Navigation Links
New computational technique allows comparison of whole genomes as easily as whole books
Date:1/28/2009

Berkeley -- Taking a hint from the text comparison methods used to detect plagiarism in books, college papers and computer programs, University of California, Berkeley, researchers have developed an improved method for comparing whole genome sequences.

With nearly a thousand genomes partly or fully sequenced, scientists are jumping on comparative genomics as a way to construct evolutionary trees, trace disease susceptibility in populations, and even track down people's ancestry.

To date, the most common techniques have relied on comparing a limited number of highly conserved genes - no more than a couple dozen - in organisms that have all these genes in common.

The new method can be used to compare even distantly related organisms or organisms with genomes of vastly different sizes and diversity, and can compare the entire genome, not just a selected small fraction of the gene-containing portion known to code for proteins, which in the human genome is only 1 percent of the DNA.

The technique produces groupings of organisms largely consistent with current groupings, but with some interesting discrepancies, according to Sung-Hou Kim, professor of chemistry at UC Berkeley and faculty researcher at Lawrence Berkeley National Laboratory. However, the relative positions of the groups in the family tree - that is, how recently these groups evolved - are quite different from those based on conventional gene alignment methods.

The computational results have surprised scientists in being able to classify some bacteria and viruses that until now were enigmatic.

The technique, which employs feature frequency profiles (FFP), is described in a paper to appear this week in the early online edition of the journal Proceedings of the National Academy of Sciences.

Current methods for comparing the genomes of different organisms focus on a small set of genes that the organisms being compared have in common. The
'/>"/>

Contact: Robert Sanders
rsanders@berkeley.edu
510-643-6998
University of California - Berkeley
Source:Eurekalert  

Page: 1 2 3 4 5 6

Related biology news :

1. Supercomputer provides massive computational boost to biomedical research at TGen
2. Penn presents inaugural symposium on applied mathematics and computational science
3. Computational biochemist uncovers a molecular clue to evolution
4. Computational mathematical sciences receives NSF grant for undergraduate research
5. Computational actinide chemistry: Are we there yet?
6. Novel technique changes lymph node biopsy, reduces radiation exposure
7. Novel technique changes lymph node biopsy, reduces radiaiton exposure
8. New technique is quantum leap forward in understanding proteins
9. New edition of laboratory manual includes cutting-edge techniques to study gene regulation
10. Novel technique for fluorescence tomography of tumors in living animals
11. These shells dont clam up: Innovative technique to record human impact on coastal waters
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New computational technique allows comparison of whole genomes as easily as whole books
(Date:11/5/2014)... Brazil -Individuals show great diversity in their ability to ... females greatly differ in their perceptual evaluation of odors, ... tests. , Sex differences in olfactory detection ... may be connected to one,s perception of smell, which ... women,s olfactory superiority has been suggested to be cognitive ...
(Date:11/4/2014)... only marketing directed at children on the interior ... that the majority of black, middle-income and rural ... , Authored by Arizona State University researcher Punam ... first to examine the use of child-directed marketing ... restaurants and its relationship to demographics. It adds ...
(Date:11/3/2014)... Cancer Center study published in this month,s ... describes the activity of a recently discovered communication molecule ... It has been known to limit inflammation and the ... system: IL-37 inhibits the ability of the immune system ... mechanism that underlies IL-37,s effect on the immune system ...
Breaking Biology News(10 mins):The female nose always knows: Do women have more olfactory neurons? 2Fast food marketing for children disproportionately affects certain communities 2Fast food marketing for children disproportionately affects certain communities 3PNAS: From HIV to cancer, IL-37 regulates immune system 2
... King,s College London will today (Tuesday 6 December) announce ... (UKSCB) their first clinical grade human embryonic stem (hES) ... as ,xeno-free, stem cells. The cells, which have ... developing new stem cell-based therapies, will be the first ...
... Thanks to a new study of the retina, scientists ... how the nervous system becomes wired during early development. ... research at UCSB. The work is described in a recent ... research team examined the connectivity of nerve cells, called neurons, ...
... - Researchers have demonstrated a new imaging tool for ... the bloodstream, which could aid efforts to perfect their ... structures have potential applications in drug delivery to treat ... nanotubes are created in the manufacturing process, metallic and ...
Cached Biology News:Stem cell research in the UK reaches significant milestone 2Stem cell research in the UK reaches significant milestone 3Stem cell research in the UK reaches significant milestone 4UCSB scientists make advances in neuroscience and vision research 2UCSB scientists make advances in neuroscience and vision research 3'Label-free' imaging tool tracks nanotubes in cells, blood for biomedical research 2
(Date:11/27/2014)... November 27, 2014 Calcivis, ... management of tooth decay, today announces that it ... Calcivis® Caries Activity Imaging System. The ... medical device and consumable combination designed to transform ... decay). It involves a unique, proprietary bioluminescence approach ...
(Date:11/26/2014)... 2014 Deep Research Report on ... in-depth research report on the Ammonium Bifluoride market, ... classification, application, and industry chain structure as well ... market analysis, including China’s domestic market as well ... China, Japan etc. regions) industry analysis covering macroeconomic ...
(Date:11/26/2014)... and PHILADELPHIA , Nov. 26, 2014 ... and unforgiving environments. Human exploration of space requires astronauts ... ensure mission safety and success, and prevent potential errors ... mission success, little is known about how cognition is ... are primarily affected. Now, Penn Medicine researchers ...
(Date:11/26/2014)... 26, 2014 PMG Research, Inc. ... Research is a network of sites that provide clinical research ... 2 million patient lives through its partnerships with large physician ... 11 hub site locations in the Southeastern United States and ... of the board will be held by: Dr. ...
Breaking Biology Technology:Calcivis Completes Clinical Study of Novel Caries Activity Imaging System 2Calcivis Completes Clinical Study of Novel Caries Activity Imaging System 3Ammonium Bifluoride Market International Analysis of Manufacturing, Technology & Trends Now at ReportsnReports.com 2Ammonium Bifluoride Market International Analysis of Manufacturing, Technology & Trends Now at ReportsnReports.com 3Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 2Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 3Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 4PMG Research Names Medical Advisory Board 2PMG Research Names Medical Advisory Board 3
... and Yale universities have successfully transplanted most of the "nose" ... fruit flies and are employing these surrogates to combat the ... million people. The research is described in two complimentary ... of the Proceedings of the National Academy of Sciences ...
... ... World Europe conference in Brussels addresses the 4 key pillars of ... of the algae value chain. Panel of industry experts will also ... pharmaceuticals, nutraceuticals, cosmetics, aquaculture feed, bioplastics, coatings, etc. The program includes ...
... Feb. 12 CoAxia™, Inc. of Maple Grove, ... SENTIS randomized, controlled, pivotal trial of NeuroFlo™ Perfusion Augmentation Therapy ... plans to complete data collection and analysis of results in ... the US FDA. , Ischemic stroke is one of the ...
Cached Biology Technology:Scientists transplant nose of mosquito, advance fight against malaria 2Scientists transplant nose of mosquito, advance fight against malaria 32nd Algae World Europe Tracks Algae Commercialization from Algae Production to High-value Products- Nutraceuticals, Aquaculture Feed, Cosmetics, Biofuels and More 22nd Algae World Europe Tracks Algae Commercialization from Algae Production to High-value Products- Nutraceuticals, Aquaculture Feed, Cosmetics, Biofuels and More 3CoAxia Announces Completion of Enrollment in Ischemic Stroke Trial 2CoAxia Announces Completion of Enrollment in Ischemic Stroke Trial 3
... Kit, Protein, 1. Based on the ... the kit gives essentially colorless backgrounds ... Kit, Protein provides convenient, reproducible and ... gels in less than two hours.The ...
All serum is collected from adult animals aged 6 months or older. Certified U.S. orgin. Pricing: $35/unit for 1 - 10 units...
Natural Mouse Laminin is purified from the Engelbreth-Holm-Swarm (EHS) sarcoma and is provided in Tris-buffered saline....
... • Guinea Pig serum is collected from ... N-02: Citrate N-04: Heparin ... Potassium Oxalate N-10: EDTA (Na) ... N-07: CPD N-09: K3EDTA ...
Biology Products: