Navigation Links
New discoveries make it harder for HIV to hide from drugs
Date:12/15/2010

The virus that causes AIDS is chameleon-like in its replication. As HIV copies itself in humans, it constantly mutates into forms that can evade even the best cocktail of current therapies. Understanding exactly how HIV cells change as they reproduce is key to developing better tests and treatments for patients.

In the Journal of Biological Chemistry and Nature Structural & Molecular Biology, MU microbiologist and biochemist Stefan Sarafianos, PhD, reveals new findings that shed light on how HIV eludes treatment by mutating. His discoveries provide clues into HIV's mechanisms for resisting two main families of drugs.

"These findings are important because identifying a new mutation that affects HIV drug resistance allows physicians to make better decisions and prescribe the proper drugs," Sarafianos said. "Without that knowledge, therapy can be suboptimal and lead to early failure."

Patients with HIV are routinely tested to track the levels of the virus and immune cells in their body. Results of the tests help physicians gauge the health of their patients and prescribe the right mix of antiviral drugs. The drugs help prevent the spread of HIV in patients by inhibiting the virus' ability to replicate.

Sarafianos' lab determined the biochemical properties that allow strains of HIV with a specific mutation the N348I mutation to escape inhibition despite treatment with Nevirapine. The drug is commonly used in combination with other antiviral medications to decrease the amount of HIV in the blood. As a result of Sarafianos' discovery, at least one major company that manufactures HIV mutation-testing kits has modified its test to detect the N348I mutation.

Sarafianos' recent findings resulted from research supported by five National Institutes of Health grants. He recently received another $417,000 award from the NIH to assist him in developing modified antibodies for HIV therapy.

"Our latest efforts to design broadly neutralizing antibodies against HIV will hopefully expand our toolbox against the virus, which remains a constantly moving target," Sarafianos said.


'/>"/>

Contact: Natalie Fieleke
fieleken@health.missouri.edu
573-882-9193
University of Missouri School of Medicine
Source:Eurekalert

Related biology news :

1. UTHealth discoveries shed more light on deadly thoracic aortic disease
2. New discoveries in North Americas Great Plains bring ammonites to life
3. Nanoparticle scientist speaks on new discoveries at Goldschmidt Conference
4. Charles Drew University researcher will be honored for discoveries
5. Society of Interventional Radiology highlights medical advances, new discoveries
6. New discoveries could improve climate projections
7. UCR plant scientists research spawns new discoveries showing how crops survive drought
8. Partnership to accelerate Trudeau Institute discoveries to patient care
9. MSU discoveries upend traditional thinking about how plants make certain compounds
10. Field stations foster serendipitous discoveries in environmental, biological sciences
11. UC and partners awarded $23 million to transform discoveries into real-world health solutions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2016)... , March 29, 2016 LegacyXChange, ... LegacyXChange "LEGX" and SelectaDNA/CSI Protect are pleased to announce ... used in a variety of writing instruments, ensuring athletes ... originally created collectibles from athletes on LegacyXChange will be ... of the DNA. Bill Bollander , ...
(Date:3/22/2016)... PROVO and SANDY, Utah ... (NSO), which operates the highest sample volume laboratory in ... Tute Genomics and UNIConnect, leaders in clinical sequencing informatics ... the launch of a project to establish the informatics ... NSO has been contracted by the ...
(Date:3/17/2016)... , March 17, 2016 ABI ... intelligence, forecasts the global biometrics market will reach ... impressive 118% increase from 2015. Consumer electronics, particularly ... embedded fingerprint sensors anticipated to reach two billion ... Dimitrios Pavlakis , Research Analyst at ...
Breaking Biology News(10 mins):
(Date:4/27/2016)... (PRWEB) , ... April 27, 2016 , ... ... Touch screen mobile devices with fingerprint recognition for secure access, voice recognition ... only a few ways consumers are interacting with biometrics technology today. But ...
(Date:4/27/2016)... ... 27, 2016 , ... NDA Partners Chairman Carl Peck, ... Expert Consultant. Mr. Clark was formerly a Vice President with US Pharmacopeia, ... molecule monographs based on analytical methods. NDA Partners Expert Consultants are top ...
(Date:4/27/2016)... ... 27, 2016 , ... Global Stem Cells Group and the University ... other research and development initiatives for potential stem cell protocol management for 2016 – ... Group executives began meeting to establish a working agenda and foster initiatives to promote ...
(Date:4/26/2016)... CA (PRWEB) , ... April 26, 2016 , ... ... healthcare, today announced that Ardy Arianpour has joined the company as Chief Business ... of experience bringing innovative genomic technologies to market, was most recently Chief Commercial ...
Breaking Biology Technology: