Navigation Links
New culture dish could advance human embryonic stem cell research
Date:6/2/2010

ANN ARBOR, Mich.---A new synthetic Petri dish coating could overcome a major challenge to the advancement of human embryonic stem cell research, say University of Michigan researchers.

Under today's regulations, current stem cell lines have limitations in yielding human therapies because the cells have been grown on animal-based substances that don't behave in predictable ways.

"These nondefined, animal-based components create issues with the FDA (the U.S. Food and Drug Administration) and hinder clinical applications," said Joerg Lahann, associate professor of chemical engineering.

Lahann and Gary Smith, an associate professor in obstetrics and gynecology in the U-M Health System, and their co-workers built a new stem cell growth matrix that is completely synthetic and doesn't contaminate the stem cells with foreign substances that could interfere with their normal function.

A paper on the research was published online this week in Nature Biotechnology.

Today's most commonly used matrices are mouse embryonic fibroblast cells and Matrigel, which is made from mouse tumors.

"The problem is that the mouse-derived cells have batch-to-batch variability, and they secrete factors that nobody really understands. Stem cells are very sensitive to their environment," Lahann said.

The unknown factors hamper researchers' attempts to pinpoint how and under what conditions stem cells differentiate---questions paramount to the development of future stem cell therapies.

The team tested six different polymer coatings and found that a water-soluble gel with the acronym PMEDSAH performed well when attached to the Petri dish even after 25 rounds of harvesting stem cells to grow new colonies.

"We have designed a fully synthetic, fully chemically defined hydrogel that has long-term stability and no batch-to-batch variability," Smith said. "Moreover, we have established that it can be used for
'/>"/>

Contact: Nicole Casal Moore
ncmoore@umich.edu
734-647-7087
University of Michigan
Source:Eurekalert

Page: 1 2

Related biology news :

1. Novel 3-D cell culture model shows selective tumor uptake of nanoparticles
2. Emphasizing the precision in precision agriculture
3. Thumb-size microsystem enables cell culture and incubation
4. Agriculture experts meet in Beijing to examine impacts of food prices and climate change on farmers
5. MIT: Culture influences brain function
6. Agriculture is changing the chemistry of the Mississippi River
7. Stevens researchers provide oversight for three-year mariculture program in Egypt and Israel
8. Tomato pathogen genome may offer clues about bacterial evolution at dawn of agriculture
9. Aquaculture concept leaves judges goggle eyed
10. Ancient sunflower fuels debate about agriculture in the Americas
11. New study points to agriculture in frog sexual abnormalities
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/16/2014)... researchers have challenged conventional thinking on how the bowel ... mechanism for how bowel cancer starts. , The researchers ... and regenerating the ,crypts, that are a feature of ... involved in bowel cancer development, a controversial finding as ... , Using 3D imaging technologies, Dr Chin Wee Tan ...
(Date:10/16/2014)... Conn. , October 16, 2014 NXT-ID, ... or the "Company"), a biometric authentication company focused on ... its leading edge technologies including Wocket™, the Smart Wallet, ... (FiRe) Conferenece. FiRe is a leading global conference on ... Hosted by Mark Anderson , founder and ...
(Date:10/15/2014)... Johannes Gutenberg University Mainz (JGU) as a full ... to maintain a significant nationwide standing in the ... of Johannes Gutenberg University Mainz as a full ... the national and international competition for the best ... can be proud that Mainz University has been ...
Breaking Biology News(10 mins):Cryptic clues drive new theory of bowel cancer development 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 3Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 3
... pollutants into our waters and atmosphere could soon be ... Presenting their research today, 26 June, in IOP ... Universit de Technologie de Compigne, believe their work ... the exact location where pollutants have been leaked as ...
... Imaging is the first handbook of its ... visualization of microcirculation. Clearly structured throughout, this ... researcher relying on microcirculation imaging. , Author Professor ... Ireland, Galway, explores everything from basic research to ...
... , GAINESVILLE, Fla. --- The BP Deepwater Horizon oil spill ... as erosion, but there may be cause for optimism, according ... in the Proceedings of the National Academy of Sciences ... 15 to 30 feet from the shoreline and this plant ...
Cached Biology News:Maths formula leads researchers to source of pollution 2BP Deepwater Horizon oil spill exacerbated existing environmental problems in Louisiana marshes 2BP Deepwater Horizon oil spill exacerbated existing environmental problems in Louisiana marshes 3
(Date:10/22/2014)... October 21, 2014 The North American ... market North America with analysis and forecast of revenue. ... and is expected to reach $623.6 million by 2018, ... , Browse through the TOC of the North American ... the in-depth analysis provided. This also provides a glimpse ...
(Date:10/22/2014)... 2014 Currently offering a comprehensive ... D Weighing, Rice Lake, and Ohaus, Pipette.com has ... The Sartorius CPA Semi-Micro Balance is ideal for ... and user-friendly laboratory balance. , Sartorius is a ... laboratory balances are well known for their high ...
(Date:10/22/2014)... 22, 2014   Synthetic Biologics, Inc. (NYSE ... for serious infections and diseases, announced today that the ... of Allowance for a composition of matter patent application ... program, SYN-004. This is Synthetic Biologics, first allowed ... and adds to the Company,s extensive C. difficile ...
(Date:10/22/2014)... and HONG KONG , ... rare disease therapeutics enterprise, announced today that rare disease ... company as vice president, research. Dr. McKew brings more ... key leadership positions at the National Institutes of Health, ... acquisition by Wyeth). Dr. McKew will lead aTyr,s efforts to ...
Breaking Biology Technology:The North American crystal oscillator market is expected to reach $623.6 million by 2018 - New Report by MicroMarket Monitor 2The North American crystal oscillator market is expected to reach $623.6 million by 2018 - New Report by MicroMarket Monitor 3The North American crystal oscillator market is expected to reach $623.6 million by 2018 - New Report by MicroMarket Monitor 4Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 2Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 3Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 2Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 3Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 4aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 2aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 3
... Inc.,(Nasdaq: ITMN ) today announced that Daniel G. ... at the Thomas Weisel,Healthcare Conference in Boston on September ... present at the Bear Stearns 20th Annual Healthcare,Conference in ... p.m. EDT. To access a live audio webcast ...
... FRANCISCO, Calif., Aug. 30 VaxGen,Inc. (Pink Sheets: ... the,Securities and Exchange Commission (SEC) its Annual Report ... 2006 and Quarterly Reports on Form 10-Q for ... be found at the link titled,"SEC Filings" in ...
... Limited (ASX: PGL; Nasdaq: PGLA) today announced that,Justus Homburg, ... Healthcare Conference at The Four Seasons Hotel in Boston, ... The audio presentation will be webcast live, and ... . A replay of the webcast will be,available for ...
Cached Biology Technology:InterMune to Present at Thomas Weisel and Bear Stearns Healthcare Conferences 2VaxGen Files 2006 Financial Statements and Provides Cash Update 2
PlusOne Acrylamide PAGE, 1 kg. Category: Electrophoresis Systems & Standards & Reagents, Electrophoresis Standards and Reagents, Gel Casting Chemicals....
Donor Horse Serum US Origin...
jub, ajuba homolog (Xenopus laevis)...
Size & Applications: 100 ul (2 mM). Recommend to use at 1000X dilutions for cell culture (e.g. Add 1 ul to 1 ml of culture medium.) Storage Temp.: -20C Shelf Life: 6-12 month...
Biology Products: