Navigation Links
New discovery: Molecule links asthma and cancer and could aid in developing new treatments
Date:5/1/2014

A newly discovered molecule provides a new drug target for controlling both asthma-induced muscle thickening and cancerous tumor growth. This molecule, called "microRNA-10a," normally helps genes produce proteins or make copies of themselves, also play an important role in the growth or overgrowth of human airway smooth muscle cells and some forms of cancer. This newly discovered role, which was published in the May 2014 issue of The FASEB Journal, suggests that manipulating microRNA-10a could lead to new asthma and cancer drugs.

"We hope this study will serve as the fundamental building block for future follow-up studies on evaluating microRNA-10a's potential in treating asthma and uncontrolled tumor growth," said Quan Lu, Ph.D., a researcher involved in the work from the Program in Molecular and Integrative Physiological Sciences at the Harvard School of Public Health in Boston, MA.

Lu and colleagues made their discovery by using state-of-the-art sequencing to identify microRNA-10a as the most highly enriched microRNA molecule in the human airway smooth muscle cells. To study the function of this microRNA, researchers then used an unbiased genomic approach (microarray gene profiling) to compare the differences between cells treated with microRNA-10a and not treated (control). They found that microRNA-10a regulates pathways that control cell proliferation. To further uncover the mechanistic link of microRNA-10a and smooth muscle cell proliferation, a series of biochemical tests were conducted and demonstrated that microRNA-10a inhibits the PI3 kinase, a master regulator of cell proliferation. This strongly suggests that microRNA-10a could become a novel asthma drug target to treat airway hypertrophy, and that microRNA-10a may be a therapeutic target to treat cancer tumor growth.

"Asthma and cancer may seem to be unrelated, but this report shows that both diseases may share a common molecular link," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "With potential applications in asthma and cancer treatment, hopefully future research into this regulatory molecule can be accelerated."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Surprising discovery: The skin communicates with the liver
2. A whale of a discovery: New sensory organ found in rorqual whales
3. NeuroPhage discovers GAIM-changing molecules to combat Alzheimers and related diseases
4. The 2nd International Symposium on Transformative Bio-Molecules 2014
5. Radiation able to be securely stored in nontoxic molecule, study finds
6. Newly discovered molecule may offer hope for immune disorders and runaway inflammation
7. Novel membrane reveals water molecules will bounce off a liquid surface
8. A tailor-made molecule against malaria
9. A tailor made molecule against malaria
10. Imaging dynamics of small biomolecules inside live cells
11. Is a buttery molecule behind cystic fibrosis flare-ups?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/14/2016)... , Allemagne, March 14, 2016 ... ) - --> - Renvoi : image ... --> --> ... biométriques, fournit de nouveaux lecteurs d,empreintes digitales pour ... de DERMALOG sera utilisé pour produire des cartes ...
(Date:3/10/2016)... India , March 10, 2016 ... a new market research report "Identity and Access Management ... & Audit, Compliance, and Governance), by Organization Size, by ... to 2020", published by MarketsandMarkets, The market is estimated ... USD 12.78 Billion by 2020, at a Compound Annual ...
(Date:3/9/2016)... , March 9, 2016 ... government identified that more than 23,000 public service employees ... had been receiving their salary unlawfully.    --> ... country,s government identified that more than 23,000 public service ... or had been receiving their salary unlawfully.    ...
Breaking Biology News(10 mins):
(Date:5/25/2016)... ... May 25, 2016 , ... Biohaven Pharmaceutical ... (FDA) has granted the company’s orphan drug designation request covering BHV-4157 for the ... granted by the FDA. , Spinocerebellar ataxia is a rare, debilitating neurodegenerative ...
(Date:5/24/2016)... TEL AVIV, Israel , May 24, 2016   ... on providing physicians with artificial intelligence, real-time decision support tools ... selected to present at the 2016 Israeli Advanced Technology Industries ... part of Israel,s 15th National Life ... to 26th at the David Intercontinental Hotel in ...
(Date:5/24/2016)... ... May 24, 2016 , ... Media Cybernetics, global image ... Cybernetics corporate branding reflects a results-driven revitalization for a company with a renewed ... components include a crisp, refreshed logo and a new web presence. , “I ...
(Date:5/23/2016)... ... May 23, 2016 , ... PrecisionAg® ... Farming in 2017 and Beyond. The paper outlines the key trends that are ... industry. , “We’ve witnessed a lot of highs and lows as the precision ...
Breaking Biology Technology: