Navigation Links
New clue to lupus: Failed autoimmune suppression mechanism
Date:2/3/2011

Bar Harbor, Maine Researchers at Dana-Farber Cancer Institute in Cambridge, Mass., in collaboration with Jackson Laboratory scientists, have identified a regulatory defect that drives lupus.

Correcting the defect "may represent an effective therapeutic approach to systemic lupus erythematosus-like autoimmune disease," the researchers state in their research paper, published in the Proceedings of the National Academy of Sciences. The research team was led by Harvey Cantor, M.D., chair of the department of cancer immunology and AIDS at Dana-Farber, in collaboration with the laboratory of Jackson Professor Derry Roopenian, Ph.D.

Autoimmune diseases develop when the immune system, which is supposed to identify and vanquish potentially dangerous infectious agents, instead attacks the individual's own body. Most autoimmune diseases strike specific organs, such as the pancreas in type 1 diabetes. Lupus, however, is a systemic disease in which abnormal antibodies are produced throughout the body, inflaming a variety of tissues and organs, including the skin, heart, lungs, kidneys and brain.

Follicular T helper (TFH) cells fuel B cells to produce antibodies, which can be useful in fighting infections. But in lupus, TFH fuel B cells that produce dangerous antibodies that attack normal tissues (autoantibodies). CD8+ T cells ("killer T cells"), on the other hand, normally attack and destroy only infected cells. Cantor and colleagues discovered that a small, but critically important, population of CD8+ T cells (less than 5 percent), plays a specialized role in protecting from lupus. These so-called CD8+ T regulatory, or Treg, cells are specially equipped to destoy TFH cells, and by doing so, prevent lupus from developing.

Using a mouse model for systemic lupus erythematosus in humans that was originally discovered at 30 years ago by Edwin Murphy at The Jackson Laboratory, the Dana-Farber researchers, working with Roopenian's
'/>"/>

Contact: Joyce Peterson
joyce.peterson@jax.org
207-288-6058
Jackson Laboratory
Source:Eurekalert

Page: 1 2

Related biology news :

1. Why King Kong failed to impress
2. JAX publishes online tool for exploring autoimmune disease gene networks
3. Vitamin D may exacerbate autoimmune disease
4. Unexpected finding opens up new way to stop autoimmune diseases and transplant rejection
5. Regulatory molecule for tumor formation or suppression identified by Singapore, US researchers
6. Scripps research team sheds light on immune system suppression
7. Scripps Research scientists reveal key mechanism governing nicotine addiction
8. Defense mechanism against bacteria and fungi deciphered
9. Mechanisms of juvenile hormone action in insects could help fine tune pesticides
10. Carnegie Mellon researchers discover mechanism for signaling receptor recycling
11. BUSM researchers uncover cellular mechanism responsible for chronic inflammation, Type 2 diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/2/2015)... April 2, 2015 Fingerprint Cards ... sensor FPC1025 from the distributor World Peace Industrial Group ... Q2 2015 although the major part of the shipments ... be used by smartphone manufacturers in China ... included in the communicated revenue guidance of + 1 000 ...
(Date:4/1/2015)... Medisafe ™, the leading global medication management platform with ... Android smartphones and tablets, announces today that ... allow patients to track and correlate their adherence directly ... be able to visualize in real-time how taking medication ... glucose levels and blood pressure. "Patients need ...
(Date:3/31/2015)... NEW YORK , March 31, 2015   ... announced the launch of the Post-Surgical Pain Management TRACKER, ... data products tracking usage trends in the medical device ... monthly access to data including treatment volumes, market share, ... manage the pain associated with joint surgery. ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2Medisafe Announces Launch of Biometric Integration, Enabling Patients to Stay Adherent to Their Meds and See Tangible Health Results 2Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3
... Northeastern University professor may have altered the way we look ... of a human protein called APOBEC3G (A3G). In ... Williams and his graduate student Kathy Chaurasiya, along with several ... HIV infection. APOBEC3G , It is ...
... This news release is available in ... in foods such as meat, eggs, and dairy products, was until ... Researchers at the University of Montreal and its affiliated CHU Sainte-Justine ... development. This is not the case for other organs. "The cells ...
... fragments, researchers say they have achieved enough coherence of ... their potential for precise quantum sensors in a material ... detectors - which can be inserted into living cells ... reactions within single cells to signalling in neural networks ...
Cached Biology News:Bonding together to fight HIV 2Bonding together to fight HIV 3Meat, egg and dairy nutrient essential for brain development 2Meat, egg and dairy nutrient essential for brain development 3Diamond 'flaws' pave way for nanoscale MRI 2
(Date:5/5/2015)... , May 5, 2015 Roka Bioscience, Inc. ... providing advanced testing solutions for the detection of foodborne pathogens, ... at the Bank of America Merrill Lynch 2015 Health Care ... be held at Encore at the Wynn, Las ... of the presentation will be available through the investor relations ...
(Date:5/5/2015)... , May 5, 2015 Psyche Systems Corporation ... which offers a first-of-its-kind platform that helps labs comply ... lab results, transforms the way patients engage with these ... Luminate Health provides a HIPAA-compliant digital platform that ... manage, and understand their lab results, and uniquely connects ...
(Date:5/5/2015)... 5, 2015 ImmunoCellular Therapeutics, Ltd. ("ImmunoCellular") ... , President and Chief Executive Officer, will present ... DATE:  Thursday, May 7, 2015     TIME:  11:30 am ... > click the red "register/ watch presentations" button ... online event where investors are invited to ask ...
(Date:5/5/2015)... , May 05, 2015 Research and ... the addition of the "Clinical Laboratory, Molecular ... Forecasts 2015 to 2019 - Europe Version" ... developments especially in the area of molecular diagnostics ... growing and evolving world market that is moving ...
Breaking Biology Technology:Psyche Systems Corporation Forms Strategic Alliance with Luminate Health to Provide First-of-its-kind Patient Access Solution 2Psyche Systems Corporation Forms Strategic Alliance with Luminate Health to Provide First-of-its-kind Patient Access Solution 3ImmunoCellular Therapeutics to Webcast Live at VirtualInvestorConferences.com on May 7 2European Clinical Laboratory, Molecular Diagnostics and Genomic Testing Services Market 2015-2019 2
... today that it has entered into a strategic ... SHQ), to jointly develop AT-1001,Alba,s lead inhibitor of ... receive rights to commercialize all forms of,AT-1001 outside ... retain all rights,to commercialize AT-1001 in the United ...
... Isis,Pharmaceuticals, Inc. (Nasdaq: ISIS ) today announced ... Parshall, J.D. to Chief Operating Officer,effective immediately. Ms. ... is a Director of the Company., "This ... Lynne,s responsibilities at Isis," commented Stanley Crooke, M.D.,Ph.D., ...
... Dec. 14 FMC Corporation (NYSE:,FMC) and ... the companies,have entered into a worldwide license ... novel capsule technology developed by FMC. The,alginate-based ... product life-cycle management of Pronova BioPharma,s products ...
Cached Biology Technology:Alba Therapeutics Corporation and Shire plc Enter Into $325 Million ex-US, ex-Japan Licensing Agreement to Develop and Commercialize AT-1001 2Alba Therapeutics Corporation and Shire plc Enter Into $325 Million ex-US, ex-Japan Licensing Agreement to Develop and Commercialize AT-1001 3Isis Announces Appointment of B. Lynne Parshall as Chief Operating Officer 2Isis Announces Appointment of B. Lynne Parshall as Chief Operating Officer 3FMC Corporation and Pronova BioPharma Announce Agreement To Develop New Alginate-Based Capsule Products 2FMC Corporation and Pronova BioPharma Announce Agreement To Develop New Alginate-Based Capsule Products 3FMC Corporation and Pronova BioPharma Announce Agreement To Develop New Alginate-Based Capsule Products 4
... liquid handling system from Molecular Devices provides ... one instrument. The system handles a variety ... washing96-, 384- and 1536-welland is the first ... has been optimized to dispense from four ...
... Plate consists of an anodized aluminum body ... Fluorescent Compounds embedded in polymerized matrix. It ... FLx800 and Synergy Multi-Detection Readers. This multi-functional ... while reducing the need for tedious wet ...
... the SMZ line is a Greenough stereomicroscope designed ... It is available with a choice of a ... compact base (N2GG). This microscope can be easily ... all at the same time giving you ultimate ...
... for siRNA applications, contains magnetic nanoparticles (MagTag) ... acid of interest. Exploiting magnetic force the ... drawn towards and delivered into the target ... can be used for adherent cells; for ...
Biology Products: