Navigation Links
New discoveries about severe malaria
Date:5/21/2012

se," explained Lavstsen. Co-author Louise Turner, Ph.D. adds "Another important aspect of our study is that we show these PfEMP1 domain cassettes are recognized by natural acquired immunity in young African children, which gives us hope that we can base a vaccine on the discovered PfEMP1 types."

In a related paper in this issue, Antoine Claessens, Ph.D., who works in the lab of Alexandra Rowe, D. Phil., of the University of Edinburgh, reports that these particular PfEMP1 types domain cassettes 8 and 13 mediate the binding of infected red blood cells to cells that line blood vessels in the brain. "This provides us with new molecules that could be targeted to develop drugs to treat the most deadly forms of malaria," said Rowe. "In addition, because animal models for cerebral malaria are currently unavailable, we believe our findings might lead to a laboratory tool for testing drugs and vaccines that block the binding of the parasite to blood vessels in the brain."

Marion Avril, Ph.D., who works in the Smith lab at Seattle BioMed, reports in this issue that domain cassette 8 encodes binding activity for brain blood vessel cells. Additionally, the authors uncovered a potential explanation for the evolutionary persistence of parasite protein variants that mediate cerebral malaria, an often-fatal disease that tends to wipe out the parasite's host.

"Because those brain-binding variants can also bind to blood vessels in the skin, heart, and lung, the parasite might sequester in those organs," Smith explained. "Together, the findings could help researchers better address the lingering problem of childhood malaria."

"It's been a 15-year journey since this gene family was discovered, but the coming together of these three studies, which all identify the same key players in severe malaria, is an important milestone," said Rowe. "We're excited to have this knowledge and begin to apply it to developing new solutions for malaria."


'/>"/>

Contact: Jennifer Mortensen
jennifer.mortensen@seattlebiomed.org
206-256-7220
Seattle Biomedical Research Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. UC and partners awarded $23 million to transform discoveries into real-world health solutions
2. Field stations foster serendipitous discoveries in environmental, biological sciences
3. MSU discoveries upend traditional thinking about how plants make certain compounds
4. Partnership to accelerate Trudeau Institute discoveries to patient care
5. UCR plant scientists research spawns new discoveries showing how crops survive drought
6. New discoveries could improve climate projections
7. Society of Interventional Radiology highlights medical advances, new discoveries
8. Charles Drew University researcher will be honored for discoveries
9. Nanoparticle scientist speaks on new discoveries at Goldschmidt Conference
10. New discoveries in North Americas Great Plains bring ammonites to life
11. UTHealth discoveries shed more light on deadly thoracic aortic disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... -- Unisys Corporation,s (NYSE: UIS ) subsidiary in ... that it has been selected by the Dutch Custodial Institutions ... Provision Biometrics solution for penitentiaries across The Netherlands ... a solution based on its open standards-based LEIDA ... is up to seven years, with the new system expected ...
(Date:7/10/2014)... 3, 2014 According to the ... (Swipe And Area), Material (Optical Prism, Pizeoelectric, Capacitive, and ... and Banking & Finance), and Geography - Global Trends ... the global Fingerprint Sensors Market is projected to cross ... of 16.8% from 2014 to 2020. Browse ...
(Date:7/10/2014)... 7, 2014 According to a ... Access Control Systems Market Global Forecast, Market Share, Size, ... Electronic Access Control systems market was valued at USD ... at a CAGR of 12.6% from 2014 to 2019, ... in 2019. Browse the full Electronic Access ...
Breaking Biology News(10 mins):Unisys Delivers New Basic Provision Biometrics Solution to Dutch Custodial Institutions Service 2Unisys Delivers New Basic Provision Biometrics Solution to Dutch Custodial Institutions Service 3Fingerprint Sensors Market worth $14.35 Billion by 2020 2Fingerprint Sensors Market worth $14.35 Billion by 2020 3Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 2Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 3Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 4Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 5
... 2008 -- A rat thought extinct for 11 million years ... new species discovered in the Greater Mekong Region of Southeast ... launched by World Wildlife Fund (WWF). First ... discovered or newly identified by science between 1997 and 2007 ...
... As the cold weather creeps in, so do brown ... a shy, reclusive spider looking for a warm home. Drawn ... want to stay away from humans. But, if care is ... one of ,the big three, according to a University of ...
... Calif.) While radiation treatments deliver precise doses ... spreading or to shrink tumors, oncologists have become ... neck cancer treatments to nerves responsible for upper ... nerve damage, UC Davis Cancer Center researchers have ...
Cached Biology News:Over 1,000 species discovered in the Greater Mekong in past decade 2Moving in for the winter toxic brown recluse spiders pose danger 2UC Davis team refines cancer treatments to reduce potential nerve damage 2
(Date:7/10/2014)... Senior supply chain management executives from over ... challenges of “Reducing Cost, Lead Time, & Defects in ... Describing the partnership of the Bio Supply Management Alliance ... ( SCMI) of the University of San Diego ... Kroc Institute of Peace and Justice in San Diego, ...
(Date:7/10/2014)... DALLAS , July 10, 2014  Kainos Capital, ... consumer brands, today announced that it has acquired the ... stake in the business. Terms of the transaction were ... loss and meal replacement business that markets ready-to-drink shakes, ... North America and in the ...
(Date:7/10/2014)... Calif., July 10, 2014   Ceres, Inc . ... seed company, announced today financial results for the three ... on its business. Ceres reported that the ... product performance this growing season in Brazil, which concluded ... the company,s sorghum evaluation areas for part of the ...
(Date:7/10/2014)... June 17, 2014 Using microscopic polymer light ... gases, researchers at MIT,s Quantum Photonics Laboratory have ... in the parts-per-billion range. Optical sensors are ideal ... high signal-to-noise ratio, compact, lightweight nature, and immunity ... sensors had been developed before, the MIT team ...
Breaking Biology Technology:Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4Kainos Capital Acquires Slim-Fast From Unilever 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9Swell new sensors 2
... , CARROLLTON, Ga., Sept. 10 ... studies show that only four percent of physician,s practices are using electronic ... Congressional Budget Office (CBO) estimates that by properly incentivizing physicians, health information ... EHRs will create rapid, real time reporting whereby potentially harmful ...
... NEW YORK, Sept. 10 David C. Galloway is recognized ... He provides Genealogy Consulting Services as well as Chemistry Laboratory ... David,s Genealogy Services Company has found much success due to ... David is responsible for all Analytical Proceedings as well as ...
... , , COLUMBIA, Md., Sept. 10 ... that develops and manufactures research and in vitro ... the appointment of the company,s president, Brad L. Stewart, ... Since joining Cylex as president in December 2007, ...
Cached Biology Technology:Greenway Medical Technologies Plays Leading Role in Interoperability Demonstrations at Seventh Annual Public Health Information Network (PHIN) Conference 2Greenway Medical Technologies Plays Leading Role in Interoperability Demonstrations at Seventh Annual Public Health Information Network (PHIN) Conference 3Greenway Medical Technologies Plays Leading Role in Interoperability Demonstrations at Seventh Annual Public Health Information Network (PHIN) Conference 4Continental Who's Who Executive Press Release: David C. Galloway 2Cylex, Inc. Appoints Brad L. Stewart as Chief Executive Officer and Chairman of the Board 2Cylex, Inc. Appoints Brad L. Stewart as Chief Executive Officer and Chairman of the Board 3Cylex, Inc. Appoints Brad L. Stewart as Chief Executive Officer and Chairman of the Board 4
... allows graphic manipulation of DNA sequences and ... award winning interface design that allows graphic ... providing sophisticated drawing capabilities for Mac and ... Plasmid Mapping Software" by the Biotechnology Software ...
... ISO 9001:2000 Certified USDA Research Registered ... SOP's Training AALAS Certified Technicians ... Procedures GLP Documentation Upon Request Focus ... point for all your custom immunology service ...
...
...
Biology Products: