Navigation Links
New cutting-edge cell research will lead to safer medical experiments on humans
Date:4/10/2013

e dispersed into less crowded conditions. Trypsinisation will thus 'keep the laboratory cells alive' - but it kills their ability to communicate.

"Cells grown in normal laboratory conditions do not react like natural cells in the human body, and therefore they all-too-often give erroneous messages about how a drug works in the human organism. When you are testing the toxicity of a substance - which you always do because of the possible dangers - there is a risk that the trypsin-treated cells report back that they can tolerate the substance, but when one tests the substance on a real person, the effect can actually be fatal, "explains Stephen Fey.

In extreme cases, studies show that both laboratory grown cells and animals tolerate a drug, but human test subjects don't as seen in as in the U.S. fialuridin-tragedy (and several other studies since).

"With our 3D culture method, cells mimic cells in the human body better and thus we get more appropriate results," says Stephen Fey.

"By avoiding trypsinizing cells, they keep their ability to communicate. To avoid using trypsin, cells are grown in small round 3D structures, called spheroids, in a solution, which is constantly being turned. This tricks them into thinking that they are in a tissue surrounded by blood in a natural human body, "explains Stephen Fey.

He refers to cells grown in this way as 3D cell cultures because they live in a three dimensional space as opposed to the traditional methods (which use trypsin) and grow cells on a two-dimensional surface, the bottom of a container.

The researchers from SDU have managed to grow human liver cells, which have a lot more similarities with liver cells in the human body and thus are a lot more valuable than the trypsinized cells, normally used by the pharmaceutical industry.

"Our research shows that we can now predict the dose at which a substance becomes toxic for humans more accurately than before and thu
'/>"/>

Contact: Birgitte Svennevig
birs@sdu.dk
University of Southern Denmark
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Research reveals first evidence of hunting by prehistoric Ohioans
3. Diabetes Research Institute develops oxygen-generating biomaterial
4. APS issues new policy requiring identification of sex or gender in reporting scientific research
5. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
6. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
7. U of Alberta researcher steps closer to understand autoimmune diseases
8. Research on flavanols and procyanidins provides new insights into how these phytonutrients may positively impact human health
9. A project to research biological and chemical aspects of microalgae to fuel approach
10. Scripps Research discoveries lead to newly approved drug for infant respiratory distress syndrome
11. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... , Dec. 22, 2014  NXT-ID, Inc. (NASDAQ: NXTD ... company focused on the growing mobile commerce market, announces it ... Robbins for the 2015 International CES debut of the ... will be at the NXT-ID booth January 6th and ...
(Date:12/19/2014)... Research and Markets ( http://www.researchandmarkets.com/research/8kmfcn/iphone_5s ) has ... Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report" ... http://photos.prnewswire.com/prnh/20130307/600769 Following the acquisition of ... feature with the iPhone 5S. It is currently the ...
(Date:12/19/2014)... Dec. 18, 2014   LaunchKey , the first decentralized ... and Internet of Things era, today announced the close ... round was led by Metamorphic Ventures with participation from ... VegasTechFund, and others.  LaunchKey has raised $4 million to ...
Breaking Biology News(10 mins):NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3
... diseases such as schizophrenia, major depression and cancer ... of dysfunctional genes. A novel computational biology method ... Abdi, PhD, http://www.njit.edu/news/2008/2008-367.php , associate professor in ... found a way to uncover the critical genes ...
... day Americans elect a new president, one of the nation,s ... Houston and outline the daunting global warming challenges awaiting the ... analysis at the National Center for Atmospheric Research (NCAR) in ... a colloquium Tuesday, Nov. 4. The event is free ...
... granted to the laboratory of William Roush, Ph.D., ... Research Institute. Other participants in the consortium are ... California, San Francisco (UCSF), and University of Washington. ... Translational Research Institute Medical Chemistry division and professor ...
Cached Biology News:NJIT professor finds engineering technique to identify disease-causing genes 2Climate change expert to discuss grim global warming predictions 2Scripps Florida scientists awarded $1.5M to fight major water and food parasites 2
(Date:1/22/2015)... | RBJ today announces the firm brokered a long-term lease ... leading biopharmaceutical company, at Two Ledgemont Center in ... , president, and Brian Cohen , senior vice president, ... at 95 Hayden Ave. Photo - http://photos.prnewswire.com/prnh/20150122/170765 ...
(Date:1/22/2015)... BOSTON , Jan. 22, 2015  Transwestern | RBJ today ... feet of office space for Shire a leading biopharmaceutical company, ... . Transwestern | RBJ,s Robert Richards , president, and ... the lease for the entire five-floor building at 95 Hayden ...
(Date:1/22/2015)... 2015 The laboratory information management systems ... a number of technological advancements due to factors such ... need to integrate healthcare systems, and increasing government support ... system integration. Key players in the market focus on ...
(Date:1/22/2015)... Rootstown, OH (PRWEB) January 22, 2015 Crystal ... announced today that it has received AOAC-PTM Certifications for the ... O111, O121, and O145; collectively referred to as STEC or ... at 1 colony forming unit (cfu) per 325 g of ...
Breaking Biology Technology:Transwestern | RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Transwestern?RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 2Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 3Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 4Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2
... Cord Blood America, Inc . ( www.cordblood-america.com ) ... blood stem cell preservation company focused on bringing ... and internationally, today announced that revenues for 2011 increased 37 ... The Company announced a gross profit increase in 2011 of ...
... 2012   HemoShear, LLC , a biotechnology research company ... systems for discovery and assessment of new drug compounds, ... Heart Association,s Arteriosclerosis, Thrombosis and Vascular Biology (ATVB) conference ... at the Hilton Chicago, 720 South Michigan Avenue in ...
... A recent solicitation by the Defense Logistics Agency ... a deluge of orders for emergency radiation products supplier ... tablets provide protection against radioactive iodine in the event ... of nuclear weaponry in Asia and the Middle East ...
Cached Biology Technology:Cord Blood America Revenues Up 37 Percent to $5.67 Million in 2011 2HemoShear to Present at Arteriosclerosis, Thrombosis and Vascular Biology (ATVB) Conference 2Potassium Iodide Sales Surge on Heels of Large Government Order 2
... can provide custom microplate coating using advanced automated high throughput ... plate formats. We can also accommodate virtually any lot size ... L):, , 8 and ... microplate, 384 well microplate, ...
...
A flexible 24-48 hour DNA sequencing service. Samples may be shipped in standard 1.5mL tubes. Oligo synthesis and DNA preparation available. Read lengths up to 850 Phred 20 bases. Universal primers p...
... automated, GLP-compliant Facility , Galaxy LIMS, Sophisticated ... Highly experienced scientists ,We offer individual sample ... full plasmids for single or double strand ... when the DNA of interest is 1.3 ...
Biology Products: