Navigation Links
New discovery in living cell signaling
Date:7/3/2014

l's surface that detect and interact with the environment. Signals from these receptors are transmitted to chemical networks within the cell that process the incoming information, make decisions, and direct subsequent cellular activities.

"Although cellular signaling networks perform logical operations like a computer microprocessor, they do not operate in the same way," Groves says. "The individual computational steps in a standard computer are deterministic; the outcome is determined by the inputs. For the chemical reactions that compose a cellular signaling network, however, the molecular level outcomes are defined by probabilities only. This means that the same input can lead to different outcomes."

For cellular signaling networks involving large numbers of protein molecules, the outcome can be directly determined by the process of averaging. Even though the behavior of an individual protein is intrinsically variable, the average behavior from a large group of identical proteins is precisely determined by molecular level probabilities. Ras activation in a living cell, however, involves a relatively small number of SOS molecules, making it impossible to average the variable behavior of the individual molecules. This variation is referred to as stochastic "noise" and has been widely viewed by scientists as an error a cell must overcome.

"Our study showed that, in fact, an important aspect of the SOS signal that activates Ras is encoded in the noise," says Groves. "The protein's dynamic fluctuations between different states of activity transmit information, which means we have found a regulatory coupling in a protein signaling reaction that is entirely based on dynamics, without any trace of the signal being seen in the average behavior."

The Ras Enigma

Ras proteins are essential components of signaling networks that control cellular proliferation, differentiation and survival. Mutations in Ras genes were the
'/>"/>

Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Discovery of Earths northernmost perennial spring
2. Discovery of a bud-break gene could lead to trees adapted for a changing climate
3. The transmission of information via proteins could revolutionize drug discovery
4. Scientists weed out pesky poison ivy with discovery of killer fungus
5. Amber discovery indicates Lyme disease is older than human race
6. Promising discovery in the fight against antibiotic-resistant bacteria
7. New discovery: Molecule links asthma and cancer and could aid in developing new treatments
8. Scientists at the UA make critical end-stage liver disease discovery
9. Autism Genome Project delivers genetic discovery
10. Mechanical forces driving breast cancer lead to key molecular discovery
11. New discovery finds missing hormone in birds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New discovery in living cell signaling
(Date:10/15/2014)... PORT WASHINGTON, N.Y. , Oct. 15, 2014 ... in technology solutions for home and community-based care, ... the benefits of implementing Sandata,s Santrax® Electronic Visit ... Quality Care Services is a home health company ... Texas . ...
(Date:10/15/2014)... The German Gauß-Allianz has admitted Johannes Gutenberg University ... the Rhineland-Palatinate science hub continues to maintain a ... computing. , "The acceptance of Johannes Gutenberg ... Gauß-Allianz is a milestone in the national and ... support. The state of Rhineland-Palatinate can be proud ...
(Date:10/15/2014)... Conn. , Oct. 15, 2014 NXT-ID, Inc. (NASDAQ: ... biometric authentication company focused on the growing mobile commerce market releases ... MarketSite in Times Square on Monday October 13 th . ... CTO David Tunnel and angel investor Mr. Chad ... Pereira , CEO of NXT-ID thanked his investors and employees "for ...
Breaking Biology News(10 mins):Sandata Announces Case Study with Quality Care Services, Inc. 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 3Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 3
... of the Walter and Eliza Hall Institute of Medical ... of the 2009 Pearl Meister Greengard Prize. ... the accomplishments of outstanding female scientists, at The Rockefeller ... prize was founded by Rockefeller Nobel laureate Paul Greengard ...
... highlands split and the Great Rift Valley formed, the ... different atmospheric circulation patterns than it does today, according ... central African nation. Neil J. Tabor, associate professor ... and an expert in sedimentology and isotope geochemistry, calculated ...
... over could benefit from new software* created at the National ... scientists has found a way to improve the efficiency of ... Alabama at Birmingham (UAB). Pneumonia is the world,s leading ... and poses a serious risk to elderly adults. The leading ...
Cached Biology News:Professor Suzanne Cory awarded 2009 Pearl Meister Greengard Prize 2Ethiopia's climate 27 million years ago had higher rainfall, warmer soil 2Scientists create NICE solution to pneumonia vaccine testing problems 2
(Date:10/20/2014)... , Oct. 20, 2014  GenVec, Inc. (NASDAQ: ... P. Horovitz , Ph.D., from its board of directors effective ... in August 2003, and served as its chairman from June ... on the Nominating and Corporate Governance and Audit Committees of ... more than a decade of dedicated service to GenVec, and ...
(Date:10/20/2014)... 20, 2014 Earle Martin ... announced today that Ellen Teplitzky, an experienced attorney ... the pharmaceutical industry, has joined the firm as ... legal services practice. NDA Partners provides legal ... and testimony, to top law firms and their ...
(Date:10/19/2014)... 20, 2014 OCTOBER 20-22, ... (ABIM). ABIM will take place at ... about ABIM 2014 is now available at ... representing companies and organizations from all over ... information on the latest products and developments ...
(Date:10/19/2014)... 2014 The Asian Automatic patient billing ... analysis and forecast of revenue. The Automatic patient billing ... $463.9 million by 2018, at a developing CAGR of ... TOC of the Asian Automatic patient billing market, to ... also provides a glimpse of the segmentation of this ...
Breaking Biology Technology:Zola P. Horovitz To Retire From GenVec Board 2NDA Partners Appoints Ellen Teplitzky, JD as Director of its Legal Services Practice 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 3
... , , , ... be key regulators of lipid, glucose and overall energy metabolism. Bile acid ... energy expenditure in muscle and brown fat, thereby conferring resistance to weight ... Metabolism (Vol. 10, Issue 3, Sept. 2, 2009) elaborates on a ...
... , ST. LOUIS, Sept. 1 Express Scripts, ... following investor conferences in September: , , Thomas Weisel Partners ... Four Seasons Hotel in Boston, MA. , , Morgan Stanley ... Grand Hyatt Hotel in New York, NY. , , These ...
... PHILADELPHIA, Sept. 1 ERT (Nasdaq: ERES ), announced ... Keith Schneck, the Company,s Executive Vice President and CFO, are scheduled to ... on September 9, 2009 in New York City, New York. , ... Company,s corporate website at http://www.ert.com . The webcast may ...
Cached Biology Technology:Cell Metabolism Publishes Novel TGR5-Mediated Mechanism for the Treatment of Diabetes and Obesity 2Cell Metabolism Publishes Novel TGR5-Mediated Mechanism for the Treatment of Diabetes and Obesity 3Express Scripts to Present at Investor Conferences 2ERT to Present at Baird's 2009 Health Care Conference on September 9, 2009 2
... suspension array system, 100-240 V, uses xMAP ... to 100 proteins and peptides in one ... of up to 100 color-coded bead sets, ... a unique reactant (enzyme substrates, receptors, antigens, ...
... The high-throughput fluidics (HTF) system, 100-240 V, ... suspension array system that automates delivery of ... into the Bio-Plex array reader. The HTF ... nonpressurized bulk sheath container to constantly maintain ...
... PYREX Delong style shaker flasks have three ... agitation of solutions to improve oxygen or ... reciprocating shakers. The long neck reduces splashing ... Their uniform wall thickness provides the proper ...
... gradient system uses two Adept CE 4100 ... CE 4200 dual wavelength detector for added flexibility. ... by PowerStream data processing software and interface unit, ... The supplied analytical pumps may be substituted ...
Biology Products: