Navigation Links
New data on islet autoantibodies in young children defines early type 1 diabetes development
Date:6/19/2013

New York, NY, June 19, 2013 A decade-long JDRF-funded study led by the Institute of Diabetes Research in Helmholtz Zentrum Mnchen, Germany, is providing a deeper understanding of the link between autoantibodies and the risk of developing type 1 diabetes (T1D), highlighting the importance of pre-diabetes research into possible preventions for the disease. The study, "Seroconversion to Multiple Islet Autoantibodies and Risk of Progression to Diabetes in Children," was published today in The Journal of the American Medical Association.

Researchers in Colorado (DAISY study), Finland (DIPP study), and Germany (BABYDIAB) followed children from infancy until as old as three years old, to determine the presence of islet autoantibodiesmarkers that indicate the activation of the autoimmune attack on insulin-producing beta cells in the pancreas. T1D occurs when these beta cells are destroyed, rendering people with the disease unable to produce their own insulin. The new findings reveal that nearly 70 percent of the 585 young children studied (in all three countries) who had two or more autoantibodies developed T1D within 10 years, with 84 percent developing T1D in 15 years. The study also revealed that 14.5 percent of the 474 children with a single islet autoantibody developed T1D within 10 years, and that progression of the disease was faster for those who showed the presence of antibodies at younger than three years old. The risk for children without autoantibodies was only 0.4 percent by age 15 years.

"This is the first true estimate from when we think the process of type 1 diabetes starts, and the largest dataset that exists, with over 13,000 children followed from birth and over 1,000 children who developed antibodies," said Anette-Gabriele Ziegler, M.D., director of the Institute of Diabetes Research, who led the study in Germany. "I believe that this sort of data should make us consider whether the status of confirmed multiple islet autoan
'/>"/>

Contact: Tara Wilcox-Ghanoonparvar
twilcox-ghanoonparvar@jdrf.org
212-479-7524
JDRF
Source:Eurekalert

Page: 1 2

Related biology news :

1. Cell Transplantation reports islet cell advancement increases impact on transplantation
2. Some factors that impact islet transplantation explored in Cell Transplantation papers
3. Some factors that impact islet transplantation explored in Cell Transplantation papers
4. Flu vaccines aimed at younger populations could break annual transmission cycle
5. Peihua Jiang receives Ajinomoto Award for Young Investigators in Gustation from AChemS
6. Birds find ways to avoid raising cuckoos young
7. Teen mentors inspire healthier choices in younger children
8. Risk management in fish: How cichlids prevent their young from being eaten
9. Fruit flies force their young to drink alcohol -- for their own good
10. Young malaria parasites refuse to take their medicine, may explain emerging drug resistance
11. Experimental gene therapy treatment for Duchenne muscular dystrophy offers hope for youngster
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2014)... WINSTON SALEM, N.C. , Dec. 10, 2014  That blood ... for quite a while. Hypertension – the medical term for ... in the early 1800s, and the inflatable cuff that,s used ... That doesn,t, however, mean there,s nothing new about hypertension, its ...
(Date:12/10/2014)... 8, 2014 You,ve been here before: you desperately need to ... site key or the answer to your secret question. What,s your ... Today, Hoyos Labs , a digital infrastructure security company, launches ... the frustration that comes with usernames, passwords and PINs – ...
(Date:12/10/2014)... 2014  Wake Forest Baptist Medical Center today announced plans for ... Funding for this $50 million capital project is part of ... summer. The medical education building will be ... complex, adjacent to 525@vine in Wake Forest Innovation Quarter. Construction ...
Breaking Biology News(10 mins):Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4
... 2008 Changing the sugars attached to a hormone produced ... 50 percent, a research group at Washington University School of ... alter a reproductive "thermostat," unveiling part of an intricate regulatory ... fertility. "To adjust for the right amount of key ...
... PHILADELPHIA, May 16, 2008 New data show that ... painful oral mucositis (OM) and improves quality of life ... These data will be reported in two separate presentations, ... tomorrow as a poster session, at the 33rd Annual ...
... of Forest Research presents the preliminary findings of ... landscape-scale experiments on how forest management affects western ... Research team includes U.S. Forest Service, Humboldt State ... Georgia and Wildlife Conservation Society scientists collaborating in ...
Cached Biology News:Disabling mouse enzyme increases fertility 2CAPHOSOL relieves oral mucositis and improves quality-of-life in cancer patients 2CAPHOSOL relieves oral mucositis and improves quality-of-life in cancer patients 3CAPHOSOL relieves oral mucositis and improves quality-of-life in cancer patients 4Pioneering landscape-scale research releases first findings 2
(Date:1/22/2015)... January 22, 2015 Dr. Greg Leyer of ... annual Scripps Natural Supplements Pre-Conference seminar on probiotics in San ... an annual continuing education conference for health care professionals. This ... the topic of probiotics in health. Dr. Leyer spoke about ...
(Date:1/22/2015)... DIEGO , Jan. 22, 2015   Cypher ... and Sequenom, Inc. (NASDAQ: SQNM ), ... development agreement for next generation noninvasive prenatal tests ... genome interpretation technology, called Mantis™, to advance analysis ...
(Date:12/24/2014)... 24, 2014  United Therapeutics Corporation (NASDAQ: UTHR ... MDT ) has submitted a pre-market approval application to ... use of Medtronic,s SynchroMed ® II implantable drug ... with United Therapeutics, Remodulin ® (treprostinil) Injection delivered ...
(Date:12/24/2014)... Louis, Missouri (PRWEB) December 23, 2014 GMO ... biotechnology company, Syngenta, are in the process of being consolidated ... case is In Re: Syngenta AG MIR 162 Corn Litigation, ... District of Kansas. , Management of the Syngenta GMO corn ...
Breaking Biology Technology:Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2
... Odenheim, director of IT services at Synteract, Inc., ... on Selecting the Optimum EDC Platform to Support your ... East Coast conference , to be held in Philadelphia, March ... March 28, discussing a variety of drivers to consider when ...
... capacitors (ECs), also known as supercapacitors or ultracapacitors, differ ... TV or computer in that they store substantially higher ... storage devices as they charge and discharge faster than ... densities, only a fraction of the energy density of ...
... 2012 Sigma-Aldrich® Corporation (NASDAQ: SIAL ) ... Wuxi, China, that will provide localized packaging, analytical services ... Company,s research and industrial customers in the region. ... in industrial growth, and now we are viewing a ...
Cached Biology Technology:Synteract Director of IT Services Toby Odenheim Speaking at March 2012 Outsourcing in Clinical Trials East Coast Conference 2Synteract Director of IT Services Toby Odenheim Speaking at March 2012 Outsourcing in Clinical Trials East Coast Conference 3Researchers develop graphene supercapacitor holding promise for portable electronics 2Researchers develop graphene supercapacitor holding promise for portable electronics 3Researchers develop graphene supercapacitor holding promise for portable electronics 4Sigma-Aldrich Opens New Wuxi Packaging and Quality Control Facilities to Enhance Capabilities Serving China and Asia-Pacific Region 2Sigma-Aldrich Opens New Wuxi Packaging and Quality Control Facilities to Enhance Capabilities Serving China and Asia-Pacific Region 3
... and pathophysiological stressful conditions trigger the synthesis ... heat shock proteins (HSPs), more appropriately called ... Hsp90 family of proteins in mammalian cells ... and Trap-1 (Hsp75). It was found that ...
Custom LNA Oligonucleotide synthesis ,High quality Custom LNA Oligonucleotides are available for a variety of different specialty applications and innovative products. ,Please inquire for further...
... SOS Protein Solubility Service, We ... , New SOS technology yields the best ... parameters applied on each clone submitted , ... ,The new protein Solubility Optimization Service ...
... proteomic scale kinase profiling, quantitative measurement ... discovery research built on the flexible ... platform. These microarrays are available as ... Substrate - Peptide Microarray Service. ...
Biology Products: