Navigation Links
New computational technique allows comparison of whole genomes as easily as whole books
Date:1/28/2009

Berkeley -- Taking a hint from the text comparison methods used to detect plagiarism in books, college papers and computer programs, University of California, Berkeley, researchers have developed an improved method for comparing whole genome sequences.

With nearly a thousand genomes partly or fully sequenced, scientists are jumping on comparative genomics as a way to construct evolutionary trees, trace disease susceptibility in populations, and even track down people's ancestry.

To date, the most common techniques have relied on comparing a limited number of highly conserved genes - no more than a couple dozen - in organisms that have all these genes in common.

The new method can be used to compare even distantly related organisms or organisms with genomes of vastly different sizes and diversity, and can compare the entire genome, not just a selected small fraction of the gene-containing portion known to code for proteins, which in the human genome is only 1 percent of the DNA.

The technique produces groupings of organisms largely consistent with current groupings, but with some interesting discrepancies, according to Sung-Hou Kim, professor of chemistry at UC Berkeley and faculty researcher at Lawrence Berkeley National Laboratory. However, the relative positions of the groups in the family tree - that is, how recently these groups evolved - are quite different from those based on conventional gene alignment methods.

The computational results have surprised scientists in being able to classify some bacteria and viruses that until now were enigmatic.

The technique, which employs feature frequency profiles (FFP), is described in a paper to appear this week in the early online edition of the journal Proceedings of the National Academy of Sciences.

Current methods for comparing the genomes of different organisms focus on a small set of genes that the organisms being compared have in common. The
'/>"/>

Contact: Robert Sanders
rsanders@berkeley.edu
510-643-6998
University of California - Berkeley
Source:Eurekalert  

Page: 1 2 3 4 5 6

Related biology news :

1. Supercomputer provides massive computational boost to biomedical research at TGen
2. Penn presents inaugural symposium on applied mathematics and computational science
3. Computational biochemist uncovers a molecular clue to evolution
4. Computational mathematical sciences receives NSF grant for undergraduate research
5. Computational actinide chemistry: Are we there yet?
6. Novel technique changes lymph node biopsy, reduces radiation exposure
7. Novel technique changes lymph node biopsy, reduces radiaiton exposure
8. New technique is quantum leap forward in understanding proteins
9. New edition of laboratory manual includes cutting-edge techniques to study gene regulation
10. Novel technique for fluorescence tomography of tumors in living animals
11. These shells dont clam up: Innovative technique to record human impact on coastal waters
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New computational technique allows comparison of whole genomes as easily as whole books
(Date:9/30/2014)... scientists and engineers, led by Clemson University associate ... million grant from the U.S. Department of Energy,s ... a direct positive impact on South Carolina in ... radioactive contaminants. , "Understanding the scientific and engineering ... aspects of nuclear technologies is imperative if South ...
(Date:9/30/2014)... runoff in Hawaii is causing tumors in endangered sea ... published Tuesday in the peer-reviewed open-access journal PeerJ ... in algae that the turtles eat, promoting the formation ... organs. , Scientists at Duke University, the University of ... conducted the study to better understand the causes ...
(Date:9/30/2014)... German . ... risky situations such as exposure to predators. Researchers from ... a long-term study on different populations of great tits ... ambient temperature. High metabolic rates and low temperatures were ... birds were more likely to approach potential predators. , ...
Breaking Biology News(10 mins):Researchers get $5.25 million to advance nuclear technologies in South Carolina 2Pollution linked to lethal sea turtle tumors 2Pollution linked to lethal sea turtle tumors 3Risky metabolism 2
... BLOOMINGTON, Ind. -- Two recently diverged populations of a ... contribute to the reproductive isolation that accompanies the origin ... of organic compounds present in the preen oils of ... Ecology . "There,s so much we don,t know ...
... Age and gender play a major role in how ... 20-to-64-year-olds. Published in the journal Psychophysiology , the investigation ... the Montreal Heart Institute in collaboration with colleagues from the ... findings suggest that women who are more defensive are at ...
... University of Western Ontario finds the sauces you use when ... benefits. The research, led by Western biology and psychology ... than just tasty sauces they can also provide a ... Mark Bernards and Christopher Guglielmo in Western,s department of biology. ...
Cached Biology News:Could smell play a role in the origin of new bird species? 2Could smell play a role in the origin of new bird species? 3Men and women respond differently to stress 2Spice up your health this barbecue season 2
(Date:10/1/2014)... As the world takes its first steps ... that this century would mark the beginning of a new ... science. The fact that the world is experiencing a rapid ... scientific community. Almost half of these chronic conditions are due ... with medical care and intervention. While the world is experiencing ...
(Date:10/1/2014)... 30, 2014 In response to ... to address sales, training and consumer engagement challenges, ... innovative mobile applications to turn their clients’ visions ... latest customized mobile app creations, are now featured ... In partnership with Toyota, StudioPMG created a robust ...
(Date:10/1/2014)... (PRWEB) October 01, 2014 Slone ... Clinical Therapeutics, Healthcare IT, and Laboratory Testing industries, reported ... positions at the director level and above from July ... to stay on top of rapid breakthroughs in diagnostics, ... many diagnostic companies have been forced to fold, consolidate, ...
(Date:10/1/2014)... 30, 2014 This report analyzes ... US$ Million by the following Product Segments: ... Specific end-use segments also analyzed are Pharmaceuticals ... The report provides separate comprehensive analytics for ... East, and Latin America. Annual estimates and ...
Breaking Biology Technology:Fighting Mortality and Morbidity of Chronic Health Disorders during Open Access Week 2Fighting Mortality and Morbidity of Chronic Health Disorders during Open Access Week 3Digital Agency Studio PMG Launches New Case Studies on Website 2Slone Partners Meets Growing Demand as Industry Focuses on Reimbursement & Regulation 2Global Specialty Enzymes Industry 2Global Specialty Enzymes Industry 3Global Specialty Enzymes Industry 4Global Specialty Enzymes Industry 5Global Specialty Enzymes Industry 6Global Specialty Enzymes Industry 7Global Specialty Enzymes Industry 8Global Specialty Enzymes Industry 9Global Specialty Enzymes Industry 10Global Specialty Enzymes Industry 11Global Specialty Enzymes Industry 12Global Specialty Enzymes Industry 13Global Specialty Enzymes Industry 14Global Specialty Enzymes Industry 15Global Specialty Enzymes Industry 16Global Specialty Enzymes Industry 17Global Specialty Enzymes Industry 18Global Specialty Enzymes Industry 19Global Specialty Enzymes Industry 20Global Specialty Enzymes Industry 21Global Specialty Enzymes Industry 22Global Specialty Enzymes Industry 23Global Specialty Enzymes Industry 24Global Specialty Enzymes Industry 25Global Specialty Enzymes Industry 26
... Feb. 25 VIA Pharmaceuticals, Inc. (Nasdaq: ... of compounds for the treatment of cardiovascular and metabolic ... No. 7,495,024 entitled "Phenylalkyl N-Hydroxyureas for Combating Atherosclerotic Plaque", ... the treatment of atherosclerosis. This patent is also ...
... February 25 BN,ImmunoTherapeutics, Inc. announced today that ... was licensed from the National Institutes of,Health (NIH) ... confirms the,excellent safety and efficacy results previously reported, ... (GU) on February 26-28, 2009 in,Orlando, Florida. , ...
... SHENYANG, China, Feb. 25 /PRNewswire-Asia-FirstCall/ -- 3SBio Inc. ... company focused on researching,developing, manufacturing and marketing biopharmaceutical ... for the fourth quarter and,full year ended December ... Wednesday,March 11, 2009. , ...
Cached Biology Technology:VIA Pharmaceuticals Announces Grant of New Patent on Lead Compound VIA-2291 2VIA Pharmaceuticals Announces Grant of New Patent on Lead Compound VIA-2291 3VIA Pharmaceuticals Announces Grant of New Patent on Lead Compound VIA-2291 4BN ImmunoTherapeutics Reports Further Data on PROSTVAC(TM) 2BN ImmunoTherapeutics Reports Further Data on PROSTVAC(TM) 33SBio Inc. to Report 2008 Fourth Quarter and Full Year Earnings on March 11, 2009 2
Applications: Immunohistochemistry, ISH, FISH, CISH....
Polypropylene test tube racks, used in Thermo Forma's line of Test Tube Rack holders...
...
BD FastImmune EDTA Solution. Applications: Flow Cytometry Storage Temperature: Refrigerate(2 to 8C)...
Biology Products: