Navigation Links
New cutting-edge cell research will lead to safer medical experiments on humans
Date:4/10/2013

In almost 90 per cent of cases, novel drugs tested on humans by pharmaceutical companies do not work as intended and must be scrapped. Often the drugs do not work, while at worst, test subjects die. New research from the University of Southern Denmark now shows that this number can be reduced. The secret is to test the drug on cells grown as 3D structures.

In 1993, five out of 15 liver patients who participated in a medical trial following the American Federal Drug Administration's (FDA's) instructions died. The patients had been treated with the substance fialuridin that should treat them for the disease hepatitis B. The substance was tested in the laboratory and on animals and had been evaluated as safe for human testing.

Surprisingly it turned out that the substance was acutely lethal to humans and led to extensive liver failure. Five patients died and two others only survived because they received a liver transplant.

When researchers develop new medicines, there are not just billions of dollars and years of research on the line. Patient safety is also at stake.

Now, new research from the University of Southern Denmark shows that the safety for people participating in medical experiments can be improved.

"With our new technique the pharmaceutical industry can better avoid harmful or even fatal effects on medical test subjects," says cell researcher Stephen Fey from the University of Southern Denmark.

When a new drug is developed, its individual active substances are first tested for adverse effects. All substances in the world are potentially deadly if the dose is high enough this was first stated by the German-Swiss scientist Paracelsus (1493 - 1541) in the Renaissance. The challenge is to find substances that have a positive, healing effect and not a toxic or deadly one.

The substances are often tested on human liver cells in the laboratory. If liver cells do not respond negatively to the
'/>"/>

Contact: Birgitte Svennevig
birs@sdu.dk
University of Southern Denmark
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Research reveals first evidence of hunting by prehistoric Ohioans
3. Diabetes Research Institute develops oxygen-generating biomaterial
4. APS issues new policy requiring identification of sex or gender in reporting scientific research
5. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
6. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
7. U of Alberta researcher steps closer to understand autoimmune diseases
8. Research on flavanols and procyanidins provides new insights into how these phytonutrients may positively impact human health
9. A project to research biological and chemical aspects of microalgae to fuel approach
10. Scripps Research discoveries lead to newly approved drug for infant respiratory distress syndrome
11. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... SAN DIEGO, Calif. (Sept. 17, 2014) A rare genetic ... autism, according to a recent joint investigation by researchers ... California, San Diego. In addition to suggesting better treatment ... offers more clues into the genetic underpinnings of autism., ... to the National Institutes of Health. It occurs in ...
(Date:9/17/2014)... at IMIM (Hospital del Mar Medical Research Institute) and ... published a study in eLife showing that ... the evolution of new proteins, some of which could ... produce proteins from the instructions found in an RNA ... RNA containing information for the synthesis of proteins, meaning ...
(Date:9/17/2014)... DALLAS September 17, 2014 Researchers at UTSouthwestern ... of the circulating protein apolipoprotein E, called apoE3, helps ... variant, called apoE4, do not get the benefit of ... disease. , "We believe that we have identified one ... and why a genetic variant, apoE4, is detrimental," said ...
Breaking Biology News(10 mins):A link between Jacobsen syndrome and autism 2Parts of genome without a known function may play a key role in the birth of new proteins 2Protein variant may boost cardiovascular risk by hindering blood vessel repair 2
... India using their current arsenals could create a near-global ... havoc for at least a decade, according to a ... The computer-modeling study showed a nuclear war ... on each side would cause massive urban fires and ...
... at NJIT for early diagnosis of Alzheimers, Parkinsons and ... a recent New Jersey Technology Council competition. Based ... NeuroTrax www.neurotrax.com , a start-up company, was named ... companies and 500 entrepreneurs and investors. ...
... may begin in the womb, researchers from Tel Aviv University ... twin can compromise the health of his twin sister before ... published in the journal Pediatrics, the researchers analyzed the incidence ... twins. When born premature, girls who share the womb with ...
Cached Biology News:Regional nuclear conflict would create near-global ozone hole, says CU-Boulder study 2Regional nuclear conflict would create near-global ozone hole, says CU-Boulder study 3NJIT start-up company NeuroTrax named best in show 2War between the sexes begins before twins' birth, TAU researchers say 2
(Date:9/18/2014)... at USC have developed a new microscopy technology ... living animals at higher-than-ever resolution. , Dubbed "Complementation ... imaging resolutions that are an order of magnitude ... into the behavior of biomolecules at the nanometer ... 18 by Nature Communications , the researchers ...
(Date:9/18/2014)... MX (PRWEB) September 18, 2014 September ... Mexico City, MX. ASEA is the manufacturer of the ... the skin care product, RENU28. , The Mexico ... Vice President Duvan Botero, and ASEA Field Leader Shawn ... holds a PhD in Atomic/Medical Physics from the University ...
(Date:9/17/2014)... - Oncothyreon Inc. (NASDAQ: ONTY ) today ... of its Common Stock and Series A Convertible Preferred ... Series A Convertible Preferred Stock is non-voting and convertible ... will be prohibited if, as a result, the holder ... of the Common Stock then outstanding. As part of ...
(Date:9/17/2014)... 17, 2014 A biodegradable polymer ... such as bacteria, fungi, and algae into smaller ... biomass, inorganic compounds, carbon dioxide, and humus in ... base and improved costs, biodegradable polymers are proving ... alternative to conventional polymers. Primary factors that are ...
Breaking Biology Technology:Scientists pioneer microscopy technique that yields fresh data on muscular dystrophy 2Announcing the ASEA Mexico Grand Opening Tour Beginning September 18th 2Oncothyreon Announces Proposed Public Offerings 2Growing Demand for Eco-Friendly Products Drives the Global Biodegradable Polymers Market, According to New Report by Global Industry Analysts, Inc. 2Growing Demand for Eco-Friendly Products Drives the Global Biodegradable Polymers Market, According to New Report by Global Industry Analysts, Inc. 3
... Sodium gets a bad rap for contributing to hypertension and ... Arts and Sciences have discovered that sodium also plays a ... The Tufts scientists have found a way to regenerate ... to trigger an influx of sodium ions into injured cells. ...
... clean-room world of silicon wafers and solar cells, it turns ... perhaps all the way to making solar power an affordable ... light ricocheting around inside the polymer film of a solar ... film that,s nanoscale-thin and has been roughed up a bit ...
... Decision Resources, one of the world,s leading research ... that, owing to increasing generic availability of antihypertensive agents, ... in 2009 to $23 billion in 2019 in the ... Japan. The Pharmacor 2010 findings from the ...
Cached Biology Technology:Sodium plays key role in tissue regeneration 2Sodium plays key role in tissue regeneration 3Solar cells thinner than wavelengths of light hold huge power potential 2Solar cells thinner than wavelengths of light hold huge power potential 3Due to Generic Erosion, the Hypertension Drug Market Will Decline by $3 Billion from 2009 to 2019 2
Lyophilized solid. Suitable for evaluating functional activity of human complement components and for other research requiring a high level of hemolytic activity. ...
... systems are high-precision microarrayers capable of ... samples. VersArray ChipWriter Pro systems set ... and reproducibility to deliver unparalleled quality ... Their modular component design and flexible ...
Thermal printer paper is used with the thermal printer for the VersaFluor fluorometry systems. Supplied as 10 rolls....
... Gel extraction kit, 100 preps Storage: The kit ... For longer storage, keep all contents of the ... column purification kit utilizes a silica-gel based membrane ... fragments in the presence of specialized binding buffers. ...
Biology Products: