Navigation Links
New diagnostic test for bladder cancer
Date:6/24/2010

Copenhagen, Denmark Researchers from the Danish Cancer Society and the Herlev University Hospital of Copenhagen have developed a novel assay to test for multiple tumor markers in bladder cancer. The related report by Serizawa et al, "Custom-designed MLPA using multiple short synthetic probes: application to methylation analysis of five promoter CpG islands in tumor and urine specimens from patients with bladder cancer," appears in the July 2010 issue of The Journal of Molecular Diagnostics.

Bladder cancer is the fourth most common type of cancer in men in the United States. Over 50,000 men are diagnosed with bladder cancer each year. Although early-stage superficial tumors can be shaved off or treated with BCG immunotherapy, late-stage patients with infiltrating tumor often require a cystectomy (removal of all or part of the bladder). Therefore, early diagnosis of bladder cancer is critical in maintaining lifestyle standards.

Methylation specific-multiplex ligation-dependent probe amplication (MS-MLPA) can be used to screen multiple target sequences simultaneously in a single reaction, allowing for rapid early screening of tumor markers. However, commercially available MS-MLPA kits are not available for many diseases, and custom probe design has been limited by problems of chemically synthesizing longer nucleotides. Researchers led by Dr. Per Guldberg of the Danish Cancer Society have now modified this assay by using multiple short synthetic probes to test for tumor markers in bladder cancer. They found that paired tumor and urine samples in most cases showed identical marker patterns, suggesting that this assay may be used for non-invasive diagnosis and disease monitoring.

Serizawa et al suggest that "the use of multiple short synthetic probes may provide a simple and cost-effective approach to custom-designed MLPA." In future studies, Dr. Guldberg's group will examine how "the same approach may be used for most other MLPA applications and thus provide the basis for a more widespread usage of the MLPA technology."


'/>"/>

Contact: Angela Colmone, Ph.D.
acolmone@asip.org
301-634-7953
American Journal of Pathology
Source:Eurekalert

Related biology news :

1. New chemically-sensitive MRI scan may bypass some invasive diagnostic tests in next decade
2. U of MN researchers discover noninvasive diagnostic tool for brain diseases
3. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
4. Smiths Detection to launch a portable diagnostic system for foot-and-mouth disease and avian flu
5. Arbor Vita rapid H5N1 flu diagnostic presented at ICEID meeting
6. First diagnostic test for Alzheimers and Parkinsons disease on the horizon
7. Fluorescent nano-barcodes could revolutionize diagnostics
8. New electrostatic-based DNA microarray technique could revolutionize medical diagnostics
9. AACR hosts Molecular Diagnostics in Cancer Therapeutic Development Meeting
10. Genetic Engineering & Biotechnology News reports on growing role of molecular diagnostics
11. European researchers harness unique properties of boron to develop new drugs and diagnostics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2017)... 8, 2017 About Voice Recognition Biometrics Voice ... it against a stored voiceprint template. Acoustic features ... and tone are compared to distinguish between individual ... as most PCs already have a microphone and ... recognition biometrics are most likely to be deployed ...
(Date:2/8/2017)... , Feb. 7, 2017 The biometrics ... by the confluence of organizations, desires to better ... knowledge-based systems (password and challenge questions), biometrics is ... government systems. The market is driven by use ... between consumer and enterprise uses cases, with consumer-facing ...
(Date:2/7/2017)... Feb. 7, 2017 Zimmer Biomet Holdings, Inc. ... healthcare, will present at the LEERINK Partners 6th Annual ... Hotel on Wednesday, February 15, 2017 at 10 a.m. ... the presentation can be accessed at http://wsw.com/webcast/leerink28/zbh .  ... conference via Zimmer Biomet,s Investor Relations website at ...
Breaking Biology News(10 mins):
(Date:2/22/2017)... VIRGINIA (PRWEB) , ... February 22, 2017 , ... ... today that Dr. Daniel Spyker, PhD, MD former Acting Deputy Director in the ... CDER’s Pilot Drug Evaluation Staff has joined the company as an Expert Consultant. ...
(Date:2/22/2017)... and SAN DIEGO ... Holdings (the "Company") (OTCQB:CELZ) announced today expansion of ... donor stem cell product through establishment of laboratory ... research activities at the San Diego BioLabs facility, ... Boehringer Ingelheim, Novartis, and Sanofi. In ...
(Date:2/21/2017)... Feb. 21, 2017 Synthetic Biologics, Inc. (NYSE ... the microbiome to protect and restore the health of patients, intends ... December 31, 2016 on Thursday, March 2, 2017, and to host ... dial-in information for the call is as follows: U.S. ... ...
(Date:2/21/2017)... ... February 21, 2017 , ... During ... connected digital health applications, announced a partnership with Redox, a leader in cloud-based ... to many clinical systems while keeping data secure in the cloud. , The ...
Breaking Biology Technology: