Navigation Links
New data improve understanding of breast cancer's multiple varieties
Date:5/3/2012

stimuli.

To clarify this issue, they used a genetic mechanism to block the AP-1 pathway in mice and cell culture. The researchers report that inhibiting AP-1 enhanced the effects of tamoxifen and delayed the development of tamoxifen resistance. Their data suggest that specific drugs with 'AP-1 inhibitory' effects might be useful in combination with available endocrine agents to develop new, more efficacious treatments.

"Fully understanding the biology behind endocrine resistance is the first step to design new drugs. I think that our data represent such a step forward," Dr Malorni said. "At the same time, our data might be helpful in deriving new biomarkers that could identify patients at higher risk of developing endocrine resistance. This might be an important contribution as today we are able to only partially predict response to endocrine treatment with the available biomarkers."

The researchers propose that endocrine resistance develops when the estrogen receptor 'switches' from its classical direct binding to specific estrogen responsive elements in the tumor genome, to an indirect DNA binding program via AP-1.

"In this light, AP-1 cooperation with estrogen receptor might be considered as a fundamental feature of the endocrine-resistant breast cancer cell. We cannot exclude, however, that AP-1 activity independently of ER is also important. More studies are needed to dissect these different mechanisms," Dr Malorni said.

"I hope that our data could stimulate researchers in this field to consider in their studies the 'switch' in estrogen receptor activity that we are proposing," the researcher added. "For instance, common techniques to evaluate estrogen receptor activity in vitro rely only on measurements of ERE-related functions. Our data suggest that this might be an incomplete view that needs to be implemented with measurements of other estrogen receptor functions as well, such as those that are related to AP-1.
'/>"/>

Contact: Vanessa Pavinato
media@esmo.org
European Society for Medical Oncology
Source:Eurekalert

Page: 1 2 3 4 5 6

Related biology news :

1. FSU joins coalition working to improve nations power grid
2. For insulin sensitive overweight patients, 1 session of exercise improves metabolic health
3. NIH awards Clemson bioengineer $1.5 million to improve durability of tissue heart valves
4. Researchers study how pistachios may improve heart health
5. Scientists identify gene that may contribute to improved rice yield
6. Research about plant viruses could lead to new ways to improve crop yields
7. RNA molecules, delivery system improve vaccine responses, effectiveness
8. British scientists go cloud-hopping in the Pacific to improve climate predictions
9. How eating fruit and vegetables can improve cancer patients response to chemotherapy
10. USAID grant awarded to improve food security in Africa
11. UI researchers help to improve carbon measurements in global climate studies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... climate change shifts the geographic ranges in which animals ... has on their parasites. Does an increased range for ... well? , Not necessarily, says a team of UC ... Kuris. In a study published in the Journal ... for some species, the opposite may happen: Hosts may ...
(Date:7/9/2014)... NY, July 9, 2014Biofuels derived from the oils produced ... fossil fuels. To achieve this goal, optimization of cost ... open pond systems, is needed. Sapphire Energy has developed ... open pond algae cultivation systems, described in Industrial ... Inc., publishers. The article is available on the ...
(Date:7/9/2014)... URBANA, Ill. With over 100 diseases that can ... the top of the most wanted list? University of ... reason that more research is needed on the fungus ... associated with cool, damp growing conditions but Macrophomina ... hot and dry drought conditions. , "As the climate ...
Breaking Biology News(10 mins):Not at home on the range 2Not at home on the range 3Not at home on the range 4Controlling contamination in open algae ponds for biofuels 2Climate change provides good growing conditions for charcoal rot in soybeans 2Climate change provides good growing conditions for charcoal rot in soybeans 3
... of how an abundance of fossils have been marvellously preserved ... of Africa has been solved by a team of geologists ... have established that an ancient wind brought life to the ... the dead. Sarah Gabbott, Jan Zalasiewicz and colleagues investigated ...
... a strategic alliance for catalysis research, "Munich Catalysis." In addition ... aspect of this cooperation will be the development of innovative ... global demand for energy and base chemicals on a long-term ... to two million euros a year. The cooperation is based ...
... The Great Tit is a common garden bird of many ... thought of as fairly inquisitive but it has long been ... surroundings. Some birds known as "fast" or "proactive" ... or "reactive" birds are more cautious. The differences are ...
Cached Biology News:Up to 20 million euros for Munich Catalysis research cooperation 2Up to 20 million euros for Munich Catalysis research cooperation 3Bird-brained? Birds' personalities are correlated with their hormone levels 2
(Date:1/15/2014)... 15, 2014 TaiGen Biotechnology Company, Limited ("TaiGen") today ... R-Pharm, a leading Russian pharmaceutical company, to develop and ... Russian Federation , Turkey ... is a novel antibiotic for the treatment of bacterial ...
(Date:1/14/2014)... 2014  3D Communications, a leading provider of strategic communications services to ... events in the United States and ... Cox , JD, is returning to the firm,s Washington, ... 3D after more than two years of service as Associate Commissioner ...
(Date:1/14/2014)... SAN DIEGO and BETHESDA, Md. ... they are joining together with two institutes from the ... more reliable tools for bringing safer, more effective treatments ... with the National Center for Advancing Translational Sciences (NCATS) ...
(Date:1/14/2014)... Rockville, MD (PRWEB) January 14, 2014 ... dedicated to developing innovative information technology solutions for ... other health care stakeholders, announced today the signing ... the US Food and Drug Administration (FDA). ...
Breaking Biology Technology:TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4Former FDA Associate Commissioner Returns To 3D Communications 2Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3Global Record Systems Announces Research Collaboration Agreement with FDA to Create a Novel “Big Data” Paradigm for Collection of Patient Safety and Outcomes Information 2
... previously reported, communicated in late 2007 ... ... Biotech Products, L.P.,today modified prescribing information for PROCRIT(R) (Epoetin alfa),following guidance from ... within the erythropoiesis-stimulating agent,(ESA) class., Modifications to the label were based ...
... by the Environmental Protection Agency (EPA) to fine California ... nano-pesticides is being applauded by David Rejeski, the director ... should receive a big pat on the back for ... federal pesticide law that has been on the books ...
... FRANKLIN LAKES, N.J., March 7 BD (Becton,Dickinson and Company) ... that it would present at the following investor healthcare,conferences:, ... 13, 2008 8:45 a.m. Greenwich Mean Time (4:45 a.m. ... Company 28th Annual Healthcare Conference March 20, 2008 ...
Cached Biology Technology:Ortho Biotech Modifies Prescribing Information for PROCRIT(R) (Epoetin alfa) 2Ortho Biotech Modifies Prescribing Information for PROCRIT(R) (Epoetin alfa) 3Ortho Biotech Modifies Prescribing Information for PROCRIT(R) (Epoetin alfa) 4Ortho Biotech Modifies Prescribing Information for PROCRIT(R) (Epoetin alfa) 5Ortho Biotech Modifies Prescribing Information for PROCRIT(R) (Epoetin alfa) 6Ortho Biotech Modifies Prescribing Information for PROCRIT(R) (Epoetin alfa) 7
...
... An entire pressurized perfusion system ... in physiology, biophysics, electrochemistry, or general ... as little as 100 microliters of ... eight solutions in milliseconds from a ...
...
Request Info...
Biology Products: