Navigation Links
New clues to how cancer-related proteins plasmin, thrombin lose inhibition
Date:10/19/2010

proteins could reveal how cancer flourishes, providing a better understanding of the disease and insights into how to attack it.

To investigate cellular shrapnel, the team acquired blood samples from 15 breast cancer patients that spanned cancer stages from I to III. They combined all 15 samples to increase the odds of finding useful information. They also collected blood from 15 control healthy volunteers and treated the samples in the same way.

To examine just the smallest-sized cast-off protein remnants, the researchers removed the blood cells and the dozen most abundant proteins from the blood. Then they collected only the smallest protein pieces, many of which are about a tenth the size of common human proteins. The researchers called this collection of degraded pieces the plasma degradome.

Using proteomics methods at EMSL, DOE's Environmental Molecular Sciences Laboratory on the PNNL campus, the team identified the protein fragments in the cancer and healthy degradomes. The fragments between samples differed significantly. For example, cancer blood held fragments from more than 70 different proteins that were chopped into more than 800 pieces. Healthy blood only held 50 different proteins cut up into more than 400 pieces. In addition, the complement of fragments overlapped some between the cancerous and healthy, but not entirely.

Broken brakes

Different sets of fragments could indicate that cancers found new ways to cut old proteins, but an analysis showed that this was not the case. The key distinction the researchers found was in how often certain proteins were cut at individual sites -- these differed tremendously. In addition, the proteins most likely to be chopped-up in the cancer samples seemed to fall into known cancer-related protein families.

"We were surprised because we expected random changes to the degradome," said lead author, PNNL biologist Yufeng Shen. "But instead we found a cluster
'/>"/>

Contact: Mary Beckman
mary.beckman@pnl.gov
509-375-3688
DOE/Pacific Northwest National Laboratory
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Scientists reveal important clues to how bacteria and viruses are identified as enemies
2. Proteins to yield new clues in fight against osteoporosis
3. Genetic clues to evolution of jaws in vertebrates unearthed by CU-led team
4. Humanized mice may provide clues to better prevent and treat typhoid fever
5. Ecologists find new clues on climate change in 150-year-old pressed plants
6. UT professor uncovers clues into how viruses jump from hosts
7. Ancient Hawaiian glaciers reveal clues to global climate impacts
8. Scientists discover clues to inflammatory disease
9. Molecular biology provides clues to health benefits of olive oil
10. Left or right? Early clues to soccer penalty kicks revealed at Rensselaer Polytechnic Institute
11. Life on Mars: University of Leicester to detect clues for alien existence
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... , July 3, 2014 Research ... addition of the "Global Gesture Recognition & ... - Forecasts to 2020" report to their ... Global Gesture Recognition & Touch-Less Sensing Market ... around for a while, but the companies were ...
(Date:7/10/2014)... 2014 According to a new ... Control Systems Market Global Forecast, Market Share, Size, Growth ... Access Control systems market was valued at USD 15,406.1 ... a CAGR of 12.6% from 2014 to 2019, to ... 2019. Browse the full Electronic Access Control ...
(Date:7/10/2014)... 2014  Acuity Market Intelligence today released forecasts from "The ... that the global market for National Electronic ID (eID) programs ... During this time, the number of National eID cards in ... Asia , with its vast population, will dominate ... issued, while Europe trails a distant ...
Breaking Biology News(10 mins):Global Gesture Recognition & Touch-Less Sensing (2D, 3D, Ultrasonic, IR, Capacitive) Market - Forecasts to 2020 2Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 2Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 3Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 4Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 5National Electronic ID Programs Generate $54 Billion Between 2013 and 2018 with 3.5 Billion National eID Card Holders Worldwide 2
... green chemical technologies will play a key role helping ... a wider range of products from biorefineries, according to ... Director of the University,s Green Chemistry Centre of Excellence, ... the American Association for the Advancement of Science (AAAS) ...
... Feb. 18, 2011 USDA,s National Institute of Food ... (CAP) representing a major scientific investment in studying the ... NIFA Director Roger Beachy made the announcement today at ... Advancement of Science in Washington, D.C. "Climate change ...
... the first time been cloned as seeds. The research by ... 18 in the journal Science , is a major ... traits from generation to generation. Most successful crop ... biology at UC Davis and an author of the paper. ...
Cached Biology News:NIFA announces grants to study the effects of climate change on agricultural and forest production 2NIFA announces grants to study the effects of climate change on agricultural and forest production 3Plants cloned as seeds 2
(Date:7/10/2014)... (PRWEB) July 10, 2014 Unraveling life’s ... together. The Archer Family purchased a DNA ... DNA, but ended up with a lifetime of memories, ... within the family members’ DNA genuinely brought the family ... to search deeper into genetic history and prior to ...
(Date:7/10/2014)... 10, 2014 Senior supply chain management ... associations, addressed the challenges of “Reducing Cost, Lead Time, ... through strategic sourcing. Describing the partnership of the Bio ... Chain Management Institute ( SCMI) of the University ... 24 at the Kroc Institute of Peace and Justice ...
(Date:7/10/2014)... 2014 /PRNewswire-iReach/ -- Tute Genomics, the leader ... an agreement with Lineagen, Inc., to provide ... Dx PLUS.  Lineagen, focused on the ... currently offers FirstStep Dx PLUS, a ... by healthcare providers as a first-line genetic ...
(Date:7/10/2014)... University of Adelaide research may help in the fight ... can detect tiny quantities of explosives with the use ... the journal Sensors and Actuators B: Chemical , ... can detect explosives in concentrations as low as 6.3 ... of only a few minutes. , "Traditionally explosives detection ...
Breaking Biology Technology:Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4Detecting trace amounts of explosives with light 2
... Doping may be a no-no for athletes, but researchers ... was key in getting unprecedented power conversion efficiency from ... Graphene solar cells are one of industry,s great ... future. But previous attempts to use graphene, a single-atom-thick ...
... 25, 2012  Oncobiologics, Inc. announced today that it ... biopharmaceutical industry experts. Stephen J. McAndrew, Ph.D. is ... Benn, Ph.D. has joined the company as Vice ... announced its new Scientific Advisory Board, which will ...
... 24, 2012  For years, doctors and microbiologists have sent ... body for examination. These tests take days to get ... Donald Spector, a well-known, serial entrepreneur-inventor and Chairman of ... few institutionally accredited schools of Acupuncture and Massage Therapy ...
Cached Biology Technology:University of Florida physicists set new record for graphene solar cell efficiency 2Oncobiologics Fills Key Leadership Positions and Names Scientific Advisory Board 2Oncobiologics Fills Key Leadership Positions and Names Scientific Advisory Board 3College Chairman And Prolific Inventor Develops Life-Saving, Real-Time Diagnostic Technologies 2College Chairman And Prolific Inventor Develops Life-Saving, Real-Time Diagnostic Technologies 3
Request Info...
... include: ,ICC and IHC Protocol Development ... ,Antibody Screenings in Animal or Human ... of Cells and Tissues ,Peroxidase, Alkaline ... Fluorescent, or Electron Microscopy ,Protein Localization ...
Request Info...
Request Info...
Biology Products: