"Mucin-1 could be a promising target in future cancer therapy," Dr Sinn added. "Agents that stimulate the patient's immune system to attack cells carrying mucin-1 are currently being tested in clinical trials. Determination of mucin-1 by the methods we described in our study may help to select patients that are likely to benefit from such a therapy."
Gene index predicts response to endocrine therapy
Researchers from Germany and the US have confirmed that a 165-gene index can predict survival among breast cancer patients who are treated with endocrine therapies in combination with surgery.
The Sensitivity to Endocrine Therapy (SET) index has been reported in the past to predict survival benefit from adjuvant endocrine therapy, independently of prognosis. In the new study, Dr Thomas Karn from Goethe University in Frankfurt and colleagues set up a blinded study to prospectively validate the index's ability to predict survival in an unpublished retrospective cohort of 307 estrogen-receptor positive primary breast cancers treated solely with endocrine therapy.
Dr Karn and colleagues provided gene expression profiles from 261 patients to the developers of SET without any clinical information. The latters then categorized them into classes based on published pre-specified cutoffs.
Once the analysis had been completed, Dr Karn's group analyzed the relationships between the SET classifications and clinical outcomes for the patients.
They found that patients in the low, intermediate and high SET classes did not differ in age, tumor size, lymph node or HER2 status. However, lower SET significantly correlated with higher grade tumors and negative progesterone-receptor status.
"In the lymph node negative cohort we obse
|Contact: Vanessa Pavinato|
European Society for Medical Oncology