Navigation Links
New data from studies bolsters case for using aldosterone antagonists in heart failure
Date:9/19/2011

t will discuss the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) study, a multi-center, international trial of spironolactone that began in 2006 and is still recruiting treatment centers and enrolling participants. Patients in this study have heart failure but have not experienced disturbed function in the heart's ventricles.

Hyperkalemia Remains a Concern

Although there is substantial evidence of the benefits of aldosterone antagonists, hyperkalemia remains a concern. To that end, researchers are currently investigating a compound called RLY5016 that is designed to prevent or treat hyperkalemia by binding to potassium and pulling it out of the blood. However, the compound is only in Phase II clinical trials and will not be ready for review by the Food and Drug Administration for several years.

Dr. Pitt is cautiously hopeful. "Many of the people who are at risk for cardiovascular death, such as those with a history of diabetes or high blood pressure, are not treated with these drugs because of the risk of hyperkalemia," he said. "Ideally this compound would allow us to continue to use aldosterone antagonists in these patient groups, and in people with compromised renal and uretal function, who are at increased risk of hyperkalemia. But it is very early in the investigation and not proven by any means."


'/>"/>

Contact: Donna Krupa
dkrupa@the-aps.org
301-634-7209
American Physiological Society
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New studies find global warming will have significant economic impacts on Florida coasts
2. NIHs Genes, Environment and Health Initiative adds 6 studies
3. 6 environmental research studies reveal critical health risks from plastic
4. NIAID funds studies of how SARS and bird flu evade antiviral responses
5. Drug-embedded microparticles bolster heart function in animal studies
6. ASU researchers receive NIH awards for studies of malaria and emergent disease
7. Studies of small water fleas help ecologists understand population dynamics
8. MSU researcher studies ties between cholesterol drugs, muscle problems
9. UI researchers help to improve carbon measurements in global climate studies
10. Studies on imaging and tracking transplanted cells
11. To improve forecasting earthquakes, NJIT mathematician studies grains
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/14/2014)... protein, discovered in 2005, controls T-cell activation and ... In doing so, it helps to guarantee immunological ... own structures that can lead to autoimmune disease. ... affect between five and ten per cent of ... of complex environmental influences when a genetic predisposition ...
(Date:7/14/2014)... 140 years ago, Charles Darwin noticed something peculiar about ... are more tame, and they also tend to display ... patches of white fur, and more juvenile faces with ... pattern has proved elusive, but now, in a Perspectives ... new hypothesis has been proposed that could explain why ...
(Date:7/13/2014)... women suggests that experiencing one or more stressful events ... slow the body,s metabolism, potentially contributing to weight gain. ... stressors before giving them a meal consisting of 930 ... measured their metabolic rate how long it took ... took measures of blood sugar, triglycerides, insulin and the ...
Breaking Biology News(10 mins):Molecular mechanisms underlying the prevention of autoim-munity by Roquin revealed 2Domestication syndrome: White patches, baby faces and tameness 2Weighty issue: Stress and high-fat meals combine to slow metabolism in women 2Weighty issue: Stress and high-fat meals combine to slow metabolism in women 3Weighty issue: Stress and high-fat meals combine to slow metabolism in women 4
... Florida State University marine biologist David L. Kimbro will ... in a massive effort to study the health and ... estuaries spanning 1,000 miles of Atlantic and Gulf of ... June 1, has become even more vital now following ...
... fluent in English whose first language is Chinese retrieve their ... in the June 2 issue of The Journal of ... second language in adolescence or later recall the sounds of ... study, Yan Jing Wu, PhD, and Guillaume Thierry, PhD, of ...
... release is available in <A HREF=",http://chinese.eurekalert.org/zh/pub_releases/2010-06/sfeb-tio060110.php,">Chinese . ... of Medicine, in New Orleans, LA, have demonstrated ... seed oil ( Nigella sativa ) can suppress ... cell lines, in vitro. Although previous studies ...
Cached Biology News:Oil spill reshapes sweeping new study of oyster reefs -- Virginia to Florida 2Oil spill reshapes sweeping new study of oyster reefs -- Virginia to Florida 3Oil spill reshapes sweeping new study of oyster reefs -- Virginia to Florida 4Second language learners recall native language when reading 2Thymoquinone induced oxidative stress targets highly aggressive prostate cancers 2
(Date:7/11/2014)... , July 11, 2014 Research and ... Transfection Technology Market - Global Industry Analysis, Size, Share, ... their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... nucleic acids (either DNA or RNA) into cells. This ... of cancer cells and protein metabolism by affecting the ...
(Date:7/11/2014)... 2014 /CNW/ - Sunovion Pharmaceuticals Canada Inc. (Sunovion) today ... acetate) for use as a once-daily adjunctive therapy for ... who are not satisfactorily controlled with conventional therapy.  APTIOM ... under 18 years of age. Epilepsy ... according to Epilepsy Canada, it affects 0.6% of the ...
(Date:7/10/2014)... Ouagadougou, Burkina Faso (PRWEB) July 10, 2014 ... Burkina Faso, today have access to an additional ... to increase access to contraception at all levels ... combining a lower-dose formulation of a widely used ... injection system. , Burkina Faso is the first ...
(Date:7/10/2014)... 10, 2014 Understanding the need for ... lines, and the gap that currently exists in this ... its industry-leading portfolio of validated ion channel and GPCR ... cell lines, as ion channels control many critical physiological ... activity creates the potential to treat a variety of ...
Breaking Biology Technology:International Transfection Technology Market - Industry Analysis, Size, Share, Growth, Trends and Forecast to 2019 2Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 2Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 3Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 4Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 2Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 3Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 4Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 5Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 6Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 2Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 3
... Role of Chairman of the Board - , , ... INSM ), a biopharmaceutical company, today announced that Geoffrey Allan, ... Chairman of the Board of Directors, effective immediately, due to ... President, Chief Executive Officer and Chairman of the Board since ...
... , , , PHILADELPHIA, June 15 ERT ... and eClinical technology, ePRO, and other services to the biopharmaceutical, medical ... its portfolio of products and services at Booth #507 at the ... , , ERT will be showcasing, for the first ...
... returns to Paris for 2010 when, with ICSE, PMEC and BioPh, the ... on Tuesday 5 - Thursday 7 October. This is a week earlier ... to the dates of the last staging in Paris ... the quartet of co-located events to rival the 25,000+ attendees expected this ...
Cached Biology Technology:Insmed CEO Resigns Due to Health Concerns 2Insmed CEO Resigns Due to Health Concerns 3ERT to Showcase Its Clinical Trials Portfolio at DIA's 45th Annual Meeting at Booth #507 2ERT to Showcase Its Clinical Trials Portfolio at DIA's 45th Annual Meeting at Booth #507 3Paris Dates for CPhI Worldwide 2010 2