Navigation Links
New compounds may control deadly fungal infections
Date:12/22/2009

An estimated 25,000 Americans develop severe fungal infections each year, leading to 10,000 deaths despite the use of anti-fungal drugs. The associated cost to the U.S. health care system has been estimated at $1 billion a year.

Now two Syracuse University scientists have developed new brominated furanones that exhibit powerful anti-fungal properties.

The most virulent fungus is Candida albicans, which is carried by about 75 percent of the public. Typically the fungus is harmless but, in individuals with HIV or otherwise compromised immune systems, it can cause candidiasis, which has a high mortality rate. The fungi can also form biofilms that attach to surfaces and are up to 1,000 times more resistant to anti-fungals.

"These new furanones have the potential to control such infections and save lives," says assistant professor Dacheng Ren of the Department of Biomedical and Chemical Engineering in SU's L.C. Smith College of Engineering and Computer Science. "In our tests, they reduced fungal growth by more than 80 percent, and we hope to improve on that going forward."

Ren and his collaborator, chemistry professor Yan-Yeung Luk of SU's College of Arts and Sciences, have filed a non-provisional patent application. They have also published related results in the Journal of Applied Microbiology and Biotechnology.

Over the past 20 years, pathogenic fungi have developed growing resistance to anti-fungal drugs. This stimulated a strong demand for more effective drugs and led to the successful research at Syracuse. The researchers' genomic study suggests that furanones have different genetic targets than current anti-fungal agents and thus may avoid drug resistance acquired in the past. The research team has also shown previously that these furanones inhibit bacterial biofilm formation; thus they may help control chronic infections where biofilms often appear, on surgical, dental and other implants.

Ongoing furanones research at Syracuse University will investigate a broad spectrum of other potential capabilities, ranging from diverse medical uses, such as controlling bacterial and fungal biofilms, to anti-fungal wood preservatives for the building materials market.


'/>"/>

Contact: Sara Miler
semortim@syr.edu
315-443-9038
Syracuse University
Source:Eurekalert

Related biology news :

1. Boron-based compounds trick a biomedical protein
2. Natural compounds, chemotherapeutic drugs may become partners in cancer therapy
3. MSU discoveries upend traditional thinking about how plants make certain compounds
4. Compounds could be new class of cancer drugs
5. Grape-seed extract kills laboratory leukemia cells, proving value of natural compounds
6. 2 new compounds show promise for eliminating breast cancer tumors
7. Two new compounds show promise for eliminating breast cancer tumors
8. Scripps research scientists identify compounds for stem-cell production from adult cells
9. 3-substituted indolones as novel therapeutic compounds for neurodegenerative conditions
10. New $11 million center to speed production of new compounds for drug discovery
11. Discovery of natural compounds that could slow blood vessel growth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/9/2016)... ISTANBUL , June 9, 2016  Perkotek an innovation leader in attendance control ... to seamlessly log work hours, for employers to make sure the right employees are ... Logo - http://photos.prnewswire.com/prnh/20160609/377486LOGO ... ... ...
(Date:6/2/2016)... June 2, 2016 The Department of ... awarded the 44 million US Dollar project, for the ... Plates including Personalization, Enrolment, and IT Infrastructure , ... the production and implementation of Identity Management Solutions. Numerous renowned ... Decatur was selected for the most ...
(Date:5/24/2016)... patient care by providing unparalleled technology to leaders of the medical imaging industry.  As ... added to the range of products distributed by Ampronix. Photo - ... ... ... ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... June 27, 2016   Ginkgo Bioworks , a ... engineering, was today awarded as one of the ... the world,s most innovative companies. Ginkgo Bioworks is ... the real world in the nutrition, health and ... directly with customers including Fortune 500 companies to ...
(Date:6/24/2016)... ... June 24, 2016 , ... Researchers at the Universita Politecnica delle ... people with peritoneal or pleural mesothelioma. Their findings are the subject of a new ... , Diagnostic biomarkers are signposts in the blood, lung fluid or tissue of mesothelioma ...
(Date:6/23/2016)... - FACIT has announced the creation of a ... Propellon Therapeutics Inc. ("Propellon" or "the Company"), to ... of first-in-class WDR5 inhibitors for the treatment of ... an exciting class of therapies, possessing the potential ... patients. Substantial advances have been achieved with the ...
(Date:6/23/2016)... -- The Prostate Cancer Foundation (PCF) is pleased to announce 24 new ... prostate cancer. Members of the Class of 2016 were selected from a pool ... Read More About the Class of 2016 PCF Young Investigators ... ... ...
Breaking Biology Technology: