Navigation Links
New discovery: Molecule links asthma and cancer and could aid in developing new treatments
Date:5/1/2014

A newly discovered molecule provides a new drug target for controlling both asthma-induced muscle thickening and cancerous tumor growth. This molecule, called "microRNA-10a," normally helps genes produce proteins or make copies of themselves, also play an important role in the growth or overgrowth of human airway smooth muscle cells and some forms of cancer. This newly discovered role, which was published in the May 2014 issue of The FASEB Journal, suggests that manipulating microRNA-10a could lead to new asthma and cancer drugs.

"We hope this study will serve as the fundamental building block for future follow-up studies on evaluating microRNA-10a's potential in treating asthma and uncontrolled tumor growth," said Quan Lu, Ph.D., a researcher involved in the work from the Program in Molecular and Integrative Physiological Sciences at the Harvard School of Public Health in Boston, MA.

Lu and colleagues made their discovery by using state-of-the-art sequencing to identify microRNA-10a as the most highly enriched microRNA molecule in the human airway smooth muscle cells. To study the function of this microRNA, researchers then used an unbiased genomic approach (microarray gene profiling) to compare the differences between cells treated with microRNA-10a and not treated (control). They found that microRNA-10a regulates pathways that control cell proliferation. To further uncover the mechanistic link of microRNA-10a and smooth muscle cell proliferation, a series of biochemical tests were conducted and demonstrated that microRNA-10a inhibits the PI3 kinase, a master regulator of cell proliferation. This strongly suggests that microRNA-10a could become a novel asthma drug target to treat airway hypertrophy, and that microRNA-10a may be a therapeutic target to treat cancer tumor growth.

"Asthma and cancer may seem to be unrelated, but this report shows that both diseases may share a
'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Surprising discovery: The skin communicates with the liver
2. A whale of a discovery: New sensory organ found in rorqual whales
3. NeuroPhage discovers GAIM-changing molecules to combat Alzheimers and related diseases
4. The 2nd International Symposium on Transformative Bio-Molecules 2014
5. Radiation able to be securely stored in nontoxic molecule, study finds
6. Newly discovered molecule may offer hope for immune disorders and runaway inflammation
7. Novel membrane reveals water molecules will bounce off a liquid surface
8. A tailor-made molecule against malaria
9. A tailor made molecule against malaria
10. Imaging dynamics of small biomolecules inside live cells
11. Is a buttery molecule behind cystic fibrosis flare-ups?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... Ebola researcher from the University of Texas Medical Branch at ... three monoclonal antibodies can completely protect monkeys against a lethal ... at a time when the disease is severe. , Thomas ... for Nature discussing advances in Ebola treatment research. ... among the most deadly of pathogens, with fatality rates of ...
(Date:8/29/2014)... release is available in German . ... signals between organisms is considered the oldest form of ... between conspecifics, for example, the sexual attraction between males ... responses and to coordinate reproductive behavior in males and ... University of the Algarve in Faro, Portugal, and at ...
(Date:8/29/2014)... Boulder, Colo., USA - The rise of the Tibetan ... on Earth -- is important for both its profound ... In this study published in GSA Bulletin , ... -- "clumped" isotope thermometry -- using modern and fossil ... Zhada basin in southwestern Tibet. , Views range ...
Breaking Biology News(10 mins):Leading Ebola researcher at UTMB says there's an effective treatment for Ebola 2Ready for mating at the right time 2Ready for mating at the right time 3Snails tell of the rise and fall of the Tibetan Plateau 2Snails tell of the rise and fall of the Tibetan Plateau 3Snails tell of the rise and fall of the Tibetan Plateau 4Snails tell of the rise and fall of the Tibetan Plateau 5Snails tell of the rise and fall of the Tibetan Plateau 6Snails tell of the rise and fall of the Tibetan Plateau 7
... of the School of Chemical Engineering and Analytical Science, has ... announced at the Science, Engineering and Technology Awards in a ... 3rd. The SET Awards are Europe,s most important awards ... for his final year design project detailed design of ...
... to cross-breeding flowers to produce pretty petals or sweet scents ... for producing new types of flowers. DNA analysis of ... of species of the plant could be derived from hybrids ... help explain the rich biodiversity of the natural world, as ...
... a paper published as the cover story of the September ... MIT have demonstrated that graphene, a surprisingly robust planar sheet ... membrane separating two liquid reservoirs. By drilling a tiny ... the graphene membrane, they were able to measure exchange of ...
Cached Biology News:Dyfan is Chemical Engineering Student of the Year 2Nature's gift for gardening may hold key to biodiversity 2Graphene may hold key to speeding up DNA sequencing 2Graphene may hold key to speeding up DNA sequencing 3
(Date:8/28/2014)... MA (PRWEB) August 28, 2014 ... wholesale construction materials, selected SoundConnect to ... their cloud based audio and web conferencing platform ... to support PrimeSource’s employees’ needs. SoundConnect delivers ... , PrimeSource Building Products will be utilizing ...
(Date:8/27/2014)... Varian Medical Systems today broke ground ... Lake City manufacturing facility and allow for the consolidation ... create 1,000 new full time jobs in the state ... home to hardworking people with immense engineering and technical ... success in the manufacturing of our state-of-the-art X-ray technology,” ...
(Date:8/27/2014)... In 2013, Lawrence Livermore National ... Security LLC (LLNS), was awarded more than ... laser system for the European Union's Extreme Light ... the Czech Republic. , When commissioned to its ... " High repetition-rate Advanced Petawatt Laser System " ...
(Date:8/27/2014)... how plants survive impact by the huge amounts ... using this energy for photosynthesis. The hypothesis is ... quickly dissipate the energy throughout the entire protein ... Physics have now managed to successfully ,film, this ... light-absorbing proteins which play a role in photosynthesis ...
Breaking Biology Technology:PrimeSource Chooses SoundConnect as Collaboration Provider 2Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 2Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 3LLNL Synchs up with ELI Beamlines on Timing System 2LLNL Synchs up with ELI Beamlines on Timing System 3DTU researchers film protein quake for the first time 2
... Verenium Corporation (Nasdaq: VRNM ), a ... today announced that it has entered into an agreement ... United States ("Ex-Im Bank") for two 18-month, secured revolving ... These new credit facilities will allow the Company ...
... 2011 PharmaVentures today announced the launch of ... Essential Deal Trends: Oncology 2011 . This new series ... and commercialising new drugs. The first report in the series ... active deal making therapeutic area in the pharmaceutical and biotechnology ...
... cell carcinomas are amongst the most frequent cancers in ... like many other human cancers, contain particular cancer cells, ... potential that sustain tumor growth. Little is known about ... High level of VEGF expression in skin cancer ...
Cached Biology Technology:Verenium Announces Up to $16 Million in New Secured Financings 2Verenium Announces Up to $16 Million in New Secured Financings 3Pfizer, Sanofi and Genentech Feature Prominently in the Oncology Edition of PharmaDeals' New Publication Series; Essential Deal Trends 2Pfizer, Sanofi and Genentech Feature Prominently in the Oncology Edition of PharmaDeals' New Publication Series; Essential Deal Trends 3New role for Vascular Endothelial Growth Factor in regulating skin cancer stem cells 2
... High performance agitation and temperature control ... controls four wells independently and is suitable ... 1.5 L working volume. Its temperature ranges ... . Each well is equipped with an ...
RORgamma (S-14)...
... The RSH-4000 is the only microplate ... It offers long walkaway times with a ... ,Features: , Fully automated with integrated stacker ... Hudsons PlateCrane EX for use in small ...
... provides a comprehensive service for custom ... peptide microarrays synthesized on Paraflo microfluidic ... proteins/antibodies or serum samples. This comprehensive ... designs, binding assays using sample(s) provided ...
Biology Products: