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New diagnostic tool determines aggressiveness of prostate cancer
Date:4/25/2012

ick to the surface of the gold nanoparticles to form a protein corona. This corona can be detected by a technique called dynamic light scattering. Huo found that when cancer cells are present, they can "destroy" the IgG in the blood, and this specific interaction is picked up by the gold nanoparticles. Using this simple test, Huo can determine quantitatively how aggressive the prostate tumors are and the likelihood they will metastasize. The team tested out the technique on human tissue samples.

"We've had already done our study with animal and human blood samples," (J. Nanobiotechnology, http://www.jnanobiotechnology.com/content/9/1/20 ) Huo said. "Now we've confirmed our findings in both animal models and human tissue samples. I am in the process of conducting a validation study with the Florida Hospital Cancer Institute and I am very confidant the technology works."

If all goes well, clinical trials could begin in two to three years, and Huo hopes the diagnostic tool could be routinely used by physicians in as little as five years. The test most likely would be used to supplement those already used to provide doctors with more quantitative and accurate information, which could lead to more treatment options

The system that detects the reaction was discovered in Huo's lab four years ago. It's called "nanoparticle-enabled dynamic light scattering assay (NanoDLSay) and it is being used by many researchers around the world for everything from detecting cancer in blood to finding lead in water.

"We're looking for funding now to get to the next step," Huo said. The National Science Foundation and the Florida Department of Health Bankhead-Coley Foundation funded a lot of the basic research that went into creating the new technology.

"Ultimately it's about working together to help doctors help patients," Huo said. "That's why I research cancer. I want to help make that happen.
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Contact: Zenaida Gonzalez Kotala
zenaida.kotala@ucf.edu
407-823-6120
University of Central Florida
Source:Eurekalert  

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