Navigation Links
New 'control knobs' for stem cells identified
Date:12/3/2008

MEDFORD/SOMERVILLE, Mass. Natural changes in voltage that occur across the membrane of adult human stem cells are a powerful controlling factor in the process by which these stem cells differentiate, according to research published by Tufts University scientists.

Tufts doctoral student Sarah Sundelacruz, Professor of Biology Michael Levin, and Chair of Biomedical Engineering David L. Kaplan (corresponding author) published their paper "Membrane Potential Controls Adipogenic and Osteogenic Differentiation of Mesenchymal Stem Cells" in the November 17, 2008, issue of PLoS ONE (http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0003737).

"We have found that voltage changes act as a signal to delay or accelerate the decision of a stem cell to drop out of a stem state and differentiate into a specific cell type. This discovery gives scientists in regenerative medicine a new set of control knobs to use in ongoing efforts to shape the behavior of adult stem cells," said Levin. "In addition, by uncovering a new mechanism by which these cells are controlled in the human body, this research suggests potential future diagnostic applications."

Harnessing the potential of stem cells for applications such as wound healing and tissue regeneration is a tantalizing yet daunting task. Although many studies indicate that electrophysiology plays a crucial role in cell proliferation and differentiation, its functional role in stem cell biology is poorly understood.

The Tufts researchers studied the changes in membrane potential (voltage across the membrane) shown by human mesenchymal stem cells (hMSCs) obtained from donor bone marrow as the hMSCs were differentiating into fat and bone cells. They found that hyperpolarization (increased difference between the voltage in the interior and exterior of a cell) was characteristic of
'/>"/>

Contact: Kim Thurler
kim.thurler@tufts.edu
617-627-3175
Tufts University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Cool idea for efficient climate control wins recognition
2. A scientific breakthrough on the control of the bad cholesterol
3. Futronic Launches FS22 Fingerprint Access Control Device
4. New insight into the controls on a go-to enzyme
5. Ultrasound shown to exert remote control of brain circuits
6. Boost from McGill, Gates Foundation helps Africans control pharma research
7. Birth control has long-term effect on hormone exposure
8. Waste from gut bacteria helps host control weight, UT Southwestern researchers report
9. Genes that control cell death fingered in age-related hearing loss
10. Can genetic information be controlled by light?
11. bioMETRX, Inc. Signs Deal To Acquire Controlling Interest in Biometric Solutions, LLC
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... University, Sweden, have explored two different ways that ... leading to the formation of oxygen molecules in ... the scientific journal Nature Communications . , ... synthetic catalysts for water oxidation, which are key ... direct storage of solar energy in fuels like ...
(Date:7/11/2014)... under the normal circumstances, astrocytes participate in ... environment, and exhibit therapeutic and repairing effects ... studies have found that nerve cells differentiated ... have reduced viability, which produces influences on ... Kailuan General Hospital, Hebei United University, China ...
(Date:7/10/2014)... and other major cities in New Mexico, nearly every ... wastewater rather than precious potable water supplies. Across the ... all golf courses receive treated effluent. Reusing the effluent ... golf courses and homeowners alike fertilize their lawns during ... nitrate. A New Mexico State University turfgrass expert has ...
Breaking Biology News(10 mins):Molecular snapshots of oxygen formation in photosynthesis 2'Tailored' water -- the latest in lawn care 2
... explain the response of patients with chronic obstructive pulmonary ... reported today (Oct. 25) at the American Society of ... used statistical methods to combine results from four individual ... moderate to severe COPD. Over 6.3 million unique ...
... cells. They,re equally indispensible in both cases. Without our bony ... cytoskeletons, our cells, which come in roughly 200 different shapes ... Using cells from the stem of a seedling as ... St. Louis seeks to understand the molecular mechanisms that organize ...
... is hosting the region,s leading scientists for discussions ... most devastating and intractable diseases of humans, including ... fungal meningitis. The Cell Biology of Eukaryotic ... campus and provides an environment for scientific discussions ...
Cached Biology News:DNA variants may influence COPD patients' response to inhaled bronchodilators 2Samurai sword protein makes strategic cuts in cell skeletons 2Samurai sword protein makes strategic cuts in cell skeletons 3Samurai sword protein makes strategic cuts in cell skeletons 4Samurai sword protein makes strategic cuts in cell skeletons 5
(Date:7/11/2014)... AZ (PRWEB) July 11, 2014 ... device company specializing in the soft tissue reconstruction ... All-Suture Anchor System for surgeries involving the shoulder ... fixation through a novel, inserter-controlled deployment method. The ... to partial deployment, anchor pull-out, or anchor displacement ...
(Date:7/10/2014)... (PRWEB) July 10, 2014 Understanding the ... channel-expressing cell lines, and the gap that currently exists ... that expand its industry-leading portfolio of validated ion channel ... ion channel-expressing cell lines, as ion channels control many ... control this activity creates the potential to treat a ...
(Date:7/10/2014)... CA (PRWEB) July 10, 2014 OMICS ... Bioanalytical techniques during 18-20 August, 2014 at Double Tree ... review the recent developments in Analytical & Bioanalytical research ... globe. , Speaking on this occasion, Dr. Srinubabu Gedela, ... Analytica Acta conference is a remarkable one in bringing ...
(Date:7/10/2014)... 2014 On July 9 Prime ... presented Russia,s first national "Industry" ... Company is developing a unique project called MabNext ... a number of innovative drugs based on monoclonal antibodies ... took place at the International Exhibition "Innoprom 2014" in ...
Breaking Biology Technology:Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 2Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 3Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 2Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 3A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2
... YORK, Sept. 24 Stephen Simes, chief executive,officer ... (http://www.biosantepharma.com ) will be featured in an exclusive ... at 10:30 a.m. EDT. The interview,will be posted ... on September 26. The interview will cover ...
... Kendle (Nasdaq: KNDL ), a,leading, global ... President and Chief Financial Officer Karl,"Buzz" Brenkert, III ... at the Grand Hyatt New York, Park Avenue ... Kendle,s presentation is scheduled for,Wednesday, Sept. 26 at ...
... WILMINGTON, Mass., Sept. 24 OmniSonics Medical,Technologies, Inc., ... vascular disease, today announced the appointment of J. ... Board. Mr. Cole is a founding partner ... focuses exclusively on emerging healthcare technology,companies. He brings ...
Cached Biology Technology:WallSt.net Announces Upcoming Interview with CEO of BioSante Pharmaceuticals 2Kendle to Present at the UBS Global Life Sciences Conference 2OmniSonics Appoints J. Daniel Cole Chairman of the Board 2
...
... Modification Services ,,GenScript offers many ... and antibody fragmentation. Labeling antibodies with ... visualization and quantitation of the target ... preferable to use only the antigen-binding ...
... are designed for ultra-sensitive detection of ... PVDF membranes. Since all necessary reagents ... antibodies), the WesternBreeze Kits save you ... and getting your final results. Solutions ...
Request Info...
Biology Products: