnology, LLC - ... of the Pacific Northwest Biotechnology, LLC,s pharmaceutical research ... information on the current therapeutic developmental pipeline of ... at various stages, therapeutics assessment by drug target, ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 Shimadzu ... extensometer, an easy-to-use and highly precise tool for ... with considerable elongation. With 1000-mm maximum movement distance, ... percent for a gauge length of 10 mm. ... measurement accuracy above 50-mm stroke and within +/- ...
Breaking Biology Technology:Ultrafast remote switching of light emission 2A new dimension for integrated circuits: 3-D nanomagnetic logic 2A new dimension for integrated circuits: 3-D nanomagnetic logic 3Pacific Northwest Biotechnology, LLC - Product Pipeline Review - 2014 2Pacific Northwest Biotechnology, LLC - Product Pipeline Review - 2014 3Shimadzu’s New Long-Travel Extensometer Increases Precision for Soft Material Testing 2
... AAFS Convention -- With,tomorrow,s release of the Forensics ... Forensic Science Organizations (CFSO) has announced that: , ... be available to the media for comment,on the Forensics ... of,Sciences on Wednesday, February 18th at 1:00 pm EST. ...
... Idenix Pharmaceuticals, Inc. (Nasdaq: IDIX ), a biopharmaceutical ... the treatment of human viral and other infectious diseases, today ... ended December 31, 2008. At December 31, 2008, Idenix,s cash, ... , , ...
... Even Among Companies Doing Well, Relationships Weaken in Many CountriesNEW ... physicians in four out of the five major European countries ... top marks for effectively delivering key sales and service activities. ... ties with Novartis in the UK and Germany. In ...
Cached Biology Technology:CFSO Calls for Roundtable to Develop National Strategy for Advancing Forensic Sciences in the United States 2Idenix Pharmaceuticals Reports Fourth Quarter and Year End Financial Results 2Idenix Pharmaceuticals Reports Fourth Quarter and Year End Financial Results 3Idenix Pharmaceuticals Reports Fourth Quarter and Year End Financial Results 4Idenix Pharmaceuticals Reports Fourth Quarter and Year End Financial Results 5Idenix Pharmaceuticals Reports Fourth Quarter and Year End Financial Results 6Idenix Pharmaceuticals Reports Fourth Quarter and Year End Financial Results 7Physicians in Europe Rate Novartis #1 on Service Delivery, While Merck Earns Top Honors in the US 2Physicians in Europe Rate Novartis #1 on Service Delivery, While Merck Earns Top Honors in the US 3Physicians in Europe Rate Novartis #1 on Service Delivery, While Merck Earns Top Honors in the US 4Physicians in Europe Rate Novartis #1 on Service Delivery, While Merck Earns Top Honors in the US 5Physicians in Europe Rate Novartis #1 on Service Delivery, While Merck Earns Top Honors in the US 6Physicians in Europe Rate Novartis #1 on Service Delivery, While Merck Earns Top Honors in the US 7
Poly A Polymerase catalyzes the addition of AMP to the 3' hydroxyl terminus of RNA. Poly A Polymerase can add poly(C) and poly(U) to RNA but does so with much-reduced efficiency....
... PCR specificity *High PCR specificity ... with unique QIAGEN PCR Buffer ... by the stringent built-in hot start ... Mix and simple reaction setup at ...
Recombinant Ovine IFN Tau. Active on sheep, cow, human and mouse cells. Activity: 5.7 x 10 7 u/mg...
Request Info...
Biology Products: