Navigation Links
New clue to lupus: Failed autoimmune suppression mechanism
Date:2/3/2011

Bar Harbor, Maine Researchers at Dana-Farber Cancer Institute in Cambridge, Mass., in collaboration with Jackson Laboratory scientists, have identified a regulatory defect that drives lupus.

Correcting the defect "may represent an effective therapeutic approach to systemic lupus erythematosus-like autoimmune disease," the researchers state in their research paper, published in the Proceedings of the National Academy of Sciences. The research team was led by Harvey Cantor, M.D., chair of the department of cancer immunology and AIDS at Dana-Farber, in collaboration with the laboratory of Jackson Professor Derry Roopenian, Ph.D.

Autoimmune diseases develop when the immune system, which is supposed to identify and vanquish potentially dangerous infectious agents, instead attacks the individual's own body. Most autoimmune diseases strike specific organs, such as the pancreas in type 1 diabetes. Lupus, however, is a systemic disease in which abnormal antibodies are produced throughout the body, inflaming a variety of tissues and organs, including the skin, heart, lungs, kidneys and brain.

Follicular T helper (TFH) cells fuel B cells to produce antibodies, which can be useful in fighting infections. But in lupus, TFH fuel B cells that produce dangerous antibodies that attack normal tissues (autoantibodies). CD8+ T cells ("killer T cells"), on the other hand, normally attack and destroy only infected cells. Cantor and colleagues discovered that a small, but critically important, population of CD8+ T cells (less than 5 percent), plays a specialized role in protecting from lupus. These so-called CD8+ T regulatory, or Treg, cells are specially equipped to destoy TFH cells, and by doing so, prevent lupus from developing.

Using a mouse model for systemic lupus erythematosus in humans that was originally discovered at 30 years ago by Edwin Murphy at The Jackson Laboratory, the Dana-Farber researchers, working with Roopenian's laboratory, found defects in CD8+ Treg activity.

The new paper, Roopenian explains, is the first to demonstrate the potential breakdown of this suppression mechanism in lupus. "Overcoming this defect," he says, "offers a potential approach prevent lupus."


'/>"/>

Contact: Joyce Peterson
joyce.peterson@jax.org
207-288-6058
Jackson Laboratory
Source:Eurekalert

Related biology news :

1. Why King Kong failed to impress
2. JAX publishes online tool for exploring autoimmune disease gene networks
3. Vitamin D may exacerbate autoimmune disease
4. Unexpected finding opens up new way to stop autoimmune diseases and transplant rejection
5. Regulatory molecule for tumor formation or suppression identified by Singapore, US researchers
6. Scripps research team sheds light on immune system suppression
7. Scripps Research scientists reveal key mechanism governing nicotine addiction
8. Defense mechanism against bacteria and fungi deciphered
9. Mechanisms of juvenile hormone action in insects could help fine tune pesticides
10. Carnegie Mellon researchers discover mechanism for signaling receptor recycling
11. BUSM researchers uncover cellular mechanism responsible for chronic inflammation, Type 2 diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2017)... -- Janice Kephart , former 9/11 Commission ... LLP (IdSP) , today issues the following statement: ... 6, 2017 Executive Order: Protecting the Nation ... instilled with greater confidence, enabling the reactivation of ... are suspended by until at least July 2017). ...
(Date:4/18/2017)... -- Socionext Inc., a global expert in SoC-based imaging and computing solutions, ... which features the company,s hybrid codec technology. A demonstration utilizing TeraFaces ... will be showcased during the upcoming Medtec Japan at Tokyo Big ... Las Vegas Convention Center April 24-27. ... Click here for an image of ...
(Date:4/13/2017)... 2017 UBM,s Advanced Design and Manufacturing event ... emerging and evolving technology through its 3D Printing and ... alongside the expo portion of the event and feature ... focused on trending topics within 3D printing and smart ... event will take place June 13-15, 2017 at the Jacob ...
Breaking Biology News(10 mins):
(Date:6/22/2017)... ... June 22, 2017 , ... RURO, Inc., ... Limfinity® version 6.5, a content-packed update to the Limfinity® framework. , LimitLIS® and ... and more diverse base of customers among labs and other businesses. Limfinity® 6.5 ...
(Date:6/20/2017)... NEWTOWN SQUARE, Pa. , June 20, 2017 /PRNewswire/ ... technology, is pleased to announce the issuance of a ... treating gout or hyperuricemia by the U.S. Patent and ... Biotech Inc., a winner of the Buzz of Bio ... , is akin to developing non-drug approaches to ...
(Date:6/19/2017)... ... June 19, 2017 , ... EDETEK, Inc., a clinical technology ... is launching two new additions of its award-winning cloud-based platform CONFORM™: Information Hub ... DIA 2017 Annual Meeting in Chicago, IL, June 19-22, 2017. , “Modern clinical ...
(Date:6/16/2017)... ... June 16, 2017 , ... CTNext , Connecticut’s go-to resource for ... at The LOFT at Chelsea Piers in Stamford. , Nine finalists, all of whom ... judges for an opportunity to secure $10,000 awards to help support business growth. The ...
Breaking Biology Technology: