Navigation Links
New clues about the basis of muscle wasting disease
Date:3/12/2010

g that changes in this pathway may be a major factor in actin-based nemaline myopathy and that this area could be used to develop therapies for patients.

Nemaline myopathies are sometimes called rod body myopathies as the damaged proteins form abnormal thread-like rods, called nemaline bodies, in the muscle cells. There are a number of different types of rod myopathies and they affect both males and females. In the majority of cases (90%) the condition becomes apparent at birth or early childhood, although in very rare cases, it does not become apparent until adulthood. Rod myopathies are estimated to affect 1 in 50,000 individuals.

Commenting on the findings, Professor Machesky said, "More research now needs to be done to determine whether cells in patients have the same changes that we saw in cells in the laboratory. We used the drugs Jasplakinolide and Cytochalasin D, which target the actin-MAL complex, to reverse the effects of the mutant actin - but these drugs are toxic at high levels as they also disrupt the actin filaments and thus the cell's structure. If they could be modified or used at low concentrations they may prove useful leads to drug development."

Marita Pohlschmidt director of research at the Muscular Dystrophy Campaign said, "Nemaline myopathy is a very rare condition that can be difficult to diagnose, because it is caused by a defect in one of several genes. The research presented in this paper is an important contribution to understanding what causes the muscle wasting in about a fifth of all people affected with this devastating condition. The results will be vital for the future development of treatments for those affected by nemaline myopathy."


'/>"/>

Contact: Dianne Stilwell
diannestilwell@me.com
44-020-897-76510
Biochemical Journal
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study begins to reveal clues to the cause and progression of sepsis
2. Chlamy genome holds clues for renewable energy, the environment and human health
3. How schizophrenia develops: Major clues discovered
4. Tiny fish can yield big clues to Delaware River health
5. Fossils excavated from Bahamian blue hole may give clues of early life
6. Study uncovers clues to cystic fibrosis gene dysfunction and gastrointestinal disease
7. Cornell researcher seeks clues to how tuberculosis infects cells
8. Cognitive, genetic clues identified in imaging study of alcohol addiction
9. HIV isolate from Kenya provides clues for vaccine design
10. Mummy lice found in Peru may give new clues about human migration
11. Tomato pathogen genome may offer clues about bacterial evolution at dawn of agriculture
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... Nov. 20, 2014 Strict laws against distracted ... piloting the North American and European automotive sector towards ... gesture recognition systems that are intuitive and able to ... the industry. New analysis from Frost ... Market in Europe and ...
(Date:11/21/2014)... , Nov. 20, 2014   Atmel® Corporation ... in microcontroller (MCU) and touch technology solutions, today launched ... sensors with the widest V cc range ... temperature accuracy and faster I 2 C bus communication ... serial EEPROM memory making them ideal for consumer, industrial, ...
(Date:11/18/2014)... Nov. 17, 2014   News ... collaborate to develop The Partners Data Lake, an ... Partners Data Lake will allow researcher and clinicians ... treatment and the lives of patients , ... clinical activities across the Partners system, breaking down ...
Breaking Biology News(10 mins):Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5
... Other important data the European IVF Monitoring group (EIM) ... Technologies (ICMART) on 2007 cycles highlighted were Sweden,s low rate ... and Spain,s 30 % share of egg donations in Europe. ... cycles for the first time. Until today, egg freezing is ...
... University of California, Berkeley, and the University of Maryland ... Nevada hot spring that happily eats plant material ... water. In fact, the microbe,s cellulose-digesting enzyme, ... 109 degrees Celsius (228 degrees Fahrenheit), significantly above the ...
... After an 88-year-long hiatus North America,s tallest bird, the statuesque ... exhibit at the Bird House at the Smithsonian,s National Zoological ... Springs State Park in Florida and is now on exhibit ... two crane species native to the United States. There are ...
Cached Biology News:For the first time, the European IVF Monitoring Group reports on cycles using frozen eggs 2For the first time, the European IVF Monitoring Group reports on cycles using frozen eggs 3Hot springs microbe yields record-breaking, heat-tolerant enzyme 2Hot springs microbe yields record-breaking, heat-tolerant enzyme 3National Zoo Welcomes Whooping Crane 2
(Date:12/19/2014)...  Roche (SIX: RO, ROG; OTCQX: RHHBY) announced ... a privately held company based in ... a big data platform for centralized management and ... proprietary on-market Genomic Management Solution, Bina-GMS 1 , ... fast and scalable analyses to maximize the value ...
(Date:12/19/2014)... FL (PRWEB) December 18, 2014 ... the nation’s leading specialty pharmacies, has an expanded ... as clinical pharmacy consultants for prescriber offices in ... expertise. , “We have a variety of ... For example, those specializing in hepatitis C help ...
(Date:12/19/2014)... Reports from CDC show approximately ... one or more chronic health conditions - including cardiovascular ... some of these diseases, but may not eliminate the ... While implanted nerve stimulation devices today offer relief, they ... can induce side effects. , To eliminate the ...
(Date:12/19/2014)... (PRWEB) December 18, 2014 With only ... time special on Sartorius Biohit products . The ... mLINE pipettes, Picus Electronic Pipette Trade-in Program, and free ... and Safety officers around the world. They are ideal ... Other features include:, ,     Full volume range ...
Breaking Biology Technology:Roche acquires Bina Technologies and enters the genomic informatics market 2Roche acquires Bina Technologies and enters the genomic informatics market 3BioPlus Specialty Pharmacy Expands ‘Regional Pharmaceutical Care Liaison’ Team 2BioPlus Specialty Pharmacy Expands ‘Regional Pharmaceutical Care Liaison’ Team 3Draper Wins GSK Funding for Smaller, Smarter Implantable Devices 2Major Pipette Distributor Pipette.com Announces Sartorius Year End Specials 2
... Decision Resources, one of the world,s leading research and ... through 2019, the combined sales of seven new therapies ... $5 billion in the United States, France, Germany, Italy, ... for the indication, surveyed experts are particularly enthusiastic about ...
... correctly predicted the 2009 H1N1 (Swine Flu) outbreak a ... The same rise in Replikin Count of these genomic ... virus, may similarly warn of the coming of severe ... two separate Replikins* genes, one for infectivity and one ...
... 27 /PRNewswire-Asia/ -- Sinovac Biotech Ltd. (Nasdaq: ... China, announced today that Mr. Jacob Ho, Acting Chief ... Ms. Helen Yang, Investor Relations Manager, are scheduled to ... in early November. Goldman Sachs China ...
Cached Biology Technology:Combined Sales of Seven Emerging Therapies for Breast Cancer, Including Drugs From Sanofi-Aventis and AstraZeneca, Will Total Nearly $5 Billion by 2019 2New Finding of Rise in H5N1 Virus (Avian Flu) Replikin Count 2Sinovac Participates in Two Investor Conferences in November 2
Human Presenilin-2 NTF Affinity Purified Polyclonal Ab...
2'-Fluorine-CTP (2'-F-CTP) is readily incorporated into transcripts by T7 and SP6 R&DNA™ Polymerase and is available separately....
Human Glypican 2 Biotinylated Affinity Purified PAb...
Tachykinin (H-2)...
Biology Products: