Navigation Links
New discovery by Harvard scientists aims to correct cellular defects leading to diabetes
Date:1/4/2010

A new research discovery published online in the FASEB Journal (http://www.fasebj.org) may change the perception and treatment of diabetes. That's because scientists have moved closer toward correcting the root cause of the disease rather than managing its symptoms. Specifically researchers identified a protein (G6PD protein) and its antioxidant product (NAPDH) that both prevent the death and promote the growth of cells which produce and release insulin in the pancreas (beta cells).

"Abnormally high levels of oxidants are thought to be a major cause of diabetes and the complications of diabetes, as well as many other diseases," said Robert C. Stanton, M.D., co-author of the study, from Joslin Diabetes Center in Boston. "By understanding the specific defects in processes that either produce too many oxidants or not enough antioxidants, a new era of highly specific, targeted treatments will emerge that very effectively treat or possibly prevent many of these diseases."

To make this discovery, Stanton and colleagues studied beta cells from humans and mice to determine the effects of increasing sugar on the cells, the G6PD protein, and NADPH antioxidant. Using biochemical and molecular biology techniques, researchers measured levels of various chemicals, proteins and markers of both cell growth and death. Results showed that increasing the level of sugar causes a decrease in NADPH and increased beta cell death. Additionally, tweaking the level of NADPH higher prevented the negative effects of increased sugar. Increasing the activity of G6PD rescued the beta cells from cell death, leading researchers to conclude that treatments that directly prevent G6PD decrease or promote G6PD increases could hold great promise in treating diabetes.

"Even before the 'omic revolution, the cause and cure of diabetes have long been sought," said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal. "This research discovery, which identifies a key enzyme that regulates oxidation and pancreatic cell death, brings us closer than ever to getting at the root of diabetes."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Discovery may help defang viruses
2. Stomach stem cell discovery could bring cancer insights
3. Symposium marks 30th anniversary of discovery of third domain of life
4. Emory paleontologist reports discovery of carnivorous dinosaur tracks in Australia
5. Natural product discovery by Cleveland medical researchers blocks tissue destruction
6. Researchers discovery may lead to hypertension treatment
7. Yale discovery suggests protein may play a role in severe asthma
8. Galapagos and Cystic Fibrosis Foundation Therapeutics announce drug discovery collaboration
9. Profound immune system discovery opens door to halting destruction of lupus
10. Scripps Research discovery leads to broad potential applications in CovX-Pfizer deal
11. New discovery could reduce the health risk of high-fat foods
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/24/2016)... IRVINE, Calif. , Nov. 23, 2016 ... help endurance athletes and their trainers non-invasively measure ... Variability Index, Pulse Rate, and Respiration Rate in approximately ... Ember enables users easy and immediate access to key ... as part of a training regimen. ...
(Date:11/21/2016)... Lithuania , Nov. 21, 2016   ... and object recognition technologies, today announced that the ... smart cards was submitted for the NIST ... successfully passed all the mandatory steps of the ... evaluation is a continuing test of fingerprint templates ...
(Date:11/17/2016)... 2016  AIC announces that it has just released a new white paper authored ... scale-out plus high speed data transfer storage solutions. Photo - http://photos.prnewswire.com/prnh/20161116/440463 ... ... ... Setting up a high performance computing or HPC system ...
Breaking Biology News(10 mins):
(Date:12/2/2016)... , Dec. 2, 2016 Amgen (NASDAQ: ... today announced the submission of a Marketing Authorization Application (MAA) ... biosimilar candidate to Avastin ® (bevacizumab). The companies believe ... the EMA. "The submission of ABP 215 ... to expand our oncology portfolio," said Sean E. Harper ...
(Date:12/2/2016)... Research and Markets has announced the ... and Companies" to their offering. ... , , ... biotechnology industries is anticipated. Nanotechnology will be applied at all ... to diagnostic applications in clinical trials. Many of the assays ...
(Date:12/2/2016)... ... December 01, 2016 , ... ... value of DNA microarray comparative genomic hybridization (array CGH) for HER2 genomic ... Symposium. Using molecular test results from tumors with previously documented positive, negative, ...
(Date:12/2/2016)... ... December 01, 2016 , ... ... Symposium (CSS) and the popularity of US Single Day Events (SDE) to organize ... early Summer 2018, in Raleigh, NC. Topics of the pharmaceutical and life sciences ...
Breaking Biology Technology: