Navigation Links
New computational technique allows comparison of whole genomes as easily as whole books

Berkeley -- Taking a hint from the text comparison methods used to detect plagiarism in books, college papers and computer programs, University of California, Berkeley, researchers have developed an improved method for comparing whole genome sequences.

With nearly a thousand genomes partly or fully sequenced, scientists are jumping on comparative genomics as a way to construct evolutionary trees, trace disease susceptibility in populations, and even track down people's ancestry.

To date, the most common techniques have relied on comparing a limited number of highly conserved genes - no more than a couple dozen - in organisms that have all these genes in common.

The new method can be used to compare even distantly related organisms or organisms with genomes of vastly different sizes and diversity, and can compare the entire genome, not just a selected small fraction of the gene-containing portion known to code for proteins, which in the human genome is only 1 percent of the DNA.

The technique produces groupings of organisms largely consistent with current groupings, but with some interesting discrepancies, according to Sung-Hou Kim, professor of chemistry at UC Berkeley and faculty researcher at Lawrence Berkeley National Laboratory. However, the relative positions of the groups in the family tree - that is, how recently these groups evolved - are quite different from those based on conventional gene alignment methods.

The computational results have surprised scientists in being able to classify some bacteria and viruses that until now were enigmatic.

The technique, which employs feature frequency profiles (FFP), is described in a paper to appear this week in the early online edition of the journal Proceedings of the National Academy of Sciences.

Current methods for comparing the genomes of different organisms focus on a small set of genes that the organisms being compared have in common. The

Contact: Robert Sanders
University of California - Berkeley

Page: 1 2 3 4 5 6

Related biology news :

1. Supercomputer provides massive computational boost to biomedical research at TGen
2. Penn presents inaugural symposium on applied mathematics and computational science
3. Computational biochemist uncovers a molecular clue to evolution
4. Computational mathematical sciences receives NSF grant for undergraduate research
5. Computational actinide chemistry: Are we there yet?
6. Novel technique changes lymph node biopsy, reduces radiation exposure
7. Novel technique changes lymph node biopsy, reduces radiaiton exposure
8. New technique is quantum leap forward in understanding proteins
9. New edition of laboratory manual includes cutting-edge techniques to study gene regulation
10. Novel technique for fluorescence tomography of tumors in living animals
11. These shells dont clam up: Innovative technique to record human impact on coastal waters
Post Your Comments:
Related Image:
New computational technique allows comparison of whole genomes as easily as whole books
(Date:4/17/2014)... on a novel method to help kidney stone ... effective treatment possible., Kidney stones represent a major ... If left untreated, apart from being particularly painful, ... complications. In many patients treated successfully, stone recurrence ... pathological approach to diagnosis and treatment needs to ...
(Date:4/17/2014)... the genetic information of DNA is used to ... numerous different functions in living organisms. Messenger RNA ... expression, by relating the genetic information of DNA ... , By examining the different types and ... at a given time, researchers can determine which ...
(Date:4/17/2014)... View of Domestication," a special feature of The ... ( PNAS ) published April 29, raises a ... deep history that most of us take for granted. ... in many spots around the globe shifted from hunting ... and plants. , It seems so straightforward and yet ...
Breaking Biology News(10 mins):Rapid and accurate mRNA detection in plant tissues 2Genetic study tackles mystery of slow plant domestications 2Genetic study tackles mystery of slow plant domestications 3Genetic study tackles mystery of slow plant domestications 4
... PHILADELPHIA Saying that the sense of taste is complicated ... so. Exactly how cells transmit taste information to the brain ... pretty much a mystery, until now. , A team of ... main fuel source is released as the neurotransmitter from sweet, ...
... can induce a group of aggressive immune cells that ... is the result of a study conducted by Dr. ... Haven and the Broad Institute of the Massachusetts Institute ... Ralf Linker (Dept. of Neurology, University Hospital Erlangen), Professor ...
... PROVIDENCE, R.I. [Brown University] All too often, stress ... brain research have provided scientists with insight that might ... study in the journal Neuron pinpoints the ... an unprecedented degree. The advance could accelerate progress toward ...
Cached Biology News:How the body's energy molecule transmits 3 types of taste to the brain 2International study: Excess dietary salt may drive the development of autoimmune diseases 2International study: Excess dietary salt may drive the development of autoimmune diseases 3Study pinpoints, prevents stress-induced drug relapse in rats 2Study pinpoints, prevents stress-induced drug relapse in rats 3
(Date:1/14/2014)... 14, 2014 EquitiesIQ, a leading informational ... ALQA). Alliqua is an emerging biomedical company acquiring, developing, ... care market. , Free report download: ... seasoned management team and Board, which launched the company’s ...
(Date:1/14/2014)... and BETHESDA, Md. , ... joining together with two institutes from the National Institutes ... tools for bringing safer, more effective treatments to patients ... National Center for Advancing Translational Sciences (NCATS) and the ...
(Date:1/14/2014)... 14, 2014 In recent years, growing ... methods in product development and promotion has led to ... mistrust, fueled by concerns about the insidious impact of ... of spectacular fines to the world’s biggest pharmas for ...
(Date:1/14/2014)... Rockville, MD (PRWEB) January 14, 2014 ... dedicated to developing innovative information technology solutions for ... other health care stakeholders, announced today the signing ... the US Food and Drug Administration (FDA). ...
Breaking Biology Technology:EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3Global Record Systems Announces Research Collaboration Agreement with FDA to Create a Novel “Big Data” Paradigm for Collection of Patient Safety and Outcomes Information 2
... 2011 Science Applications International Corporation (SAIC) (NYSE: ... David Heimbrook as chief executive officer of SAIC-Frederick, Inc., ... Heimbrook will succeed Dr. Larry Arthur, who has served ... as chief scientist. SAIC-Frederick provides operations and ...
... Pharmaceutical Institute, the leading provider of specialized ... and a subsidiary of Campbell Alliance, today announced ... Excellence® Account Management Suite of e-courses.  The ... managed care account managers by addressing high-priority topics ...
... signifiant step closer following a breakthrough discovery by scientists ... today by the leading scientific journal Proceedings of ... demonstrates for the first time the exact molecular structure ... electrical charge. The discovery means scientists can now ...
Cached Biology Technology:Dr. David Heimbrook Appointed Chief Executive Officer of SAIC-Frederick, Inc. 2Dr. David Heimbrook Appointed Chief Executive Officer of SAIC-Frederick, Inc. 3Account Management Training Suite Delivers Two Key Performance Dimensions 2Discovery opens the door to electricity from microbes 2
... a proteolytic product of ... I which retains polymerization and ... but has lost 5 ->3 ... polymerization fidelity of the holoenzyme ...
... RNase H degrades, as an endoribonuclease, ... DNA hybrids of natural origin, e.g. ... synthetic complexes, e.g. poly(A) x poly(dT). ... and 3-OH termini. Nearly no activity ...
... E. coli strain containing an overproducing clone of ... the formation of a phosphodiester bond between juxtaposed ... DNA or RNA. It repairs single-stranded nicks in ... join both blunt-end and cohesive-end fragments of duplex ...
Goat polyclonal to Haptoglobin ( Abpromise for all tested applications). Antigen: Affinity purified human haptoglobin. Entrez GeneID: 3240 Swiss Protein ID: P00738...
Biology Products: