Navigation Links
New compound could reverse loss of muscle mass in cancer and other diseases
Date:12/19/2013

A new antibody could dramatically boost strength and muscle mass in patients with cancer, chronic obstructive pulmonary disease (COPD), sporadic inclusion body myositis, and in elderly patients with sarcopenia according to research published ahead of print in the journal Molecular and Cellular Biology.

"Age-related loss of muscle mass is a major contributing factor to falls, broken bones, and the loss of mobility," says co-corresponding author David Glass of Novartis, Cambridge, MA, one of the compound's developers, along with first author Estelle Trifilieff, also of Novartis. "This study illustrates that we may have a powerful tool to prevent muscle wasting and promote growth."

The new compound (BYM338) acts to prevent muscle wasting by blocking a receptor that engages a cellular signaling system that exists to put the brakes on muscle development when appropriate. But sometimes those brakes are activated inappropriately, or are stuck on.

"Our goal was to release the brakes," says Glass.

A variety of signals can activate the receptor. Prior to development of BYM338, compounds developed to block these molecules were blunt instruments, either trapping all incoming signals (which stimulated muscle growth but also caused harmful side effects) or blocking just a single receptor activator (providing only tepid growth stimulation.) BYM338 was designed to be in the Goldilocks zone (just right.)

In the study the compound boosted muscle mass 25 to 50 percent and increased strength in animal models. Those gains were significantly superior to those of compounds that blocked a single receptor activator. Clinical trials are currently underway.

The conditions BYM338 is designed to treat are losses of skeletal muscle and fat, which are not reversed by simply eating more, and are known as cachexias when associated with certain chronic illnesses. Cancer cachexia develops in a majority of patients with advanced
'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Canadian girl, 16, invents disease-fighting, anti-aging compound using tree particles
2. Biosensor illuminates compounds to aid fight against TB
3. New screening technique yields elusive compounds to block immune-regulating enzyme
4. Sulphur and iron compounds common in old shipwrecks
5. Heparin-like compounds inhibit breast cancer metastasis to bone
6. Like curry? New biological role identified for compound used in ancient medicine
7. Nuisance seaweed found to produce compounds with biomedical potential
8. Dont feel like exercise? Scientists find compound that may help you work out harder
9. New drug-screening method yields long-sought anti-HIV compounds
10. Nonstoichiometric Compounds V - An ECI Conference Series
11. New compound holds promise for treating Duchenne MD, other inherited diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2015)... Calif. , April 20, 2015 Huntington ... Gabriel Valley to implant a new miniaturized, wireless monitoring ... System is the first and only FDA-approved heart failure ... hospital admissions when used by physicians to manage heart ... sensor that is implanted in the pulmonary artery (PA) ...
(Date:4/13/2015)... According to a recently ... & Opportunities, 2020", the global biometrics market is ... till 2020. The biometrics market is garnering attention ... review of biometric management systems. The constant development ... greater efficiency, are resulting in increasing installation of ...
(Date:4/6/2015)... , Apr. 6, 2015 NXT-ID, Inc. ... a biometric authentication company focused on the growing ... filed provisional patent 62/143028 for MINIATURE, ... ENERGY TRANSFER  NXT-ID introduces a new ... This patent surrounds the use of miniature antenna ...
Breaking Biology News(10 mins):Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4
... demand for cargo transport, has inadvertently opened the flood ... has mapped the most detailed forecast to date for ... of cargo ships. Scientists from the Universities of ... data and biological records to assess the risk of ...
... the quality of life for many cancer patients. Many ... to DNA. The public has an opportunity to learn ... drugs and how laboratory research may lead to novel targets ... , a professor of chemistry at the University ...
... May 3, 2013 In a climate as prone ... heat, light and cool. Fortunately, innovative solutions are being ... Network (SNEBRN), a nationwide university initiative headquartered at Concordia, ... from Natural Resources Canada (NRCan). "Through the ...
Cached Biology News:Researchers calculate the global highways of invasive marine species 2Researchers calculate the global highways of invasive marine species 3How do anticancer drugs work? 2How do anticancer drugs work? 3$1 million for smart energy solutions 2
(Date:5/21/2015)... As part of its philanthropic partnership with Banner ... funded a $3.25 million project to relocate and equip ... up-to-date features and technology. , The new pharmacy is ... members will begin moving from the current location to ... , The current pharmacy has been using a ...
(Date:5/21/2015)... 2015 /PRNewswire/ - RepliCel Life Sciences Inc. (TSX.V: ... company focused on the development of autologous cell ... the International Society for Cellular Therapy (ISCT) on ... currently in a Phase 1/2 clinical trial.  The ... from 5:30 PM to 7:00 PM local time, ...
(Date:5/21/2015)... May 21, 2015 Tunnell Consulting, ... the firm as senior statistician and Principal, a position ... experience in the management and analysis of complex and ... chemical industries. , “We’re delighted to have Julia join ... data analytics,” said Dr. Philippe Cini, Group Vice President ...
(Date:5/20/2015)... , May 20, 2015 Research and Markets ... of the "Top Technologies in HW_Technical Insights" ... of this report evaluated technology trends in the Health ... that are likely to have an impact in the ... analysis of the top 10 health and wellness technologies ...
Breaking Biology Technology:Sun Health Foundation Provides $3.25M to Expand, Relocate Banner Del E. Webb Medical Center Pharmacy 2Sun Health Foundation Provides $3.25M to Expand, Relocate Banner Del E. Webb Medical Center Pharmacy 3RepliCel to Present Unique Autologous Cell Treatment for Achilles Tendinosis at International Society for Cellular Therapy Conference 2RepliCel to Present Unique Autologous Cell Treatment for Achilles Tendinosis at International Society for Cellular Therapy Conference 3Julia O’Neill Joins Tunnell Consulting’s Operational and Process Improvement Practice 2Top Technologies in the Health and Wellness Industry 2015 2
... 8 A study in the June issue of ... demonstrates that the Hepascore(TM) liver fibrosis blood-serum test panel ... fibrosis in patients with chronic hepatitis C (HCV), potentially ... care for staging fibrosis, in a particular subset of ...
... Interactive Agency Recognized for Excellence in Healthcare Marketing , ... Group , the premier strategic interactive marketing agency serving ... the 2009 Aster Awards with the ... healthcare marketing campaigns for DePuy Orthopaedics and AstraZeneca. ...
... , Amerinet Offering AccuVein,s AV300 Hand-Held Vein Illumination Device to ... June 8 AccuVein LLC today announced a three year ... world,s first hand-held, non-contact vein illumination device to its members. ... a patient,s skin revealing vein position to help the healthcare ...
Cached Biology Technology:Study Finds Noninvasive Blood Test for Liver Fibrosis May Alleviate Need for Liver Biopsies for Some Patients with Chronic Hepatitis C 2Study Finds Noninvasive Blood Test for Liver Fibrosis May Alleviate Need for Liver Biopsies for Some Patients with Chronic Hepatitis C 3Study Finds Noninvasive Blood Test for Liver Fibrosis May Alleviate Need for Liver Biopsies for Some Patients with Chronic Hepatitis C 4Cadient Group Brings Home the Gold and Two Bronze Aster Awards 2AccuVein Inks National Three-Year Group Purchasing Deal With Amerinet 2
...
Mouse monoclonal [IFR0104] to Salmonella enteriditis ( Abpromise for all tested applications)....
Marmoset plasma and serum - various quantities available...
Natural Mouse Laminin is purified from the Engelbreth-Holm-Swarm (EHS) sarcoma and is provided in Tris-buffered saline....
Biology Products: