Navigation Links
New compound may accelerate bone healing, prevent osteoporosis

INDIANAPOLIS -- An Indiana University scientist studying human bone growth has received a $2.6 million grant from the U.S. Department of Defense to study a chemical compound with potential to fight osteoporosis and accelerate broken bone healing.

Hiroki Yokota, professor of biomedical engineering at Indiana University-Purdue University Indianapolis (IUPUI) and adjunct professor of anatomy and cell biology at the IU School of Medicine, will investigate the effect of salubrinal -- a chemical compound originally developed to encourage insulin production in individuals with diabetes -- on human bone strength and growth. Early laboratory research supported by the Indiana Clinical and Translational Sciences Institute (CTSI) suggests weakened bones treated with salubrinal experience a statistically significant increase in strength, as well as accelerated healing in bones that have been fractured.

"People are getting older," Yokota said, "and when people get older, particularly women, they tend to develop osteoporotic bones. As a mechanical engineer, I was originally exploring mechanical stimulation, which is similar to exercise, to strengthen bones. But by studying these mechanisms, I came across a molecular pathway that became the beginning of this discovery."

Acute pelvic and hip fractures account for about 350,000 hospitalizations each year in the United States, with 76 percent of patients being female and annual cases expected to reach 650,000 by 2050. Moreover, Yokota said approximately 25 percent of fracture patients previously living independently require full-time nursing care post-fracture, with only a quarter returning to pre-injury levels of activity and half never fully recovering.

Older populations are increasingly affected by weakened and broken bones as aging cells are no longer able to produce sufficient levels of collagen, the protein from which bones derive their strength. Salubrinal prevents this cellular decline by strengthening the body's "protein-producing machinery," which creates collagen and keeps bones strong.

"In preliminary studies, particularly in bone fractures, we've see an effect in as little as a week," said Yokota, "and the effect is even stronger in two weeks. We're not ready to cite numbers, but I can say it appears significant."

The process by which salubrinal heals fractures may also apply to type 2 diabetes, the disease for which salubrinal was originally conceived.

"Salubrinal stimulates a cellular 'rescue program' in response to stress," said Yokota, noting some diabetes may be caused by the pancreas killing insulin-producing eyelet cells in response to increased insulin needs -- a process similar to the cellular shutdown that can occur in bones overtaxed by collagen production.

"With this drug," Yokota said, "the cells just enjoy the body's rescue response without really experiencing any new negative pressure. Using salubrinal is basically about trying to treat cells a little better."

The Department of Defense grant will support continued research into the effectiveness of salubrinal on broken and weakened bones and contribute to determining dosing guidelines, said Yokota, with an eye toward moving the drug into early clinical trials for patients with osteoporosis or bone fractures.

"In a sense, step one is done," he said. "This support will move us towards step two."

Developing a pill from the compound's current, injectable form -- making it easier to administer as well as increase its potential marketability -- is also a priority.

Altogether, Yokota sets an ambitious agenda.

"Our ultimate goal is FDA approval to provide a safe, efficacious, easy-to-use drug therapy that will heal hip fractures in the geriatric population," he said.

Additional support for Yokota's other projects related to bone strength and growth comes from the National Institutes of Health and the National Aeronautics and Space Administration, which has invested in his research for its potential to reduce bone loss experienced by astronauts due to weightlessness.

The Indiana CTSI provided key support to Yokota's early investigation into salubrinal with a $20,000 Research Inventions and Scientific Commercialization Grant. The funds fueled research identifying a chemical partner that combines with the salubrinal to create a safe, non-toxic drug easily absorbable by the human body. The early study also benefitted from a program managed by the Indiana CTSI, in partnership with the IU Kelley School of Business, which partners investigators looking to turn their discoveries into viable startup projects with MBA students seeking real-life experience in the business of life science.


Contact: Kevin Fryling
Indiana University

Related biology news :

1. Duke team finds compounds that prevent nerve damage
2. Argonne scientists peer into heart of compound that may detect chemical, biological weapons
3. Discovery of natural compounds that could slow blood vessel growth
4. LSUHSC awarded patent for compound inhibiting cancer and other diseases
5. Resveratrol, red wine compound linked to health, also found in dark chocolate and cocoa
6. Design of a compound that stabilizes the main natural suppressor of tumors
7. New $11 million center to speed production of new compounds for drug discovery
8. 3-substituted indolones as novel therapeutic compounds for neurodegenerative conditions
9. Scripps research scientists identify compounds for stem-cell production from adult cells
10. Two new compounds show promise for eliminating breast cancer tumors
11. 2 new compounds show promise for eliminating breast cancer tumors
Post Your Comments:
Related Image:
New compound may accelerate bone healing, prevent osteoporosis
(Date:4/26/2016)... Research and Markets has announced ... 2016-2020"  report to their offering.  , ,     (Logo: ... analysts forecast the global multimodal biometrics market to ... period 2016-2020.  Multimodal biometrics is being ... the healthcare, BFSI, transportation, automotive, and government for ...
(Date:4/15/2016)... 15, 2016  A new partnership announced today ... underwriting decisions in a fraction of the time ... and high-value life insurance policies to consumers without ... With Force Diagnostics, rapid testing (A1C, Cotinine and ... (blood pressure, weight, pulse, BMI, and activity data) ...
(Date:4/14/2016)... April 14, 2016 BioCatch ... Detection, today announced the appointment of Eyal Goldwerger ... role. Goldwerger,s leadership appointment comes at a ... of the deployment of its platform at several of ... technology, which discerns unique cognitive and physiological factors, is ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 2016 /PRNewswire/ - FACIT has announced the creation ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" or "the ... a portfolio of first-in-class WDR5 inhibitors for the ... WDR5 represent an exciting class of therapies, possessing ... for cancer patients. Substantial advances have been achieved ...
(Date:6/23/2016)... YORK , June, 23, 2016  The Biodesign ... to envision new ways to harness living systems and ... Modern Art (MoMA) in New York City ... than 130 participating students, showcased projects at MoMA,s Celeste ... Paola Antonelli , MoMA,s senior curator of architecture ...
(Date:6/23/2016)... , June 23, 2016 Apellis ... Phase 1 clinical trials of its complement C3 ... single and multiple ascending dose studies designed to ... (PD) of subcutaneous injection in healthy adult volunteers. ... (SC) either as a single dose (ranging from ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... regulatory and technical consulting, provides a free webinar on Performing Quality ... 13, 2016 at 12pm CT at no charge. , Incomplete investigations are still ...
Breaking Biology Technology: