Navigation Links
New developments in reproductive medicine
Date:8/31/2009

Three out of ten women who undergo polar body diagnosis go on to have a child. The extensive technique of polar body analysis (PBA) is described by researchers in reproductive medicine at Lbeck in an article in the current edition of Deutsches rtzeblatt International, in which they present three successful cases and one failure (Dtsch Arztebl Int 2009; 106(33): 533-8).

Polar bodies are by-products of normal cell division (meiosis) of an oocytea woman's egg cellon its way to maturation. For people with monogenic diseases, which are caused by gene defects, polar body analysis can give an indication of whether the healthy version of the gene is present in the egg before fertilization takes place. Monogenic diseases, such as cystic fibrosis, are caused by an altera-tion of one gene; this makes them different from polygenic diseases, such as diabetes mellitus, for example, which are caused by a combination of defects in several genes.

In the cases of four women who were carriers of a monogenic disease, their own egg cells containing the intact version of the gene concerned were fertilized, allowed to develop to the embryonic stage, and then transferred into the womb. Three of the women had a successful pregnancy and gave birth to a healthy child. One woman failed to become pregnant, even after a further round of PBA fol-lowed by embryo transfer, and decided not to continue the treatment. These four cases are among nine couples tested using PBA at Lbeck by Georg Griesinger and his co-authors because of a known risk that the mother might transmit a monogenic disease.

In Germany PBA is an alternative to preimplantation diagnosis (PID), which depending on the result can lead to termination of pregnancy with all the associated psychological and physical stresses. The disadvantages of PBA are: hereditary diseases transmitted through the father cannot be diagnosed, and in the case of autosomal recessive diseases egg cells that would have resulted in the birth of healthy heterozygous carriers are discarded. In Germany, PBA for monogenic diseases is at present performed at only two centers, in Lbeck and Regensburg.


'/>"/>

Contact: E. Bartholomaeus
49-223-470-11133
Deutsches Aerzteblatt International
Source:Eurekalert

Related biology news :

1. Bovine genome provides clues to possible new developments
2. AACR annual meeting showcases developments in understanding and targeting cancers
3. Progress Against Malaria: Developments on the Horizon
4. 2 reproductive factors are important predictors of death from ovarian cancer
5. Plastics chemical retards growth, function of adult reproductive cells
6. Environmental cues control reproductive timing and longevity, University of Minnesota study shows
7. Stress puts double whammy on reproductive system, fertility
8. Recruitment of reproductive features into other cell types may underlie extended lifespan in animals
9. The importance of being helpful -- Cooperative cichlids boost their own reproductive success
10. Study: Health undervalued in reproductive rights debate
11. NIH funds research center for womens reproductive health at Einstein
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/3/2017)... WASHINGTON , April 3, 2017 /PRNewswire-USNewswire/ ... single-cell precision engineering platform, detected a statistically ... cell product prior to treatment and objective ... highlight the potential to predict whether cancer ... prior to treatment, as well as to ...
(Date:3/30/2017)... -- The research team of The Hong Kong Polytechnic ... by adopting ground breaking 3D fingerprint minutiae recovery and matching technology, ... accuracy for use in identification, crime investigation, immigration control, security of ... ... A research team led by Dr ...
(Date:3/29/2017)... 29, 2017  higi, the health IT company that ... North America , today announced a Series B ... of EveryMove. The new investment and acquisition accelerates higi,s ... to transform population health activities through the collection and ... higi collects and secures data today on behalf ...
Breaking Biology News(10 mins):
(Date:4/21/2017)... ... April 21, 2017 , ... ... to nourishing a range of emerging bio and technology start-ups, is hosting “Celebration ... 2017. This double event will start with libations and networking at 3:30 p.m. ...
(Date:4/20/2017)... ... April 20, 2017 , ... ... new webinar will explore challenging patient cases when screening for direct oral anticoagulant. ... may be a need for bridging parental anticoagulation especially for those at high ...
(Date:4/20/2017)... 2017  Eli Lilly and Company (NYSE: ... for the prevention of migraine at the American Academy ... April 22-28, 2017, in Boston . ... AAN, including safety and patient outcomes data for galcanezumab ... reduction in monthly migraine headache days among patients with ...
(Date:4/20/2017)... ... April 20, 2017 , ... ... scientific and clinical research community’s growing body of knowledge during its Eighth ... Gracie Theatre and the adjacent Darling Atrium. During the event, undergraduates, graduate students, ...
Breaking Biology Technology: