Navigation Links
New compound excels at killing persistent and drug-resistant tuberculosis
Date:6/17/2013

s own killed more than 99.9% of ordinary, actively replicating TB bacteria within three weeks, and in combination with isoniazid or rifampin, could kill 100% within that period. TCA1 also showed strong effectiveness against drug-resistant TB strains, removing all signs of one common strain within a week when combined with isoniazid. Against a highly fatal "super-bug" strain from South Africa, which resists all conventional TB drugs, the new compound on its own had a kill rate of more than 99.999% within three weeks.

As expected, TCA1 also showed potent effects against non-replicating TB. Tests in mice confirmed TCA1's effectiveness and suggested that the combination of TCA1 and isoniazid could be more powerful than existing drug regimens. TCA1 showed no sign of toxicity or adverse side effects in cell culture and mouse experiments, and also showed almost no tendency to induce drug resistance in TB.

A Complex Mechanism

Working with the laboratories of Gurdyal S. Besra and Klaus Ftterer at the University of Birmingham, UK, Katarina Mikusova at Comenius University in Slovakia, and Kai Johnson at Ecole Polytechnique Fdrale de Lausanne (EPFL) in Switzerland, the team next did structural and biochemical analyses to determine how the new compound kills Mtb so efficiently.

The researchers found it works in an apparently unique way, largely by targeting two Mtb enzymes, one supporting TB replication and the other TB dormancy and persistence. "I don't know of any other antibiotic that kills replicating bacteria through one pathway and non replicating bacteria through another, as this one does," Wang said.

Now funded by the Global Alliance for TB Drug Development, Wang and his colleagues are working to devise improved variants of TCA1. "We already have analogs of TCA1 that are more potent and look very promising as TB drug candidates," said Wang.

Assuming that preclinical tests are completed successfull
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. First dual-action compound kills cancer cells, stops them from spreading
2. UCI researchers find sea anemone venom-derived compound effective in anti-obesity studies
3. University of Wisconsin chemists find new compounds to curb staph infection
4. The compound in the Mediterranean diet that makes cancer cells mortal
5. Scientists map all possible drug-like chemical compounds
6. Compound stimulates tumor-fighting protein in cancer therapy
7. Beers bitter compounds could help brew new medicines
8. New compound overcomes drug-resistant Staph infection in mice
9. Promising compound restores memory loss and reverses symptoms of Alzheimers
10. A new breed of stable anti-aromatic compound
11. Compound in grapes, red wine could be key to fighting prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... vision specialist at The University of Texas Health Science ... a grant to help Harris County residents whose vision ... , Even with corrective lenses, many people with low ... a variety of low vision devices, such as telescopes, ... loss. , Iyer is using the three-year, $164,645 SightFirst ...
(Date:7/24/2014)... The Atlantic Forest is a hotspot of biodiversity and ... (frogs, tree-frogs, and toads) in the world. However, current ... past few years has been an increase in the ... with the advance of molecular techniques and availability of ... extensive number of samples for molecular and morphological analysis, ...
(Date:7/24/2014)... N.J. A yearlong study funded by the New ... Edward J. Bloustein School of Planning and Public Policy ... in Sandy-affected towns are skeptical about the likelihood of ... survey respondents, 45 percent indicated they were "pessimistic" or ... by Superstorm Sandy would be rebuilt better than they ...
Breaking Biology News(10 mins):UTHealth Dr. Bhavani Iyer awarded low vision grant 2A tiny new species of frog from Brazil with a heroic name 2Rutgers study explores attitudes, preferences toward post-Sandy rebuilding 2
... China, September 12, 2013BGI Tech Solutions Co., LTD, ... largest genomics research organization, and South Texas Accelerated ... collaborating on the San Antonio 1000 Cancer Genome ... link genetic alterations that underlie different cancers to ...
... Society of America (ESA) is proud to announce ... Grants. These travel grants, which will help entomology ... in Austin this November are funded by ... Plant-Associated Insects and Nematodes. The grants were created ...
... A tiny number of Asian carp could establish a ... to new research from the University of Waterloo. , Published ... from Professor Kim Cuddington of the Faculty of Science at ... with the introduction of 20 fish into the Great Lakes, ...
Cached Biology News:BGI and START initiate collaboration to advance unique San Antonio 1000 Cancer Genome Project 2BGI and START initiate collaboration to advance unique San Antonio 1000 Cancer Genome Project 3Entomological Society of America names winners of 2013 student travel grants 2Entomological Society of America names winners of 2013 student travel grants 3Entomological Society of America names winners of 2013 student travel grants 4Entomological Society of America names winners of 2013 student travel grants 5Entomological Society of America names winners of 2013 student travel grants 6Entomological Society of America names winners of 2013 student travel grants 7Entomological Society of America names winners of 2013 student travel grants 8Tiny number of Asian carp could be big problem for the Great Lakes 2
(Date:7/24/2014)... Calif. , July 24, 2014  Asterias ... in the emerging field of regenerative medicine, announced ... of a presentation to investors on Tuesday, July ... PDT.  The presentation will include an overview of ... access the webcast, visit http://www.ustream.tv/channel/asterias-biotherapeutics at ...
(Date:7/24/2014)... group leader Yung-Eun Sung has announced that they ... nitrogen-doped graphenes which can be applied as high ... Yung-Eun Sung is both a group leader at ... Basic Science* (IBS) and a professor at the ... significance with regards to the development of relative ...
(Date:7/24/2014)... synthetic processes prefer to settle into equilibriuma state ... within the realm of non-equilibrium conditions where new ... energy and phases, such as temperature fluctuations, freezing ... to regulate their body temperature, airplanes to fly, ... , But even though these conditions exist ...
(Date:7/24/2014)... California (PRWEB) July 24, 2014 ... to advances in modeling lithium-ion battery storage capacity. ... benefit from a theoretical model created at ... University that predicts how carbon components will ... energy storage emphasizes the urgent need for higher-performance ...
Breaking Biology Technology:Asterias Biotherapeutics Announces Live Investor Webcast 2Asterias Biotherapeutics Announces Live Investor Webcast 3Asterias Biotherapeutics Announces Live Investor Webcast 4New approach to form non-equilibrium structures 2Getting More Life out of Lithium-ion Batteries 2
... , , WATERTOWN, Mass., Sept. 10 ... breakthrough synthetic chemistry technology announced today that it will ... on the synthesis and antibacterial activity of analogs from ... at the 49th Interscience Conference on Antimicrobial Agents and ...
... STOCKHOLM, September 10 Pergamum AB has announced ... wound healing interests, and create a broad-based therapeutic ... The Pergamum product pipeline consists of five ... Indications covered within the,portfolio include improved wound healing ...
... , , , ... Inc. (PTC) today announced the initiation of a Phase 3 ... in patients with nonsense mutation cystic fibrosis (nmCF). Patients ... conductance regulator (CFTR) protein, a chloride channel necessary for normal ...
Cached Biology Technology:Tetraphase Presents Study Results for Novel Classes of Antibiotics from its Breakthrough Synthetic Chemistry Platform at ICAAC 2009 2Pergamum to Provide Effective Development of Innovative Dermatology and Wound Healing Companies 2PTC Therapeutics Initiates Registration-Directed Phase 3 Trial of Ataluren in Cystic Fibrosis 2PTC Therapeutics Initiates Registration-Directed Phase 3 Trial of Ataluren in Cystic Fibrosis 3PTC Therapeutics Initiates Registration-Directed Phase 3 Trial of Ataluren in Cystic Fibrosis 4PTC Therapeutics Initiates Registration-Directed Phase 3 Trial of Ataluren in Cystic Fibrosis 5PTC Therapeutics Initiates Registration-Directed Phase 3 Trial of Ataluren in Cystic Fibrosis 6
Human VASA Biotinylated Affinity Purified PAb...
Recombinant Mouse Matrilin-4, CF Protein Family: Extracellular Matrix Molecules, Chondrogenesis Markers...
An instrument that delivers an accurate and uniform amount of light energy to cells to photoactivate csiRNA products....
Use the DUALmembrane kit 3 to carry out DUALmembrane interaction analysis and cDNA library screening to characterize interactions between integral membrane proteins and to identify novel interaction ...
Biology Products: