Navigation Links
New data on highly effective treatment for chronic rhinosinusitis with nasal polyps

December 1, 2009: OptiNose is pleased to announce the publication of results from its Phase II clinical study investigating the efficacy and tolerability of its novel, intranasal drug/device product for the topical treatment of chronic rhinosinusitis with nasal polyps in Rhinology, the official journal of the International and European Rhinologic Societies.

Chronic rhinosinusitis with nasal polyps is a chronic disease that can significantly reduce a patient's quality of life, causing facial pressure and pain, nasal obstruction and reduced sense of smell. The novel OptiNose device delivers drugs to target sites deep in the nose, including the sinus openings where nasal polyps emerge. These targets are often difficult to reach with traditional nasal sprays.

In the Phase II study conducted by OptiNose, patients in the active treatment group experienced highly significant reductions in polyp size compared to placebo with corresponding significant and progressive improvements of all symptom scores including rhinitis symptoms, nasal discomfort and sense of smell. At the conclusion of the study, the polyps had disappeared in 10 out of 54 patients in the active group, whereas polyps were still present in all patients in the control group.

The multicenter, placebo-controlled study, conducted in 109 patients with mild-to-moderate bilateral nasal polyposis, assessed the efficacy, safety and tolerability of 400 micrograms of fluticasone propionate delivered twice daily with OptiNose's liquid nasal drug delivery device over a 12 week period. Reduction in polyp size was measured using Lildholdt's Scale, a 4-point scale used to rate the size of nasal polyps. A significantly greater percentage of subjects using the OptiNose product showed a reduction in polyp size greater than or equal to 1 on the Lildholdt's Scale when compared to placebo at 4, 8 and 12 weeks (22% vs 7%, p = 0.011; 43% vs 7%, p < 0.001; 57% vs 9%, p < 0.001). The summed polyp score was reduced by 35% in the OptiNose treatment group after 12 weeks, compared to an increase in polyp score in the placebo group (-0.98 vs +0.23, p < 0.001). The peak nasal inspiratory airflow (PNIF) of subjects in the active group increased progressively during treatment (p < 0.001) and 76% of subjects treated were improved or very much improved after 12 weeks of treatment (p < 0.001).

"We are extremely pleased with these results", said ENT-specialist Per Djupesland, M.D., Ph.D., the study's co-author and Chief Scientific Officer at OptiNose AS. "This disease is difficult to treat and often recurs, even after repeated surgeries. Existing medical treatments offer only limited efficacy, especially on small and moderate sized polyps which are difficult to reach. The progressive reduction of small and moderate polyps in our study, including the complete removal in almost 20% of patients is particularly encouraging."

Chronic rhinosinusitis with nasal polyps is a common disease, severely reducing a patient's quality of life, with few effective treatments currently available. It is estimated that as much 10% of the population is affected by chronic rhinosinusitis, making it one of the most common chronic diseases. A substantial proportion (25-30%) of these patients suffer from nasal polyps and many undergo repeated costly surgeries. Improved medical treatment can reduce or eliminate the need for surgery. Furthermore, up to 50% of patients with nasal polyps suffer from asthma. Optimal treatment of chronic rhinosinusitis and nasal polyps can improve asthma symptoms and reduce the need for asthma medication.


Contact: Helena Djupesland
WFD Ventures

Related biology news :

1. Scientists unravel evolution of highly toxic box jellyfish
2. LMU Munich researchers highly endowed with EU funding
3. Forsyth receives highly competitive challenge grants
4. Duke biomedical scientists win 2 highly prized NIH Directors Awards
5. Lancet study supports new, highly effective treatment for blood disorder
6. New population of highly threatened greater bamboo lemur found in Madagascar
7. Slow-motion video study shows shrews are highly sophisticated predators
8. The key to unlocking the secret of highly specific DNAzyme catalysis
9. 454 Sequencing: Science paper describes a novel, highly efficient method of sequencing ancient DNA
10. A sticky solution for identifying effective probiotics
11. Carnegie Mellon customizing electric cars for cost-effective urban commuting
Post Your Comments:
(Date:6/20/2016)... 20, 2016 Securus Technologies, a leading ... for public safety, investigation, corrections and monitoring announced ... it has secured the final acceptance by all ... Managed Access Systems (MAS) installed. Furthermore, Securus will ... be installed by October, 2016. MAS distinguishes between ...
(Date:6/15/2016)... ALBANY, New York , June 15, 2016 ... published a new market report titled "Gesture Recognition Market ... Trends and Forecast, 2016 - 2024". According to the ... at USD 11.60 billion in 2015 and is ... and reach USD 48.56 billion by 2024.  ...
(Date:6/9/2016)... Finland , June 9, 2016 ... National Police deploy Teleste,s video security solution to ensure the ... France during the major tournament ... data communications systems and services, announced today that its video ... Prefecture to back up public safety across the ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... (PRWEB) , ... June 27, 2016 , ... ... published their findings on what they believe could be a new and helpful ... the new research. Click here to read it now. , Biomarkers ...
(Date:6/27/2016)... 27, 2016  Liquid Biotech USA ... of a Sponsored Research Agreement with The University ... (CTCs) from cancer patients.  The funding will be ... correlate with clinical outcomes in cancer patients undergoing ... then be employed to support the design of ...
(Date:6/24/2016)... ... , ... While the majority of commercial spectrophotometers and fluorometers use the z-dimension ... are higher end machines that use the more unconventional z-dimension of 20mm. Z-dimension ... bottom of the cuvette holder. , FireflySci has developed several Agilent flow cell ...
(Date:6/23/2016)... 23, 2016   Boston Biomedical , an ... designed to target cancer stemness pathways, announced that ... Orphan Drug Designation from the U.S. Food and ... cancer, including gastroesophageal junction (GEJ) cancer. Napabucasin is ... inhibit cancer stemness pathways by targeting STAT3, and ...
Breaking Biology Technology: