Navigation Links
New data on the regulation of a protein that is altered in all cancers
Date:4/20/2010

This release is available in Spanish.

In all cancers, whether in kidney, breast, lung, colon, skin or any other tissue, cells show high Myc protein levels. Excess Myc causes cells to multiply in an exaggerated manner, giving rise to the development of tumours. One of the most pressing questions about Myc is how healthy cells keep the expression of this protein in check. In a study using the Drosophila, researchers at the Institute for Research in Biomedicine (IRB Barcelona) headed by ICREA scientist Marco Miln have discovered that the microRNA machinery controls the levels of Myc through the molecule Mei-P26, thereby conferring microRNAs unexpected importance. The study is published this week in EMBO Journal, a scientific journal of high impact in basic biomedical research that belongs to the Nature group.

MicroRNAs (miRNAs) are small molecules that account for less than 1% of the human genome; however, they play a key role in cell function because they have the capacity to disable or modify a great number of genes. High levels of certain miRNAs cause cancer. In previous studies conducted in mice, it was demonstrated that the Myc protein controls the expression levels of miRNAs. Now scientists have discovered in Drosophila that miRNAs affect the levels of Myc. "We propose that there is a finely tuned mechanism by which miRNAs and Myc are mutually controlled", explains Miln. The researchers suggest that the cell uses this mechanism to maintain optimal levels of miRNA and Myc, indispensable for the proper functioning of the organism, while preventing their becoming dangerous.

Mei-P26, the key component

The researchers discovered this new regulatory mechanism by removing Drosophila's 150 miRNAs from a developing wing. Without miRNAs, they obtained a tissue with similar characteristics to that attained when Myc is removed: the wing is smaller and the cells are also smaller and do not divide well. "Myc is like an orchestra conductor that guides the growth of tissue, including healthy tissue, and since the wing characteristics in both cases were similar, we thought that the miRNAs and Myc were related; and we were right", explains Hctor Herranz, post-doc researcher fellow in Milan's lab and first author of the article.

The dissection of the molecular mechanism revealed that the key piece in the regulation of Myc by miRNAs is Mei-P26, a molecule known to target Myc in mice. Cells lacking miRNAs show increased Mei-P26 levels and decreased Myc expression. "We have closed the circle of this regulatory mechanism, positioning the miRNAs in the diagram".

Given that miRNAs, Mei-p26 and Myc have homologues in mice and humans, and alterations in the expression of these homologues cause tumours, the researchers propose that this same regulatory mechanism of Myc could be present in higher organisms. Confirmation of this notion would open up new avenues in the study of cancer.


'/>"/>

Contact: Sonia Armengou
sonia.armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)
Source:Eurekalert  

Related biology news :

1. Rewiring of gene regulation across 300 million years of evolution
2. Gene regulation: Can we stomach it?
3. High-throughput analysis of gene regulation, DNA synthesis in Cold Spring Harbor Protocols
4. Linheng Li proposes novel theory for mammalian stem cell regulation
5. $1 million from NIH continues cell growth regulation studies
6. New research into the mechanisms of gene regulation
7. Trans fats hinder multiple steps in blood flow regulation pathways
8. The evolution of gene regulation
9. Regulation of cell proliferation by the OGF-OGFr axis is dependent on nuclear localization signals
10. A paradigm shift in immune response regulation
11. Unclear regulations obstacle to biological diversity
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New data on the regulation of a protein that is altered in all cancers
(Date:3/23/2017)... , March 23, 2017 The report "Gesture Recognition ... Biometric), Industry, and Geography - Global Forecast to 2022", published by MarketsandMarkets, the ... a CAGR of 29.63% between 2017 and 2022. ... ... ...
(Date:3/22/2017)... Calif. , March 21, 2017 ... analytics company serving law enforcement agencies, announced today the ... as director of public safety business development. ... diversified law enforcement experience, including a focus on the ... In his most recent position, Mr. Sheridan served as ...
(Date:3/13/2017)... 2017 Future of security: Biometric Face Matching software  ... ... DERMALOGs Face Matching enables to match face pictures against each other or ... individuals. (PRNewsFoto/Dermalog Identification Systems) ... "Face Matching" is the fastest software for biometric Face Matching on the market. ...
Breaking Biology News(10 mins):
(Date:4/26/2017)... Palo Alto, CA, USA (PRWEB) , ... April ... ... ComplianceOnline’s popular seminar on FDA’s GMP expectations for phase I clinical trials comes ... was attended by various biotechnology and pharma professionals representing FDA regulated organizations such ...
(Date:4/26/2017)... ... April 26, 2017 , ... Baltimore bio tech ... mail security screening solution at the National Postal Forum 2017 in Baltimore, Maryland, ... fast, highly accurate, easy to use and low cost threat detection solution for ...
(Date:4/26/2017)... (PRWEB) , ... April 26, 2017 , ... ... headlines and drive high-level conversations among healthcare industry stakeholders, the discussion surrounding the ... – taking place May 15-18, 2017 in Los Angeles, Calif. Hosted by the ...
(Date:4/25/2017)... Ca (PRWEB) , ... April 25, 2017 , ... As ... in the series will explore the laboratory testing for DIC in order to illuminate ... hypercoagulable disorder which can occur in hospitalized patients resulting in a high degree of ...
Breaking Biology Technology: