Navigation Links
New discoveries in genetics of lung health
Date:9/25/2011

Scientists have for the first time discovered sixteen new sections of the genetic code that relate to lung health -- opening up the possibility for better prevention as well as treatment for lung diseases.

An international consortium of 175 scientists from 126 centres in Europe, the USA and Australia identified genetic variants associated with the health of the human lung. Their discovery sheds new light on the molecular basis of lung diseases like Chronic Obstructive Pulmonary Disease (COPD).

It is the first time that these sixteen common genetic variants have been definitely linked with lung function. Researchers say the new pathways discovered could be targeted by drugs.

The study was led by Professor Martin Tobin from the University of Leicester, and Professor Ian Hall from The University of Nottingham and Dr Stephanie London from the U.S. National Institute of Environmental Health Sciences.

The pioneering research involved a genetic study of 2.5 million genetic variants in each of 48,201 people across the world. A smaller number of the most promising variants were then studied in a further 46,411 individuals. The research, part-funded by the UK Medical Research Council (MRC) and the Wellcome Trust, is published today in Nature Genetics.

The recent discoveries build on research published by the same authors last year, bringing the total number of genetic variants associated with lung function to twenty six. The same authors also showed, in research published in the American Journal of Respiratory and Critical Care Medicine in June 2011, that variants which predict lung function also predict the disease, COPD.

Professor Martin Tobin, Professor of Genetic Epidemiology and Public Health & MRC Senior Clinical Fellow at the University of Leicester, said: "COPD - a progressive disease that makes it hard for people to breathe - affects around 1 in 10 adults above the age of 40 and is fourth most common cause of death worldwide.

"Smoking is the most important risk for developing COPD. Smokers are not all equally likely to develop COPD and differences in susceptibility occur due to the genetic variants people carry. For the first time we understand what so many of these genetic variants are, including the underlying mechanisms that they point to. We now need to prioritise research to better understand these disease mechanisms and inform improved patient care.

"These discoveries could provide the key to new therapies for lung diseases such as COPD. It is too early to say whether this information would be of use as a screening test to predict the development of COPD. Stopping smoking is the best way to prevent COPD.

Professor Ian Hall said "This work is important because until recently we have not understood the factors which underlie inherited variability in lung function. The very large genetic studies required to identify key genes would not have been possible without the support of many groups around the world and the input of thousands of subjects. We now need to take the knowledge gained from this study to do two things: firstly to learn more about the function of genes which contribute to the risk of developing lung diseases such as COPD, and secondly to try and develop strategies to use genetic information to improve the clinical care provided to individual patients."


'/>"/>

Contact: Dr Martin Tobin
mt47@leicester.ac.uk
44-011-622-97270
University of Leicester
Source:Eurekalert

Related biology news :

1. Breakthrough lights way for RNA discoveries
2. Grants awarded to help bring promising bioscience discoveries to market
3. Discoveries in mitochondria open new field of cancer research
4. Drugs from the sea: New discoveries in marine biomedicine
5. Researcher to present discoveries on medical uses of ultrasound to Londons Royal Society
6. Researcher to present discoveries on medical uses of ultrasound to London’s Royal Society
7. Pivotal discoveries in age-related macular degeneration
8. New discoveries improve climate models
9. New discoveries make it harder for HIV to hide from drugs
10. UTHealth discoveries shed more light on deadly thoracic aortic disease
11. New discoveries in North Americas Great Plains bring ammonites to life
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/7/2017)... 2017   MedNet Solutions , an innovative SaaS-based ... clinical research, is pleased to announce that the latest ... highly flexible and award winning eClinical solution, is now ... is a proven Software-as-a-Service (SaaS) clinical research technology ... but also delivers an entire suite of eClinical tools ...
(Date:2/3/2017)... Biomedical Research Institute announced that its Board of Trustees has ... Institute,s new President and CEO. Dr. Schlesinger will take the ... currently the Chair of the Department of Microbial Infection and ... at Ohio State University. "We are delighted to ... Texas Biomed," said Dr. James O. Rubin , Board ...
(Date:2/2/2017)... 2017  Central to its deep commitment to ... The Japan Prize Foundation today announced the laureates ... the envelope in their respective fields of Life ... are being recognized with the 2017 Japan Prize ... contribute to the advancement of science and technology, ...
Breaking Biology News(10 mins):
(Date:2/21/2017)... and VANCOUVER, British Columbia , Feb. 21, ... today announced that apatorsen results from two randomized Phase 2 ... Oncology (ASCO) 2017 Genitourinary Cancers Symposium, held February 16 th ... Clinical data from trials in bladder and prostate cancers demonstrated ... combination with standard-of-care treatments. ...
(Date:2/21/2017)...   Logicalis Healthcare Solutions , the healthcare-focused practice ... services provider ( www.us.logicalis.com ), today announced a new ... new service will help hospital CIOs make the best ... nurses and other clinicians immediate access to a pool ... allow hospital IT staff to focus on broader issues ...
(Date:2/21/2017)... 21, 2017   Invitae Corporation (NYSE: NVTA), ... announced that members of the company,s management team will ... Care Conference on Monday, March 6, 2017 at approximately ... Boston, Massachusetts . The ... by visiting the investors section of the company,s website ...
(Date:2/20/2017)... ... February 20, 2017 , ... Global relationship marketing ... approved for full, active membership in the Canadian Direct Sellers Association (DSA) effective ... Executive Officer Jeff Olson in 2011. Today Nerium International, with its ...
Breaking Biology Technology: