Navigation Links
New discovery: Molecule links asthma and cancer and could aid in developing new treatments
Date:5/1/2014

A newly discovered molecule provides a new drug target for controlling both asthma-induced muscle thickening and cancerous tumor growth. This molecule, called "microRNA-10a," normally helps genes produce proteins or make copies of themselves, also play an important role in the growth or overgrowth of human airway smooth muscle cells and some forms of cancer. This newly discovered role, which was published in the May 2014 issue of The FASEB Journal, suggests that manipulating microRNA-10a could lead to new asthma and cancer drugs.

"We hope this study will serve as the fundamental building block for future follow-up studies on evaluating microRNA-10a's potential in treating asthma and uncontrolled tumor growth," said Quan Lu, Ph.D., a researcher involved in the work from the Program in Molecular and Integrative Physiological Sciences at the Harvard School of Public Health in Boston, MA.

Lu and colleagues made their discovery by using state-of-the-art sequencing to identify microRNA-10a as the most highly enriched microRNA molecule in the human airway smooth muscle cells. To study the function of this microRNA, researchers then used an unbiased genomic approach (microarray gene profiling) to compare the differences between cells treated with microRNA-10a and not treated (control). They found that microRNA-10a regulates pathways that control cell proliferation. To further uncover the mechanistic link of microRNA-10a and smooth muscle cell proliferation, a series of biochemical tests were conducted and demonstrated that microRNA-10a inhibits the PI3 kinase, a master regulator of cell proliferation. This strongly suggests that microRNA-10a could become a novel asthma drug target to treat airway hypertrophy, and that microRNA-10a may be a therapeutic target to treat cancer tumor growth.

"Asthma and cancer may seem to be unrelated, but this report shows that both diseases may share a common molecular link," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "With potential applications in asthma and cancer treatment, hopefully future research into this regulatory molecule can be accelerated."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Surprising discovery: The skin communicates with the liver
2. A whale of a discovery: New sensory organ found in rorqual whales
3. NeuroPhage discovers GAIM-changing molecules to combat Alzheimers and related diseases
4. The 2nd International Symposium on Transformative Bio-Molecules 2014
5. Radiation able to be securely stored in nontoxic molecule, study finds
6. Newly discovered molecule may offer hope for immune disorders and runaway inflammation
7. Novel membrane reveals water molecules will bounce off a liquid surface
8. A tailor-made molecule against malaria
9. A tailor made molecule against malaria
10. Imaging dynamics of small biomolecules inside live cells
11. Is a buttery molecule behind cystic fibrosis flare-ups?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2016)... 22, 2016 On Monday, the Department of ... to share solutions for the Biometric Exit Program. The ... Border Protection (CBP), explains that CBP intends to add ... the United States , in order to ... imposters. Logo - http://photos.prnewswire.com/prnh/20160622/382209LOGO ...
(Date:6/16/2016)... The global Biometric ... USD 1.83 billion by 2024, according to a ... proliferation and increasing demand in commercial buildings, consumer ... the market growth.      (Logo: ... of advanced multimodal techniques for biometric authentication and ...
(Date:6/9/2016)... , June 9, 2016 ... deploy Teleste,s video security solution to ensure the safety of ... during the major tournament Teleste, an ... systems and services, announced today that its video security solution ... to back up public safety across the country. The ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Houston Methodist ... the Cy-Fair Sports Association to serve as their ... agreement, Houston Methodist Willowbrook will provide sponsorship support, ... connectivity with association coaches, volunteers, athletes and families. ... the Cy-Fair Sports Association and to bring Houston ...
(Date:6/23/2016)... Prostate Cancer Foundation (PCF) is pleased to announce 24 new Young Investigator ... Members of the Class of 2016 were selected from a pool of 128 ... About the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... FRANCISCO , June 23, 2016   EpiBiome ... has secured $1 million in debt financing from Silicon ... ramp up automation and to advance its drug development ... its new facility. "SVB has been an ... beyond the services a traditional bank would provide," said ...
(Date:6/23/2016)... ... ... STACS DNA Inc., the sample tracking software company, today announced that Dr. Hays ... DNA as a Field Application Specialist. , “I am thrilled that Dr. Young ... DNA. “In further expanding our capacity as a scientific integrator, Hays brings a wealth ...
Breaking Biology Technology: