Navigation Links
New device promises safer way to deliver powerful drugs
Date:4/6/2011

College Park, Md. (April 6, 2011) -- A new drug delivery device designed and constructed by Jie Chen, Thomas Cesario and Peter Rentzepis promises to unlock the potential of photosensitive chemicals to kill drug-resistant infections and perhaps cancer tumors as well.

Photosensitive chemicals are molecules that release single oxygen atoms and chemical radicals when illuminated. These radicals are very active chemically, and can rip apart and destroy bacteria, said Peter Rentzepis, a professor of chemistry at University of California, Irvine.

Yet photosensitive chemicals are not approved for use in the United States, and used relatively rarely in Europe. This is because they are highly toxic and difficult to activate beneath the skin, since light only penetrates a few millimeters into the body.

Photosensitive chemicals also cause severe reactions, including headaches, nausea, and light sensitivity for 30 days. They kill healthy cells as well as bacteria. Although several have therapeutic potential, they are too toxic for human use by injection.

The researchers solved this problem with an optical fiber-based device that can deliver very small amounts of photosensitive chemicals to internal organs with pinpoint accuracy.

The device consists of three components. The first is an imaging component similar to the charge coupled devices (CCDs) in digital cameras. It enables a physician to guide the device to the infection.

A 1-millimeter-diameter flexible optical fiber attached micro sized high-power LED or laser diode provides the light for the CCD. Once the physician positions the device, the same light source shines with greater intensity to activate the medicine.

The third component is a hollow tube connected to a syringe of medicine to deliver the medicine to the infection. Rentzepis adds glycol, a thickening agent used in surgical soaps, to keep the medicine from spreading to healthy cells.

Pulling the syringe backwards creates a vacuum that sucks up any remaining chemical after the procedure.

"We can insert the instrument through the nose, bowels, mouth, or almost any opening and direct it where we want," Rentzepis said. "It lets us deliver very small amounts of these chemicals right to an infection or tumor, then remove them before they damage healthy cells."

The researchers plan to test the device on animals with infections and cancer.


'/>"/>

Contact: Charles Blue
cblue@aip.org
301-209-3091
American Institute of Physics
Source:Eurekalert

Related biology news :

1. University of Nevada, Reno invents next-gen device to track worlds air quality
2. MIT: New blood-testing device can quickly spot cancer cells, HIV
3. New device uses submarine technology to diagnose stroke quickly
4. UCLA Engineering advance with new nanomaterials good news for next-generation electronic devices
5. University of South Florida and Draper team to create advanced devices for testing malaria drugs
6. Armchair nanoribbons made into spintronic device
7. Simple, ingenious way to create lab-on-a-chip devices could become a model for teaching and research
8. Microfluidic device rapidly orients hundreds of embryos for high-throughput experiments
9. Simple rubber device mimics complex bird songs
10. Air flows in mechanical device reveal secrets of speech pathology
11. Study shows brass devices in plumbing systems can create serious lead-in-water problems
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/3/2016)... DUBLIN , Feb. 3, 2016 /PRNewswire/ ... announced the addition of the "Emotion ... NLP, Machine Learning, and Others), Software Tools ... Application Areas, End Users,and Regions - Global ... offering. --> http://www.researchandmarkets.com/research/d8zjcd/emotion_detection ) ...
(Date:2/2/2016)... 2016 This BCC Research report provides ... reviewing the recent advances in high throughput ‘omic ... field forward. Includes forecast through 2019. ... and opportunities that exist in the bioinformatic market. ... as well as IT and bioinformatics service providers. ...
(Date:2/2/2016)... 2016 Technology Enhancements Accelerate Growth of X-ray Imaging ... digital and computed radiography markets in Thailand ... Indonesia (TIM). It provides an in-depth ... well as regional market drivers and restraints. The study ... and market attractiveness, both for digital and computed radiography. ...
Breaking Biology News(10 mins):
(Date:2/4/2016)... 2016 Strasbourg, France , ... --> Strasbourg, France , to the US ... is pleased to announce that it acted as an advisor ... in Strasbourg, France , to the US ... --> Transgene (Euronext: TNG), a member of ...
(Date:2/3/2016)... 3, 2016  With the growing need for ... is underway, therapies such as monoclonal antibodies, recombinant ... host of indications are in high demand. Conventionally ... development and production of these therapeutics. However, due ... high costs, novel approaches and novel expression systems ...
(Date:2/3/2016)... ... February 03, 2016 , ... Aerocom, a world-leading supplier of ... North American healthcare market. , Aerocom Healthcare, LLC will be based in Denver, ... provide new pneumatic tube systems or expand existing systems within the U.S. and ...
(Date:2/3/2016)... Mass. , Feb. 3, 2016  Silk Therapeutics, Inc., ... financing round. Silk Therapeutics has now raised a total of ... made by the company. The Series A2 round was led ... Massachusetts , with participation from new investors Lear Corporation ... Sheri and Roy P. Disney ; Richard Sackler , ...
Breaking Biology Technology: