Navigation Links
New data improve understanding of breast cancer's multiple varieties
Date:5/3/2012

"

A marker for response to neoadjuvant anthracycline/taxane chemotherapy

Breast cancers that express low levels of the protein mucin-1 tend to respond better to pre-surgical chemotherapy with anthracyclines and taxanes, say German researchers.

Dr Bruno Sinn from Charit Universittsmedizin Berlin and colleagues from the German Breast Group set out to evaluate how many breast cancers express the gene MUC1, and whether expression of this gene could help predict response and survival after neoadjuvant anthracycline/taxane-based chemotherapy.

"Mucins are present on the internal surface of different organs throughout the body, including the gastrointestinal tract, the lungs and the breast glands," Dr Sinn explained. "In healthy tissues, their role is mainly to protect and to lubricate these surfaces. Mucins, among them mucin-1, have also been shown to be very frequently and abundantly present in tumor cells like breast cancer cells. In cancer, mucin-1 is often present in an altered form and in abnormal locations of the cell. In laboratory experiments, it has been shown that mucin-1 interacts with several cellular signaling networks that may contribute to the malignant behavior of the cells." Interestingly, it is also known that mucin-1 plays a role in the interaction of tumor cells with the immune system of the patient. Abnormal mucin-1 on cancer cells may serve as an antigen that helps to induce the patient's immune system to attack and remove these cells.

The researchers studied tumor biopsy samples from a previous clinical trial of the German Breast Group. In 691 samples, they tested for the presence of the MUC1 protein, and in 268 they explored expression of messenger RNA for the gene. They could detect MUC1 in 656 (95%) cases, and the level of mRNA for the gene varied 1000-fold between tumors.

"High MUC1 protein and mRNA expression were seen more frequently in hormone-receptor positive tumors," Dr Sinn sa
'/>"/>

Contact: Vanessa Pavinato
media@esmo.org
European Society for Medical Oncology
Source:Eurekalert

Page: 1 2 3 4 5 6

Related biology news :

1. FSU joins coalition working to improve nations power grid
2. For insulin sensitive overweight patients, 1 session of exercise improves metabolic health
3. NIH awards Clemson bioengineer $1.5 million to improve durability of tissue heart valves
4. Researchers study how pistachios may improve heart health
5. Scientists identify gene that may contribute to improved rice yield
6. Research about plant viruses could lead to new ways to improve crop yields
7. RNA molecules, delivery system improve vaccine responses, effectiveness
8. British scientists go cloud-hopping in the Pacific to improve climate predictions
9. How eating fruit and vegetables can improve cancer patients response to chemotherapy
10. USAID grant awarded to improve food security in Africa
11. UI researchers help to improve carbon measurements in global climate studies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... , Dec. 15, 2014 The Defense ... it easier to detect and prevent counterfeit microcircuits ... Today the agency started performing an in-house microcircuit ... validate the authenticity of purchased microcircuits while increasing ... quality control measures will be conducted at DLA,s ...
(Date:12/17/2014)... , Dec. 16, 2014  Automation is ... this more evident than at international borders. Over ... document scanners have allowed veteran travelers to self ... Passport Control (APC) Kiosks at an increasing number ... globe. According to Maxine ...
(Date:12/11/2014)... WINSTON SALEM, N.C. , Dec. 10, 2014  That ... known for quite a while. Hypertension – the medical term ... disease in the early 1800s, and the inflatable cuff that,s ... That doesn,t, however, mean there,s nothing new about hypertension, ... punctured some long-held beliefs about the condition and the best ...
Breaking Biology News(10 mins):Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4
... Researchers at North Carolina State University have developed ... with biological systems including the human body. Their ... environmental safety in the handling of nanomaterials, as well ... Dr. Jim Riviere, Burroughs Wellcome Distinguished Professor of ...
... Board: http://photos.prnewswire.com/prnh/20050509/BIOKEYLOGO ) (Logo: http://www.newscom.com/cgi-bin/prnh//20050509/BIOKEYLOGO ) , ... BIO-key International, Inc. Second Quarter 2010 Conference Call , ... - 10:00 a.m. Eastern Time , ... asking for the BIO-key call at least 10 minutes prior to the ...
... the following schedule and contact information for a teleconference on financial results through the second quarter ... Monday, August 16, 2010 , ... Vice President, Investor Relations , ... London: 0800-279-9630 , Netherlands: ...
Cached Biology News:Probing the nanoparticle: Predicting how nanoparticles will react in the human body 2BIO-key® Announces Second Quarter 2010 Earnings Release and Conference Call Schedule 2BIO-key® Announces Second Quarter 2010 Earnings Release and Conference Call Schedule 3Teleconference Alert: LyondellBasell Reviews Second Quarter 2010 Financial Results 2
(Date:12/22/2014)... 22, 2014 Fertility Associates of Memphis ... Bank USA , a network of more than 20 ... partnership, patients have fast access to a national pool ... IVF . Fertility Associates of Memphis is the only ... treatment option. , Dr. William Kutteh , director ...
(Date:12/19/2014)... December 19, 2014 BioPlus Specialty ... pharmacies, announces the promotion of Nick Maroulis, Pharm.D. to ... Pharmacy Services. , In this position, Dr. Maroulis ... also managing the directors of our multi-site pharmacies as ... since 1997 and during that time he has served ...
(Date:12/19/2014)... Calif. , Dec. 19, 2014 Bina Technologies, ... USA) announced today that they have been acquired by ... is a privately held company that provides a ... next generation sequencing (NGS) data for the academic and ... Roche Sequencing Unit, and will continue to focus on ...
(Date:12/19/2014)... FL (PRWEB) December 18, 2014 ... the nation’s leading specialty pharmacies, has an expanded ... as clinical pharmacy consultants for prescriber offices in ... expertise. , “We have a variety of ... For example, those specializing in hepatitis C help ...
Breaking Biology Technology:Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3BioPlus Specialty Pharmacy Expands ‘Regional Pharmaceutical Care Liaison’ Team 2BioPlus Specialty Pharmacy Expands ‘Regional Pharmaceutical Care Liaison’ Team 3
... Feb. 14, 2012 Avaxia Biologics, Inc., a ... act locally within the gastrointestinal tract, announced today ... A angel-led financing.  Cherrystone Angels of Providence, Rhode ... Angels, Boston Harbor Angels, Launchpad Venture Group, Mass ...
... 13, 2012  Ten years ago today, a task force ... together to develop a strategy for Indiana,s life sciences ... life sciences companies and research institutions into a 21st-century ... BioCrossroads, that strategy has driven the state into the ...
... 13, 2012 Amgen (NASDAQ: AMGN ) will present ... Eastern Standard Time  on Thursday, Feb. 16, 2012, at the ... executive vice president and chief financial officer at Amgen, will ... be accessed from the Events Calendar on Amgen,s website, ...
Cached Biology Technology:Avaxia Biologics, Inc. Closes $4.1 Million Series A Financing to Advance Oral Antibodies for Inflammatory Bowel Disease 2Avaxia Biologics, Inc. Closes $4.1 Million Series A Financing to Advance Oral Antibodies for Inflammatory Bowel Disease 3BioCrossroads Commemorates Decade of Collaboration, Success for Indiana Life Sciences Sector 2BioCrossroads Commemorates Decade of Collaboration, Success for Indiana Life Sciences Sector 3
Custom LNA Oligonucleotide synthesis ,High quality Custom LNA Oligonucleotides are available for a variety of different specialty applications and innovative products. ,Please inquire for further...
... 'Agilents GeneSpring Workgroup solution is ... managing and mining expression data in ... and is deployed in over 40 ... research organizations worldwide. GeneSpring Workgroup streamlines ...
... Western blotting is a commonly used ... Typically, protein samples are electrophoresed on SDS-PAGE ... nitrocellulose or nylon, where they are probed ... technologies, which allow reuse of Southern and ...
... for quantitative assays using recombinant proteins/antibodies ... the flexible and powerful Paraflo microfluidic ... sequences can be synthesized on-chip and ... custom sequence design. These microarrays are ...
Biology Products: