Navigation Links
New compound excels at killing persistent and drug-resistant tuberculosis
Date:6/17/2013

LA JOLLA, CA June 17, 2013 An international team led by scientists at The Scripps Research Institute (TSRI), the Howard Hughes Medical Institute and Albert Einstein College of Medicine of Yeshiva University has identified a highly promising new anti-tuberculosis compound that attacks the tuberculosis (TB) bacterium in two different ways.

"These findings represent an effort to help solve one of the major global health crises of our timethe resurgence of TB and its dangerous drug-resistant strains," said Peter G. Schultz, the Scripps Family Chair Professor of Chemistry at TSRI, who was senior author of the study with William R. Jacobs, Jr., member of the Howard Hughes Medical Institute and professor of microbiology & immunology and of genetics at Albert Einstein College of Medicine.

"In cell cultures and in mice, this compound showed powerful activity against ordinary active TB bacteria, non-replicating TB bacteria and even extensively drug-resistant TB strains," said Feng Wang, a member of the Schultz lab at TSRI and first author of the study with Dhinakaran Sambandan of the Jacobs lab and Rajkumar Halder of the Schultz lab.

The paper appears in this week online ahead of print in an Early Edition of the Proceedings of the National Academy of Sciences.

Global Health Crisis

Although isoniazid and rifampin, the two front-line TB drugs, came into use in 1952 and 1967 respectively, new TB infections still occur at the rate of roughly one per second. At any moment about a third of the existing human population is infectedmostly with inactive, latent TB, although active TB still kills over one million people each year. Russia, Africa, China and Southeast Asia have been especially hard hit by the epidemic.

Increased urbanization, public health complacency and immunity-weakening HIV have been major enablers of TB's spread in recent decades. But the bacterium that causes TBMycobacterium tuberculosis<
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. First dual-action compound kills cancer cells, stops them from spreading
2. UCI researchers find sea anemone venom-derived compound effective in anti-obesity studies
3. University of Wisconsin chemists find new compounds to curb staph infection
4. The compound in the Mediterranean diet that makes cancer cells mortal
5. Scientists map all possible drug-like chemical compounds
6. Compound stimulates tumor-fighting protein in cancer therapy
7. Beers bitter compounds could help brew new medicines
8. New compound overcomes drug-resistant Staph infection in mice
9. Promising compound restores memory loss and reverses symptoms of Alzheimers
10. A new breed of stable anti-aromatic compound
11. Compound in grapes, red wine could be key to fighting prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/s6qzt5/samsung_galaxy_s5 ) ... Galaxy S5 - Home Button Synaptics Fingerprint Sensor ... http://photos.prnewswire.com/prnh/20130307/600769 ... the iPhone 5S, Samsung introduces for the first ... The Galaxy S5 home button presents an ...
(Date:12/17/2014)... , Dec. 16, 2014  Automation is ... this more evident than at international borders. Over ... document scanners have allowed veteran travelers to self ... Passport Control (APC) Kiosks at an increasing number ... globe. According to Maxine ...
(Date:12/11/2014)... PAUL, Minn. , Dec. 10, 2014 /PRNewswire/ ... wireless physiologic monitoring, has released a new series ... needs of preclinical toxicology researchers. M series, part ... help toxicologists collect the best possible physiologic data ... Adding functional endpoints to toxicology studies ...
Breaking Biology News(10 mins):Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2New telemetry implants expected to change how large animal toxicology studies are conducted 2
... therapy of cancer can be improved to be much more ... University Medical Center,s Lombardi Comprehensive Cancer Center in the March ... that antibody therapy has the capacity to immunize people against ... at GUMC and an internationally recognized expert in development and ...
... published results of a new study into plant sex ... of male,. The study takes to a new level ... seed production. Professor David Twell and colleagues in the ... discovery of a gene that has a critical role in ...
... CO, USA The Geological Society of America presents a ... Idaho, and Its Catchment . This volume is the culmination ... a holistic understanding of the long-lived Bear Lake, which is ... course of the Bear River, the largest river in the ...
Cached Biology News:Lombardi research: Monoclonal antibodies primed to become potent immune weapons against cancer 2Lombardi research: Monoclonal antibodies primed to become potent immune weapons against cancer 3Plant biologists discover gene that switches on 'essence of male' 2
(Date:12/22/2014)... Dec. 22, 2014  ( www.competitivehealth.com ) — Competitive ... medical bill review and advocacy service, has signed an ... WellCard Savings discount health services marketplace. 63% ... more than they expected to pay. As part of ... costs, WellCard Savings is pleased to offer medical bill ...
(Date:12/22/2014)... 22, 2014 Fertility Associates of Memphis ... Bank USA , a network of more than 20 ... partnership, patients have fast access to a national pool ... IVF . Fertility Associates of Memphis is the only ... treatment option. , Dr. William Kutteh , director ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
(Date:12/19/2014)... Dec. 19, 2014 Bina Technologies, Inc. (Bina, ... that they have been acquired by Roche (SIX: RO, ... privately held company that provides a big data platform ... (NGS) data for the academic and translational research markets. ... and will continue to focus on development of their ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... Fla., Feb. 22, 2011 Seventy-two start ups, 2,500 ... three new ways to measure the progress of Indiana,s ... and important part of the state,s economy.  ... a new report, From Dishwashers to Digital Medical ...
... Qteros, Inc., the developer of a unique and ... the lowest-cost production of cellulosic ethanol, today announced its ... A. McCarthy, Jr., Qteros, President and Chief Executive Officer, ... 11th Global Clean Technology Conference being held at the ...
... Otonomy, Inc., a developer of innovative therapeutics for ... positive results for the company,s lead product candidate, ...  Data demonstrated that a single intratympanic (IT) injection ... the corticosteroid dexamethasone, provided significant protection against both ...
Cached Biology Technology:Advancing Patient Care and Driving Economic Impact, Indiana's Health Information Technology Innovation Cluster Serves as National Model 2Advancing Patient Care and Driving Economic Impact, Indiana's Health Information Technology Innovation Cluster Serves as National Model 3Advancing Patient Care and Driving Economic Impact, Indiana's Health Information Technology Innovation Cluster Serves as National Model 4Qteros Management to Present at Alternative Energy Investment Banking Conferences 2Otonomy's OTO-104 Demonstrates Hearing Loss Protection and Hearing Recovery in Preclinical Studies 2Otonomy's OTO-104 Demonstrates Hearing Loss Protection and Hearing Recovery in Preclinical Studies 3
... Simplify the process and you reduce the ... into the CEQ 8000. Developed using Beckman ... leadership in capillary electrophoresis technology, the CEQ ... system. This system automatically fills the capillary ...
... standard electrophoresis hood is a ... systems. Placed on the transilluminator, ... place and provides a darkroom ... the lab bench. This 13 ...
... Zyagen tissue microarrays are derived from ... to rigorous quality control procedures to ensure ... are manually assembled in one block, sectioned ... mounted on coated slides. Sections are large ...
... Zyagen tissue microarrays are derived from Paraffin ... rigorous quality control procedures to ensure the ... manually assembled in one block, sectioned at ... on coated slides. Sections are large (3-5 ...
Biology Products: